4.8 Article

Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual-Signal Transform-Based Selenium Antioxidant

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

Kruppel-like factor 2 contributes to blood-spinal cord barrier integrity and functional recovery from spinal cord injury by augmenting autophagic flux

Zili He et al.

Summary: Increasing evidence suggests that defects in autophagy and autophagy-lysosomal pathway (ALP) may contribute to endothelial barrier disruption following acute traumatic spinal cord injury (SCI). This study investigates whether Kruppel-like factor 2 (KLF2) coordinates ALP in endothelial cells in SCI. The results demonstrate that KLF2 is a key contributor to SCI-mediated ALP dysfunction and blood-spinal cord barrier (BSCB) disruption, and could be a promising pharmacological target for SCI management and treatment.

THERANOSTICS (2023)

Article Chemistry, Multidisciplinary

A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction

Quan Sun et al.

Summary: Myocardial infarction (MI) is a leading cause of death globally. Reactive oxygen species (ROS) play a crucial role in the progression of MI. The development of self-sustaining selenium-embedded nanoparticles (SSSe NPs) provides an innovative antioxidant strategy for MI treatment.

ADVANCED SCIENCE (2023)

Article Biotechnology & Applied Microbiology

Neuroprotective activity of a virus-safe nanofiltered human platelet lysate depleted of extracellular vesicles in Parkinson's disease and traumatic brain injury models

Liling Delila et al.

Summary: This study evaluated the virus removal properties of a nanofiltration process on human platelet lysates (HPL) and found that it effectively reduced viral and procoagulant risks while preserving the neuroprotective and anti-inflammatory properties of HPL.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

Article Medicine, Research & Experimental

Transcriptomic analysis of the innate immune response to in vitro transfection of plasmid DNA

Eric Warga et al.

Summary: This study used mRNA sequencing to identify genes that influence transfection efficiency in different cell types. The highest transfection efficiency was observed in HEK-293T cells with few genes upregulated. PC-3 cells exhibited lower transfection efficiency but upregulated cytokine-stimulated genes. Jurkat and primary T cells had low gene upregulation, possibly due to constitutive expression of antiviral genes.

MOLECULAR THERAPY-NUCLEIC ACIDS (2023)

Review Cell Biology

Neuronal reprogramming in treating spinal cord injury

Xuanyu Chen et al.

Summary: Spinal cord injury is a devastating central nervous system injury with limited treatment options. In vivo neuronal reprogramming, a recently developed technology, shows promise in converting endogenous glial cells into functional neurons for injury repair.

NEURAL REGENERATION RESEARCH (2022)

Article Engineering, Biomedical

Highly bioactive iridium metal-complex alleviates spinal cord injury via ROS scavenging and inflammation reduction

Zhi-Sheng Ji et al.

Summary: A highly bioactive iridium complex was developed to treat spinal cord injuries, with enhanced antioxidative activities and improved therapeutic efficacy. The complex targets SOD1 and upregulates its expression to eliminate excess ROS production, protecting neuron cells from further damage and facilitating repair.

BIOMATERIALS (2022)

Article Chemistry, Multidisciplinary

A Two-In-One Nanoprodrug for Photoacoustic Imaging-Guided Enhanced Sonodynamic Therapy

Songjia Sun et al.

Summary: In this study, a dual-prodrug nano-particle was synthesized for enhanced sonodynamic therapy (SDT) against skin cancers. The nano-particles released ALA and SO2 in tumor cells, leading to increased SDT effect. The results showed that these nano-particles significantly inhibited the growth of melanoma and squamous cell carcinoma in mouse models.
Article Biotechnology & Applied Microbiology

Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment

Siyuan Rao et al.

Summary: In this study, TSIIA@SeNPs-APS, a nanotechnology-based combination of TCM active ingredients, showed promise in the antioxidant therapy of spinal cord injuries. It improved the bioavailability of Huangqi and Danshen and had therapeutic effects by promoting cell survival and alleviating oxidative stress-induced cell damage.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Multidisciplinary Sciences

NIR-II fluorescence visualization of ultrasound-induced blood-brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles

Simin Liang et al.

Summary: In this study, microbubbles (MBs) doped with indocyanine green (ICG) were used to visualize the blood-brain barrier (BBB) opening induced by focused ultrasound (FUS) and enhance photothermal therapy (PTT) against glioblastoma (GBM). MBs-ICG exhibited bright fluorescence in the second near-infrared window (NIR-II), ultrasound contrast, and ultrasound-induced size transformation properties. By combining MBs-ICG with FUS, the BBB opening process could be visualized in real time with a high signal-to-background ratio.

SCIENCE BULLETIN (2022)

Review Cell & Tissue Engineering

Progression in translational research on spinal cord injury based on microenvironment imbalance

Baoyou Fan et al.

Summary: Spinal cord injury (SCI) causes loss of motor and sensory function, imposing a significant burden on patients, families, and society. Although progress has been made in understanding the pathological mechanism of SCI, translational research on repairing the injured spinal cord has not yielded significant results. This review summarizes the latest research progress on SCI pathology and discusses repair strategies based on microenvironment imbalance.

BONE RESEARCH (2022)

Article Biochemistry & Molecular Biology

Tomographic Imaging and Correlation to Quantify Vascular and Inflammatory Changes in an Experimental Spinal Cord Injury

Kirti Adhikari et al.

Summary: The study utilized IVIS spectrum for monitoring the disease pathology after spinal cord injury, identifying Cat B 680 Fast and Angiosense 750 EX as markers for assessing disease severity post SCI, and suggesting that noninvasive fluorescence optical imaging offers a unique approach in monitoring neuroinflammatory diseases in live animals.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Clinical Neurology

Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury

Tobias Zrzavy et al.

Summary: This study provides a detailed characterization of inflammatory responses and oxidative tissue injury in human traumatic spinal cord injury lesions. It reveals that ongoing inflammatory responses and neurotoxicity could lead to sustained neuronal damage long after the initial trauma, potentially impacting the response to rehabilitation and recovery in patients.
Review Chemistry, Inorganic & Nuclear

Fluorescent probes based on nucleophilic aromatic substitution reactions for reactive sulfur and selenium species: Recent progress, applications, and design strategies

Yuning Liu et al.

Summary: RSS and RSeS play important roles in maintaining physiological balance, and their imbalance is closely related to human diseases. Using fluorescent probes for quantitative analysis may promote the development of personalized diagnosis and treatment.

COORDINATION CHEMISTRY REVIEWS (2021)

Article Clinical Neurology

The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data

Jetan H. Badhiwala et al.

Summary: The study investigated the influence of timing of surgical decompression for acute spinal cord injury on neurological outcomes. The results showed that decompressive surgery within 24 hours of injury leads to improved sensorimotor recovery, with a crucial time window for optimal neurological recovery within the first 24-36 hours post-injury.

LANCET NEUROLOGY (2021)

Article Multidisciplinary Sciences

J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging

Kang Li et al.

Summary: J-aggregation has been shown to be an effective strategy for developing fluorescent imaging agents in the NIR-II spectral region. However, designing suitable J-aggregates remains challenging. This study demonstrates the J-aggregation of a BODIPY dye with NIR-II emission and its application in lymph node imaging for fluorescence-guided surgery.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

A General Approach to Convert Hemicyanine Dyes into Highly Optimized Photoacoustic Scaffolds for Analyte Sensing

Sarah H. Gardner et al.

Summary: The study introduced a new dye scaffold, PA-HD, optimized for PA probe development with enhanced sensitivity and red-shift properties. Computational modeling was used to elucidate the origin of these enhanced properties.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Clinical Neurology

Predicting neurological recovery after traumatic spinal cord injury by time-resolved analysis of monocyte subsets

Raban Arved Heller et al.

Summary: This study aimed to evaluate the correlation between remission after traumatic spinal cord injury and the dynamics of monocyte subsets, lymphocytes' responsive potential, cytokine expression, patterns of trace element concentration, and clinical covariates. Clinical research findings suggest that early dynamics in monocyte subsets can predict recovery from traumatic spinal cord injury.
Review Engineering, Biomedical

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Claudio Ferro et al.

Summary: Selenium is an essential element for human health, incorporated into selenocysteine in the body and used to synthesize selenoproteins. While it has beneficial properties, excessive intake can lead to toxicity. Selenium nanoparticles are a less toxic alternative for delivering drug payloads to specific cells, with potential applications in cancer therapy.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Chemistry, Multidisciplinary

Versatile Fluorescent Probes for Imaging the Superoxide Anion in Living Cells and In Vivo

Haibin Xiao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Chirality-Driven Transportation and Oxidation Prevention by Chiral Selenium Nanoparticles

Yanyu Huang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

A Highly Selective and Sensitive Chemiluminescent Probe for Real-Time Monitoring of Hydrogen Peroxide in Cells and Animals

Sen Ye et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Multidisciplinary Sciences

Size and surface charge characterization of nanoparticles with a salt gradient

Martin K. Rasmussen et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Helmut Sies et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Nanoscience & Nanotechnology

Phytoglycogen Nanoparticle Delivery System for Inorganic Selenium Reduces Cytotoxicity without Impairing Selenium Bioavailability

Tamiru N. Alkie et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Review Materials Science, Biomaterials

Design Strategies and Applications of ROS-Responsive Phenylborate Ester-Based Nanomedicine

Ying Liu et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Review Chemistry, Multidisciplinary

Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

Luling Wu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Article Chemistry, Multidisciplinary

Dynamic-Reversible Photoacoustic Probe for Continuous Ratiometric Sensing and Imaging of Redox Status in Vivo

Judun Zheng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Review Clinical Neurology

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

Gergely David et al.

NATURE REVIEWS NEUROLOGY (2019)

Article Multidisciplinary Sciences

Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine

Rafael Radi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Immunology

A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke

Qianyi Huang et al.

JOURNAL OF NEUROINFLAMMATION (2018)

Article Medicine, General & Internal

Traumatic spinal cord injury

Christopher S. Ahuja et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Chemistry, Multidisciplinary

Selenium-Doped Carbon Quantum Dots for Free-Radical Scavenging

Feng Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Biochemistry & Molecular Biology

Cellular and subcellular oxidative stress parameters following severe spinal cord injury

Nishant P. Visavadiya et al.

REDOX BIOLOGY (2016)

Article Integrative & Complementary Medicine

Neuroprotective Effects of Different Modalities of Acupuncture on Traumatic Spinal Cord Injury in Rats

Song-he Jiang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

Article Biochemistry & Molecular Biology

GSK-3/-mediated phosphorylation of CRMP-2 regulates activity-dependent dendritic growth

Minghui Tan et al.

JOURNAL OF NEUROCHEMISTRY (2013)

Article Neurosciences

ERK2 Contributes to the Control of Social Behaviors in Mice

Yasushi Satoh et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Biochemistry & Molecular Biology

Selenium-induced changes in activities of antioxidant enzymes and content of photosynthetic pigments in Spirulina platensis

Tian-Feng Chen et al.

JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2008)

Review Medicine, General & Internal

Spinal-cord injury

JW McDonald et al.

LANCET (2002)