Theoretical investigation on FRET strategy of ratio metric fluorescent probe sensing hydrogen sulfide

The level of hydrogen sulfide (H2S) in human body is related to many diseases, such as Alzheimer's disease, Down syndrome, etc. Therefore, the detection of H2S level in biological systems is very important and has attracted great attention from scientific and clinical researchers. Understanding the design and working mech-anism of fluorescent probes for H2S level detection is important for building new highly efficient fluorescent probe. The mechanisms of a recently reported efficient small molecule fluorescent probe based on the Fluores-cence Resonance Energy Transfer (FRET) were investigated thoroughly in this work. The theoretical results would provide the insights for designing new efficient and multi-functional fluorescent probe applicable in the biological systems.

Automated summary

The level of hydrogen sulfide (H2S) in the human body is associated with various diseases. Therefore, the detection of H2S level in biological systems is important and has attracted attention from researchers. This study thoroughly investigated the mechanisms of a highly efficient fluorescent probe based on the Fluorescence Resonance Energy Transfer (FRET), providing insights for designing new probes applicable in biological systems.