Coumarin-cyanine hybrid: A ratiometric fluorescent probe for accurate detection of peroxynitrite in mitochondria

Article Spectroscopy

The coumarin-pyrazole dye for detection of hydrogen sulfide in cells

Guang-Jin Shi et al.

Summary: In this study, a novel fluorescent probe was designed for specific detection of H2S, showing wide applicability and excellent detection properties.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2023)

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Article Spectroscopy

Efficient deep blue emission by 4-styrylbenzonitrile derivatives in solid state: Synthesis, aggregation induced emission characteristics and crystal structures

Ying Fang et al.

Summary: Organic fluorescent molecules with pi-conjugated system have significant importance in applications such as bioimaging and optoelectronics. This study successfully synthesized highly planar 4-styrylbenzonitrile derivatives and discovered their strong luminescent properties in the solid state.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Multidisciplinary

Chiral Thermally Activated Delayed Fluorescence-Active Macrocycles Displaying Efficient Circularly Polarized Electroluminescence

Wen-Long Zhao et al.

Summary: An efficient strategy for constructing chiral macrocycles with both TADF and CPEL properties was developed. The macrocycles exhibited aggregation-induced emission and high photoluminescence quantum yields, and were suitable for the preparation of high-performance circularly polarized organic light-emitting diodes.

CCS CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Pagoda[5]arene with Large and Rigid Cavity for the Formation of 1:2 Host-Guest Complexes and Acid/Base-Responsive Crystalline Vapochromic Properties

Xiao-Ni Han et al.

Summary: Pagoda[5]arene (P5), composed of five 2,6-dimethoxylanthracene (2,6-DMA) subunits, was synthesized conveniently and showed a symmetrical pentagonal structure with a large and deep electron-rich cavity. It demonstrated stable 1:2 host-guest complexes with various aryl-pyridinium, bipyridinium, and stilbazolium salts in solution. The complexes formed by P5 and protonated pyridinium or bipyridinium salts exhibited acid/base-responsive color changes and remarkable crystalline vapochromic properties.

CCS CHEMISTRY (2022)

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Article Chemistry, Analytical

A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity

Li Ruan et al.

Summary: Lysosomes play a crucial role in physiological and pathological processes. To monitor their movement and action in real-time, a series of lysosome-targeting fluorescent probes were designed, with one particular probe demonstrating excellent targeting ability and photostability.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Physical

Red-emitting Fluorescent Probe for Visualizing Endogenous Peroxynitrite in Live Cells and Inflamed Mouse Model

Huihui Su et al.

Summary: Inflammation is a crucial immune protective response in living organisms, and the red-emitting fluorescent probe RFAc can monitor and selectively determine ONOO-, which is important for research on inflammatory-related diseases.

JOURNAL OF MOLECULAR STRUCTURE (2022)

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Article Chemistry, Analytical

A near-infrared fluorescent probe for ratiometric imaging peroxynitrite in Parkinson's disease modelY

Hao Kang et al.

Summary: Parkinson's disease is a common neurodegenerative disease that causes great pain and economic burden. Peroxynitrite (ONOO-) plays a significant role in the development of Parkinson's disease, but effective detection methods are currently lacking. This study design a highly sensitive and selective near-infrared ratiometric fluorescent probe to track ONOO- and successfully observe its changes in a Parkinson's disease model.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Physical

A hemicyanine-based near-infrared fluorescent probe for visualizing biothiols fluctuations induced by Ag+ in mitochondria

Yang Wang et al.

Summary: A novel near-infrared fluorescent probe CySNC has been developed to monitor fluctuations of biothiols in response to oxidative stress caused by heavy metal ion poisoning. The probe showed excellent fluorescence response to Cys/Hcy/GSH under physiological conditions and had short response times. It was also successful in visualizing biothiol fluctuations induced by Ag+ in mitochondria.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2022)

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Article Biochemical Research Methods

Enhancing probe's sensitivity for peroxynitrite through alkoxy modification of dicyanovinylchromene

Hui Yu et al.

Summary: In this study, a novel fluorescent probe P-ONOO- was synthesized for the detection of ONOO- based on intramolecular charge transfer. The probe showed fast response, high sensitivity, and good selectivity towards ONOO-, and it was capable of imaging endogenous and exogenous ONOO- in cells.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Applied

Cysteine recognition by a benzothiazole-derived fluorescent probe with AIE plus ESIPT characteristics

Yongxin Pan et al.

Summary: In this study, a series of fluorescent dyes based on 2-(2'-hydroxyphenyl)benzothiazole derivatives were designed and synthesized, which exhibited long-wavelength emission and a larger Stokes shift due to their structural characteristics of AIE + ESIPT. A fluorescent probe, HBTN-Y, was prepared based on the fluorescent dye HBTN and showed high selectivity towards cysteine, with OFF-ON fluorescence response, a large Stokes shift, and long-wavelength emission in a specific solution. The probe demonstrated good anti-interference ability, low detection limit, and applicability for live cell imaging.

DYES AND PIGMENTS (2022)

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Article Chemistry, Analytical

A sequential dual-key-dual-lock fluorescent probe for detection of SO2 and H2O2 in cells and mice

Ying Fang et al.

Summary: This study designed and synthesized a novel fluorescent probe BN-DUAL for sequential detection and identification of SO2 and H2O2 using a dual-key-dual-lock strategy. The probe improved the selectivity and accuracy of detecting SO2 and H2O2 in cells and in vivo, and the signal changes of the two channels made the detection clearer and more visualized. The probe's effectiveness was demonstrated by imaging exogenous and endogenous SO2/H2O2 in cells and mice.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Applied

Artificial light-harvesting systems based on self-assembled fluorescent palladium(II)-metallacycle in aqueous solution

Yi-Meng Duan et al.

Summary: In this study, a novel artificial light harvesting system was designed and constructed using a fluorescent tetragonal Pd(II)-metallacycle as a platform. The system achieved high energy transfer efficiency through the coordination of suitable acceptors.

DYES AND PIGMENTS (2022)

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Article Chemistry, Applied

Imidazobenzothiadiazole: A new multifunction dyes for mechanochromic luminescence, acid responsing and mitochondrial staining

Guang-Jin Shi et al.

Summary: In this study, three imidazobenzothiadiazole (ImBTD) fluorescent dyes were successfully synthesized and characterized. It was found that the introduction of imidazole groups at specific positions enhanced fluorescence and allowed for acid fluorescence response. Modification of different aromatic groups at other positions also resulted in tunable mechanochromic luminescence. These dyes also showed comparable mitochondrial staining ability to commercially available positively charged dyes.

DYES AND PIGMENTS (2022)

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Article Spectroscopy

A hemicyanine-based near-infrared fluorescent probe for vapor-phase hydrazine detection and bioimaging in a complete aqueous media

Yang Wang et al.

Summary: This study reports a novel near-infrared fluorescent probe CyOE, which exhibits high selectivity, sensitivity, and good water solubility for rapid detection of hydrazine in aqueous solutions and real water samples.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Multidisciplinary

Two-photon fluorescence imaging of the cerebral peroxynitrite stress in Alzheimer's disease

Xilei Xie et al.

Summary: In this study, a novel fluorescent probe was designed and synthesized, allowing the visualization of the crucial role of peroxynitrite in Alzheimer's disease through in vivo experiments in mice.

CHEMICAL COMMUNICATIONS (2022)

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Article Chemistry, Analytical

A two-photon fluorescent probe for visualizing endoplasmic reticulum peroxynitrite in Parkinson's disease models

Ming Yan et al.

Summary: Endoplasmic reticulum (ER) stress is involved in diseases like Parkinson's disease, with peroxynitrite being a pivotal factor. A two-photon fluorescence probe, ER-PN, was designed and synthesized for visualizing ER peroxynitrite in PD models. The probe showed rapid and highly selective response to peroxynitrite in vitro, making it a promising tool for imaging peroxynitrite in ER stress-related diseases.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Highly Sensitive Near-Infrared Imaging of Peroxynitrite Fluxes in Inflammation Progress

Zhao Wang et al.

Summary: The article presents a highly sensitive NIR fluorescence probe DDAO-PN for in vivo detection of ONOO- in inflammation. The probe demonstrates rapid response and high sensitivity in detecting ONOO-, which has the potential to advance research on inflammation-related diseases.

ANALYTICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Interplay between reactive oxygen and nitrogen species in living organisms

Volodymyr Lushchak et al.

Summary: In living organisms, most oxygen is reduced to water through four-electron reduction, but a small percentage is reduced through one-electron mechanisms to produce reactive oxygen and nitrogen species. These species interact with various components of living organisms, leading to diverse effects on biological systems.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Article Chemistry, Analytical

An SMVT-targeting and peroxynitrite-activating fluorescent probe for head and neck cancer imaging and peroxynitrite detection

Yue Wu et al.

Summary: The study developed a novel fluorescent probe RB-PN for precise detection of HNSCC, which can be applied in tumor visualization and cytokine therapy. The probe with a dual-targeting strategy has rapid response, high specificity, and selectivity.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Spectroscopy

A morpholino hydrazone-based lysosome-targeting fluorescent probe with fast response and high sensitivity for imaging peroxynitrite in living cells

Biao Gu et al.

Summary: A novel lysosome-targetable fluorescent probe BMP was designed and synthesized in this study for selective detection of ONOO- in living systems. The probe showed fast response, high sensitivity, and excellent selectivity towards ONOO- with the capability of imaging ONOO- in lysosomes.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Article Spectroscopy

A mitochondria-targeted fluorescent probe for real-time imaging SO2/H2O2

Yang Wang et al.

Summary: The study introduced a long-wavelength fluorescent probe with high selectivity and sensitivity to reversibly monitor sulfur dioxide and hydrogen peroxide in living cells. The probe could accumulate in mitochondria for real-time imaging of SO2/H2O2, making it an ideal tool for monitoring the redox cycle state in living cells.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Article Spectroscopy

A coumarin-based portable fluorescent probe for rapid turn-on detection of amine vapors

Yuanyuan Meng et al.

Summary: A new fluorescent sensor BZCO has been developed for the detection of volatile amine vapors. This paper-based sensor exhibits high sensitivity and good selectivity, making it suitable for various applications such as food processing and fluorescent security ink.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Article Chemistry, Analytical

A chromene based fluorescence probe: Accurate detection of peroxynitrite in mitochondria, not elsewhere

Ying Fang et al.

Summary: The novel fluorescent probe BC-PN-2 is used for detecting ONOO- with short response time, high sensitivity, and excellent selectivity. Fluorescence imaging shows high membrane permeability and mitochondrial targeting effect of the probe.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Spectroscopy

A novel borate fluorescent probe for rapid selective intracellular peroxynitrite imaging

Minmin Wang et al.

Summary: A new fluorescent probe based on benzyl borate group was designed to detect peroxynitrite with high selectivity and sensitivity, showing high fluorescence response in a wide pH range. The probe also exhibited good permeability, successfully monitoring the content of peroxynitrite in cancer cells and normal cells.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

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Correction Biochemistry & Molecular Biology

Modification of lactoferrin by peroxynitrite reduces its antibacterial activity an changes protein structure (vol 88, pg 166, 2020)

Amani Y. Alhalwani et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2021)

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Article Chemistry, Multidisciplinary

Sensitive and specific detection of peroxynitrite and in vivo imaging of inflammation by a simple AIE bioprobe

Huilin Xie et al.

Summary: A luminogenic bioprobe TPE-DMAB has been developed for the simple and specific detection of peroxynitrite, showing aggregation-induced emission characteristics and high sensitivity. Encapsulated nanoparticles of TPE-DMAB have been successfully used to detect endogenous ONOO- in macrophage cells and visualize inflammation sites in mice, demonstrating its great potential for biological applications.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Article Chemistry, Analytical

A new mitochondria-targeting fluorescent probe for ratiometric detection of H2O2 in live cells

Chengcheng Wang et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Biochemical Research Methods

A diazabenzoperylene derivative as ratiometric fluorescent probe for cysteine with super large Stokes shift

Shuo Wang et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Engineering, Chemical

Facile and Highly Selective Ratiometric Fluorescence Probe Based on Benzo[5]helicene for the Detection of Hypochlorous Acid

Yi-Meng Duan et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2020)

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Article Chemistry, Analytical

Cancer cell recognition by a Cys-reactive turn-on significant enhanced fluorescent emission targeting biotin receptors

Xueying Pei et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Article Spectroscopy

Tetrahydro[5]helicene fused nitrobenzoxadiazole as a fluorescence probe for hydrogen sulfide, cysteine/homocysteine and glutathione

Xing-Hao Gu et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2020)

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Article Chemistry, Analytical

Acryl-modified diazabenzo[ghi]perylene for fast discrimination of Cys from GSH and Hcy with high quantum yield

Qi Zhang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2020)

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Review Chemistry, Multidisciplinary

Synthetic ratiometric fluorescent probes for detection of ions

Sang-Hyun Park et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Review Chemistry, Multidisciplinary

Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins

Paolo Di Mascio et al.

CHEMICAL REVIEWS (2019)

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Article Spectroscopy

A coumarin-based fluorescent probe for ratiometric detection of hydrazine and its application in living cells

Peng Qu et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2019)

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Article Chemistry, Applied

A hydrazone-based turn-on fluorescent probe for peroxynitrite detection and live-cell imaging

Sudeok Kim et al.

DYES AND PIGMENTS (2019)

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Article Chemistry, Analytical

Construction of a ratiometric probe with dual quenching mechanisms for selectively imaging intracellular sulfur dioxide overcoming the interference from cysteine

Qilong Zhang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

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Article Food Science & Technology

Oxidation of myofibrillar proteins induced by peroxyl radicals: Role of oxidizable amino acids

E. Dorta et al.

FOOD RESEARCH INTERNATIONAL (2019)

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Article Chemistry, Multidisciplinary

A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite

Luling Wu et al.

CHEMISTRYOPEN (2019)

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Article Chemistry, Multidisciplinary

Near-infrared turn-on fluorescent probe for discriminative detection of Cys and application in in vivo imaging

Shaolong Qi et al.

RSC ADVANCES (2019)

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Article Chemistry, Analytical

A colorimetric and ratiometric fluorescent probe for highly selective detection of glutathione in the mitochondria of living cells

Sujie Qi et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Article Chemistry, Analytical

A rapid responsive colorimetric and near-infrared fluorescent turn-on probe for imaging exogenous and endogenous peroxynitrite in living cells

Dandan Liu et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

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Article Chemistry, Organic

A boronate-based ratiometric fluorescent probe for fast selective detection of peroxynitrite

Qi Li et al.

TETRAHEDRON LETTERS (2018)

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Review Biochemistry & Molecular Biology

Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration

Silvina Bartesaghi et al.

REDOX BIOLOGY (2018)

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Article Chemistry, Analytical

Real-Time Monitoring of Endogenous Cysteine Levels In Vivo by near-Infrared Turn-on Fluorescent Probe with Large Stokes Shift

Yu Qi et al.

ANALYTICAL CHEMISTRY (2018)

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Article Chemistry, Multidisciplinary

Imaging of formaldehyde in plants with a ratiometric fluorescent probe

Zhen Li et al.

CHEMICAL SCIENCE (2017)

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Review Neurosciences

Cellular mechanisms of peroxynitrite-induced neuronal death

Kristina Ramdial et al.

BRAIN RESEARCH BULLETIN (2017)

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Article Chemistry, Multidisciplinary

Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo

Fabiao Yu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

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Article Chemistry, Multidisciplinary

A Near-IR Reversible Fluorescent Probe Modulated by Selenium for Monitoring Peroxynitrite and Imaging in Living Cells

Fabiao Yu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Biochemistry & Molecular Biology

Chemistry and biology of reactive oxygen species in signaling or stress responses

Bryan C. Dickinson et al.

NATURE CHEMICAL BIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Ultraviolet B Light-induced Nitric Oxide/Peroxynitrite Imbalance in Keratinocytes-Implications for Apoptosis and Necrosis

Shiyong Wu et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2010)

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Article Cell Biology

Preferential recognition of peroxynitrite modified human DNA by circulating autoantibodies in cancer patients

Safia Habib et al.

CELLULAR IMMUNOLOGY (2009)

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Review Pharmacology & Pharmacy

Metalloporphyrins as a therapeutic drug class against peroxynitrite in cardiovascular diseases involving ischemic reperfusion injury

Simon W. Rabkin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Article Neurosciences

Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes

JF Li et al.

NEUROSCIENCE LETTERS (2003)

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Article Pharmacology & Pharmacy

Activation of microsomal glutathione S-transferase by peroxynitrite

YB Ji et al.

MOLECULAR PHARMACOLOGY (2003)

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Coumarin-cyanine hybrid: A ratiometric fluorescent probe for accurate detection of peroxynitrite in mitochondria

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