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Three Strategies in Engineering Nanomedicines for Tumor Microenvironment-Enabled Phototherapy

SMALL (2023)

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Wei Li et al.

Summary: Researchers developed an oxazine-based activatable molecular assembly (PTO-Biotin Nps) that can trigger lysosomal dysfunction-mediated Fenton pathway to induce tumor ferroptosis with excellent spatiotemporal resolution using near-infrared light. The assembly selectively accumulates in lysosomes of tumor cells and exhibits enhanced photothermal activity in the acidic tumor microenvironment. Upon activation, PTO-Biotin Nps induce lysosomal dysfunction, cytosolic acidification, impaired autophagy, and enhanced cellular Fenton reactions to induce ferroptosis, leading to improved antitumor efficacy and reduced systemic side effects.

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Summary: The tripeptide glutathione is synthesized in the cytosol of eukaryotic cells and plays a crucial role in redox and detoxification reactions. Its transport to and from organelles and between organs is essential for its functions, with the liver being central to this process. Glutathione serves as a marker of oxidative states in various diseases, aging, and cell death, and also interacts with enzymes and proteins to regulate cellular functions.

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Article Chemistry, Multidisciplinary

Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor

Rong-Rong Zheng et al.

Summary: Photodynamic therapy (PDT) is a promising antitumor modality that can generate reactive oxygen species (ROS) to induce cell apoptosis and immunogenic cell death (ICD). However, overexpressions of IDO and PD-L1 on tumor cells can inhibit immune activation. In this study, a self-delivery biomedicine was developed to enhance photodynamic immunotherapy by inhibiting IDO and blocking PD1/PDL1.

SMALL (2023)

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Article Engineering, Biomedical

Tumor Cell-Responsive Photodynamic Immunoagent for Immunogenicity-Enhanced Orthotopic and Remote Tumor Therapy

Yingchao Chen et al.

Summary: Combining photodynamic therapy (PDT) with immune checkpoint blockades can enhance immunotherapeutic outcomes in cancer treatment. However, the continuous bioactivity of photosensitizers and immune checkpoint inhibitors can lead to uncontrollable side effects. This study develops an activatable photodynamic immunomodulator to improve selectivity and achieve effective cancer therapy.

ADVANCED HEALTHCARE MATERIALS (2023)

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Review Chemistry, Physical

Multifunctional Nano-Biomaterials for Cancer Therapy via Inducing Enhanced Immunogenic Cell Death

Qian Chen et al.

Summary: Immunotherapy is a promising method to overcome cancer, with immunogenic cell death (ICD) attracting attention for cancer immunotherapy. Nano-biomaterials have unique properties at the nanoscale, providing a prospective approach to overcome obstacles in ICD-mediating immunotherapy.

SMALL METHODS (2023)

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Article Chemistry, Multidisciplinary

Aggregation-Induced-Emission Photosensitizer-Loaded Nano-Superartificial Dendritic Cells with Directly Presenting Tumor Antigens and Reversed Immunosuppression for Photodynamically Boosted Immunotherapy

Zhihong Sun et al.

Summary: The success of tumor immunotherapy highlights the potential of harnessing immune system to fight cancer. Strategies for efficient antigen presentation and improving the immunosuppressive microenvironment remain unresolved. This study developed aggregation-induced-emission (AIE) photosensitizer-loaded nano-superartificial dendritic cells (saDC@Fs-NPs) that could directly stimulate T-cell activation and reverse T-cell exhaustion for cancer immunotherapy. The AIE-active photosensitizers induced immunogenic cell death and enhanced T lymphocyte infiltration, promoting the transformation of cold tumors into hot tumors and boosting immunotherapy efficiency.

ADVANCED MATERIALS (2023)

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Review Medicine, Research & Experimental

Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer

Pengzhu Huang et al.

Summary: Endometrial cancer is a common gynecological cancer that poses a significant threat to women's health. Obesity, as a worldwide phenomenon, increases the risk of endometrial cancer, but the underlying mechanism is not fully understood. This study reviews the metabolic reprogramming of glucose in endometrial cancer, not only from a systemic perspective but also focusing on the tumor cell metabolism. Understanding the metabolic profile and the regulation mechanism associated with glucose metabolism in endometrial cancer may offer novel perspectives for treatment.

JOURNAL OF TRANSLATIONAL MEDICINE (2023)

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Polysaccharide-Based Stimulus-Responsive Nanomedicines for Combination Cancer Immunotherapy

Qiuxia Li et al.

Summary: Cancer immunotherapy, though promising, is limited by nontherapeutic side effects, tumor microenvironment complexity, and low tumor immunogenicity. Combination immunotherapy with other therapies has been proven to be effective, but the challenge lies in delivering the drugs to the tumor site.

SMALL (2023)

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Article Nanoscience & Nanotechnology

Biomimetic, pH-Responsive Nanoplatforms for Cancer Multimodal Imaging and Photothermal Immunotherapy

Li Wan et al.

Summary: Photothermal therapy (PTT) is a noninvasive technique that uses light to generate heat for tumor thermal ablation. However, current photothermal agents (PTAs) derived from exogenous materials have poor tumor targeting and short circulation time. This study developed a pH-responsive nanoprobe, created by coating cancer cell membranes onto polydopamine (PDA)-CaCO3 nanoparticles (CPCaNPs), for image-guided PTT. The CPCaNPs showed enhanced ultrasonic signals and efficient PTT of primary tumors in the acidic microenvironment. Additionally, combining immune checkpoint pathway blockade significantly inhibited tumor recurrence and metastasis. These biomimetic pH-responsive CPCaNPs show great potential for clinical translation in precise PTT immunotherapy.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Nanoscience & Nanotechnology

Immunoinducible Carbon Dot-Incorporated Hydrogels as a Photothermal-Derived Antigen Depot to Trigger a Robust Antitumor Immune Response

Suwan Liu et al.

Summary: The study developed an immunoinducible material using carbon dots and hydrogel, which induced immunogenic tumor cell death and enhanced the maturation and antigen presentation ability of immune cells through photothermal therapy.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Chemistry, Multidisciplinary

Protease-Activatable Nanozyme with Photoacoustic and Tumor-Enhanced Magnetic Resonance Imaging for Photothermal Ferroptosis Cancer Therapy

Wen Qin et al.

Summary: This study presents a novel activatable ferrous nanotheranostics for spatial-temporal control over antitumor ferroptosis responses. The nanotherapeutics can be guided by photoacoustic and magnetic resonance imaging (MRI), and it can effectively induce tumor cell death through photothermal therapy and Fenton reaction. This treatment not only suppresses tumor growth, but also promotes immune response against the tumor.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Checkpoint Nano-PROTACs for Activatable Cancer Photo-Immunotherapy

Chi Zhang et al.

Summary: This study reports the use of checkpoint nano-PROTACs combined with photodynamic tumor regression and immunosuppressive protein degradation to block checkpoint signaling pathways for activatable cancer photo-immunotherapy. The nano-PROTACs consist of a photosensitizer and an SHP2-targeting PROTAC peptide connected by a caspase 3-cleavable segment. By degrading SHP2, these nano-PROTACs can block immunosuppressive checkpoint signaling pathways and enhance antitumor immune response. This study represents a generalized PROTAC platform to modulate immune-related signaling pathways for improved anticancer therapy.

ADVANCED MATERIALS (2023)

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Review Chemistry, Physical

Advanced Biomaterials with Intrinsic Immunomodulation Effects for Cancer Immunotherapy

Weizhi Chen et al.

Summary: Tumor immunotherapy has made significant progress in tumor treatment, but a large proportion of patients do not respond to it. Recent studies have discovered immunoregulatory effects of certain biomaterials, which can be easily modified and customized. This review summarizes the advances in using these immunoregulatory biomaterials in cancer immunotherapy and their interactions with cancer cells and the tumor microenvironment. The opportunities, challenges, and future prospects of using immunoregulatory biomaterials in clinical practice are also discussed.

SMALL METHODS (2023)

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Review Biochemistry & Molecular Biology

Modulating Glycolysis to Improve Cancer Therapy

Chaithanya Chelakkot et al.

Summary: Cancer cells undergo metabolic reprogramming to adopt a glycolysis-dominant metabolic profile, providing them with a survival advantage and contributing to a pro-cancerous tumor environment. This metabolic switch also leads to increased resistance to chemotherapy and radiation. Immune cells in the tumor microenvironment also exhibit a similar metabolic shift, leading to competition with cancer cells for nutrients. Targeting enhanced glycolysis in cancer cells has shown promise in improving treatment efficacy, but effective strategies are still lacking. This review highlights the importance of metabolic reprogramming in cancer cells and the potential of targeting it to enhance conventional cancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Huaixin Zhao et al.

Summary: A DNA nanocomplex is developed for photodynamic therapy (PDT) in breast cancer, enabling tumor-site glutathione-activated therapy without the need for external laser excitation. The nanocomplex integrates persistent-luminescence nanoparticles (PLNPs) as a self-illuminant to activate a photosensitizer and inhibit tumor growth through the production of cytotoxic oxygen.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

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Wenjuan Ma et al.

Summary: DNA materials have been used as nanocarriers for targeted cancer therapy, but their short half-life and low bioavailability hinder their clinical translation. This study developed a HER2-targeted DNA-aptamer-modified DNA tetrahedron/DM1 conjugate, and applied a biomimetic camouflage to enhance drug delivery and tumor-stimulated drug release. The hybrid erythrosome-based nanoparticles exhibited superior inhibition of HER2-positive cancer.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Reshaping the Tumor Immune Microenvironment Based on a Light-Activated Nanoplatform for Efficient Cancer Therapy

Zebin Yang et al.

Summary: This study has constructed a novel nanomaterial to reshape the immunosuppressive tumor microenvironment. The nanomaterial can generate reactive oxygen species to alleviate tumor hypoxia and promote the polarization of tumor-associated macrophages. The light-activated nanoplatform can activate and recruit immune cells in combination with radiotherapy, reversing the immunosuppressive tumor microenvironment and enhancing immune responses.

ADVANCED MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook

Haidong Li et al.

Summary: The discovery of hemicyanine dyes as near-infrared fluorescent chromophores has significant implications in detection, bioimaging, and medical therapeutic applications. These dyes possess superior optical properties and structural tailorability, making them promising tools for monitoring biomolecules and diagnosing diseases.

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Article Biophysics

Synergistic chemo-photothermal cancer therapy of pH-responsive polymeric nanoparticles loaded IR825 and DTX with charge-reversal property

Xiaowei Wang et al.

Summary: The study introduces an intelligent polymer drug carrier based on pH-responsive charge-reversal, which delivers drugs for chemo-photothermal combination therapy, leading to enhanced efficacy in tumor treatment.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

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Article Engineering, Biomedical

A Unique Multifunctional Nanoenzyme Tailored for Triggering Tumor Microenvironment Activated NIR-II Photoacoustic Imaging and Chemodynamic/Photothermal Combined Therapy

Shulong Wang et al.

Summary: The Ox-POM@Cu nanocomposite demonstrates unique enzymatic functions in the tumor microenvironment, including multi-element catalytic activity and NIR-II photoacoustic imaging capabilities. By reacting with glutathione and hydrogen peroxide, it performs photothermal therapy and chemodynamic therapy functions, effectively diagnosing and treating malignant tumors.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Dynamic Adjust of Non-Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR-II Imaging Mediated Photothermal Therapy and Immunotherapy

Zhenjie Wang et al.

Summary: Due to limitations in aggregation-caused quenching effect and poor penetration capabilities in common fluorescent molecules, their applications in visualized imaging and photoactivated treatment are restricted. To overcome this, a new near-infrared II (NIR-II) molecule named TST, which possesses aggregation-induced emission (AIE) and photothermal therapy abilities, is synthesized. The molecule is co-assembled with camptothecin prodrug (CPT-S-PEG) and immune checkpoint inhibitor AZD4635 into nanoparticles for drug delivery, aiming to enhance fluorescent yield and therapeutic effect.

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Review Chemistry, Multidisciplinary

Tumor-Microenvironment-Responsive Nanomedicine for Enhanced Cancer Immunotherapy

Shaojun Peng et al.

Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.

ADVANCED SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

pH-Sensitive and Charge-Reversal Polymeric Nanoplatform Enhanced Photothermal/Photodynamic Synergistic Therapy for Breast Cancer

Wenyan Wang et al.

Summary: This study developed a charge-reversal nanoplatform that utilized pH-responsive and charge-reversal properties to enhance the therapeutic efficacy of photothermal/photodynamic synergistic therapy for breast cancer.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Chemistry, Physical

The Intracellular and Extracellular Microenvironment of Tumor Site: The Trigger of Stimuli-Responsive Drug Delivery Systems

Xiaodong Jing et al.

Summary: The tumor microenvironment contains abnormal biochemical indicators that accelerate tumor heterogeneity. However, these indicators also provide opportunities for designing intelligent drug delivery systems, potentially improving the effectiveness of chemotherapy and reducing side effects.

SMALL METHODS (2022)

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Article Chemistry, Multidisciplinary

Enzyme-Engineered Conjugated Polymer Nanoplatform for Activatable Companion Diagnostics and Multistage Augmented Synergistic Therapy

Jiayingzi Wu et al.

Summary: This study presents a glucose oxidase-engineered nanoplatform for activatable imaging-based companion diagnostics and multistage augmented photothermal/starvation synergistic therapy. The nanoplatform utilizes a pH-activatable conjugated polymer as a photothermal converter and photoacoustic emitter, glucose oxidase as a cancer starvation inducer, and a H2O2-cleavable linker as a switch for enzyme activity. The in vivo imaging and therapy abilities are activated by the acidic tumor microenvironment and self-augmented by the reaction between glucose oxidase and glucose.

ADVANCED MATERIALS (2022)

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Article Biophysics

Plasmon-enhanced biosensors for microRNA analysis and cancer diagnosis

Xiaohui Lu et al.

Summary: MicroRNAs are reliable biomarkers for noninvasive detection of diseases, including cancers. Plasmon-enhanced biosensors are promising tools for miRNA analysis, using enhanced optical output to detect and analyze miRNA.

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Review Oncology

Cancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures

Bing Feng et al.

Summary: Cancer-associated fibroblasts (CAFs) play critical roles in the tumor microenvironment, including extracellular matrix remodeling, metabolic modulation, and angiogenesis. They interact with cancer cells and immune cells through the production of growth factors, cytokines, and chemokines. CAFs have the potential to modulate the sensitivity of anti-cancer therapies, making them potential targets for optimizing cancer treatments.

CANCER CELL INTERNATIONAL (2022)

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Review Biochemistry & Molecular Biology

Exosomal and Non-Exosomal MicroRNAs: New Kids on the Block for Cancer Therapy

Shahzad Nawaz Syed et al.

Summary: This review discusses the potential of MicroRNAs as tools for cancer diagnosis, prognosis, and therapy. The release of miRs into the tumor microenvironment can have both pro- and anti-tumor effects, depending on their source and target cells. The understanding of exosomal and non-exosomal miRs in cancer has provided new insights for potential therapeutic strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Multidisciplinary

ATP-Triggered Intracellular In Situ Aggregation of a Gold-Nanoparticle-Equipped Triple-Helix Molecular Switch for Fluorescence Imaging and Photothermal Tumor Therapy

Yao Jiang et al.

Summary: In this study, a nanoscale probe was constructed for tumor imaging and photothermal therapy (PTT) by utilizing MUC1 aptamer-guided targeting and ATP-induced aggregation of nanoparticles. The designed nanoscale probe shows promising applications in tumor imaging and PTT.

LANGMUIR (2022)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide Biology and Its Role in Cancer

Saadullah Khattak et al.

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MOLECULES (2022)

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Article Chemistry, Multidisciplinary

NIR-II Responsive Molybdenum Dioxide Nanosystem Manipulating Cellular Immunogenicity for Enhanced Tumor Photoimmunotherapy

Peilin Lan et al.

Summary: A new nanosystem for tumor photoimmunotherapy in the second near-infrared window has been developed. This system uses molybdenum dioxide nanodumbbells as nanoconverters and incorporates an apoptosis-blocking strategy to improve immunogenic cell death. The system effectively activates systemic immunity to inhibit tumor growth and metastasis and enhances responses to immune checkpoint inhibitors.

NANO LETTERS (2022)

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Review Chemistry, Multidisciplinary

Recent Advances in Electrochemical Sensing of Hydrogen Peroxide (H2O2) Released from Cancer Cells

Touqeer Ahmad et al.

Summary: Cancer is the leading cause of death globally, with early diagnosis being crucial for treatment success. Recent advancements in cancer diagnosis using nanotechnology focus on the detection of H2O2. The application of new electrochemical biosensors may aid in the early detection of cancer cells.

NANOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

Targeting the Negative Feedback of Adenosine-A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy

Yiqiong Liu et al.

Summary: The study highlights the important role of the adenosine-A2AR metabolic pathway in photothermal-induced immunogenic cell death, and targeting this pathway may achieve effective immunotherapy. The designed nanocarrier can release A2AR inhibitors in the acidic tumor microenvironment, promoting immune cell activation, increasing CD8(+) T lymphocyte infiltration, and reducing myeloid-derived suppressor cell (MDSC) population.

ADVANCED SCIENCE (2022)

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Review Immunology

Interaction Between microRNAs and Myeloid-Derived Suppressor Cells in Tumor Microenvironment

Lifei Liang et al.

Summary: This review summarizes and discusses the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment, revealing the impact of miRNAs and MDSCs on tumor immune escape and metastasis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy

Renye Yue et al.

Summary: A tumor-microenvironment-targeted and co-activated catalytic nanoplatform (CACN) has been developed for specific ferroptosis treatment of cancer cells or tumors. The catalytic activity of CACN can be turned on by dual stimuli of ATP and slight acidity in the tumor microenvironment. The switchable MRI signal of CACN is correlated with reactive oxygen species generation and drug release, allowing for monitoring the therapeutic process.

CHEM (2022)

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Review Biochemistry & Molecular Biology

Delivery of Theranostic Nanoparticles to Various Cancers by Means of Integrin-Binding Peptides

Elena A. Egorova et al.

Summary: Active targeting of tumors is crucial for efficient cancer therapy and accurate diagnostics. Integrin receptors have been studied as a target for cancer treatment for many years. By decorating nanoparticles with integrin-targeting peptides, the accumulation of nanoparticles in tumors can be significantly increased.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Multidisciplinary

Semiconducting Polymer Nanoparticles with Surface-Mimicking Protein Secondary Structure as Lysosome-Targeting Chimaeras for Self-Synergistic Cancer Immunotherapy

Ji Qi et al.

Summary: This study developed a new type of nanoparticles (SPSS NPs) that can achieve self-synergistic cancer immunotherapy by combining immunogenic cell death (ICD) and immune checkpoint blockade therapy. The nanoparticles can trigger a strong anti-tumor immune response and generate long-term immune memory against tumor rechallenge.

ADVANCED MATERIALS (2022)

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Review Pharmacology & Pharmacy

Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

Yanyan Xu et al.

Summary: Cancer immunotherapy has flourished and revolutionized tumor therapies, but challenges such as low patient response rates and immune-related side effects remain. The immunosuppressive tumor microenvironment (TME) plays a pivotal role in tumor progression and metastasis, but also provides targets for remodeling the TME. Remodeling the TME and strengthening patients' immune systems can improve the effectiveness of immunotherapy.

ACTA PHARMACEUTICA SINICA B (2022)

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Interplay between Solid Tumors and Tumor Microenvironment

Seung-Jin Kim et al.

Summary: This article discusses the process of tumors adapting to adverse environments through communication with neighboring cells. Understanding the physiology of these tumors and their interaction with the tumor environment can help in developing promising tumor treatment strategies.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Fight the Cancer, Hit the CAF!

Andrea Papait et al.

Summary: The tumor microenvironment (TME) has gained increasing interest in the field of therapeutics in the past 20 years. Specifically, cancer-associated fibroblasts (CAF) have attracted attention due to their ability to promote tumor progression and metastasis. This review provides an overview of the latest discoveries regarding CAF, including their characterization and their impact on the immune system. Clinical trials and preclinical studies targeting CAF have shown controversial results, highlighting the need for further understanding of the functional properties of different CAF subtypes in specific pathological contexts.

CANCERS (2022)

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Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment

Iljin Kim et al.

Summary: Cancers have regions of low oxygen concentration that activate hypoxia-related signaling pathways. Fibroblasts, one of the most abundant cellular components in the tumor stroma, are significantly affected by oxygen deprivation. This article summarizes the molecular and cellular mechanisms that regulate fibroblasts under hypoxic conditions and their impact on cancer development and progression. It also discusses potential therapeutic strategies targeting fibroblasts in the hypoxic tumor microenvironment.

CANCERS (2022)

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Review Biochemistry & Molecular Biology

Modulation of reactive oxygen species in cancers: recent advances

Jeyasree M. Ganesh et al.

Summary: Oxidation-reduction reactions have played a significant role in the chemical evolution of life forms. Reactive oxygen species (ROS) play an important role in cellular signaling, but high levels of ROS can cause severe damage to tissues. Elevated and chronic levels of ROS are associated with carcinogenesis, and some therapies rely on altering ROS levels to eliminate tumor cells. The effective modulation of ROS levels has been a focal point in recent research.

FREE RADICAL RESEARCH (2022)

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Review Chemistry, Multidisciplinary

Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment

Tang Hailing et al.

Summary: Abnormal regulation of cell signaling pathways on cell survival, proliferation, and migration contributes to the development of malignant tumors. Epidermal growth factor receptor (EGFR) is an important biomarker in many types of malignant solid tumors. GE11 peptide, a potent EGFR ligand, has been widely used in diagnosis and targeted drug delivery for EGFR-positive tumors. This review provides valuable insights into the factors affecting the targeting performance of GE11 peptide and its applications in cancer treatment.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Biochemistry & Molecular Biology

Antioxidants in brain tumors: current therapeutic significance and future prospects

Xuchen Qi et al.

Summary: Brain cancer is one of the most deadly forms of cancer, and brain tumor cells are resistant to conventional and advanced therapies. Antioxidants may prevent tumorigenesis by inhibiting oxidative stress and have chemopreventive and chemotherapeutic effects on brain cancers. They can also minimize chemotherapy-induced toxicity and reverse chemoresistance. However, the effects of antioxidants depend on various factors and conditions, and more mechanistic studies are needed for consistent clinical outcomes.

MOLECULAR CANCER (2022)

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Review Pharmacology & Pharmacy

The intricate interplay between HIFs, ROS, and the ubiquitin system in the tumor hypoxic microenvironment

Yijie Wang et al.

Summary: Alterations in protein ubiquitination and HIF signaling contribute to tumorigenesis and tumor progression. ROS upregulation in tumors has multiple effects on HIF signaling and the ubiquitin system. Multiple E3 ligases and UBDs work together to regulate the expression and activity of HIF, helping cancer cells cope with hypoxia. Understanding the complex networks between E3 ligase, UBDs, ROS, and HIF provides insights into the cellular response to hypoxia and identifies novel molecular targets for cancer treatment.

PHARMACOLOGY & THERAPEUTICS (2022)

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Article Chemistry, Analytical

A NTR and O2 programmed responsive photogenic radicals for efficient hypoxia cancer therapy

Fengfeng Xue et al.

Summary: A novel photosensitizer, activated by nitroreductase, was developed for precise and efficient photodynamic therapy of hypoxic tumors. In vitro and in vivo results demonstrate its high specificity and selectivity for hypoxic solid tumors, presenting promising prospects for clinical cancer phototherapy.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Review Physiology

NRF2: A crucial regulator for mitochondrial metabolic shift and prostate cancer progression

Brigitta Buttari et al.

Summary: Metabolic alterations are common survival mechanism for prostate cancer, with oxidative stress in the cellular and tumor microenvironment dictating metabolic switching in cancer cells. Regulation of oxidative stress may enhance conventional anticancer therapies.

FRONTIERS IN PHYSIOLOGY (2022)

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Review Oncology

The Role of miR-155 in Antitumor Immunity

Katerina Kalkusova et al.

Summary: MiR-155 is a significant regulator of immune responses against tumors, particularly in different immune cell populations, and it can impact the process of cancer immunoediting. Its role in cellular communication is also important. MiR-155 targeting is increasingly used in cancer immunotherapy.

CANCERS (2022)

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Review Chemistry, Multidisciplinary

Biodistribution, degradability and clearance of 2D materials for their biomedical applications

Taojian Fan et al.

Summary: Two-dimensional materials have shown great potential in the biomedical field, but their clinical translation is limited by potential side effects and safety concerns. To achieve maximum therapeutic efficacy with minimum adverse effects, targeted delivery and sufficient degradation and clearance rates of 2D materials are essential. Understanding the biodistribution and destiny of 2D materials in vivo is crucial for their successful application.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Tumor microenvironment responsive nanocarriers for gene therapy

Yanhua Li et al.

Summary: This article discusses the significance of stimuli responsive nanocarriers as non-viral gene carriers for gene therapy. It specifically highlights the application of various stimuli responsive nanocarriers in the tumor microenvironment for cancer gene therapy.

CHEMICAL COMMUNICATIONS (2022)

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A dynamic DNA nanosponge for triggered amplification of gene-photodynamic modulation

Dan Luo et al.

Summary: DNAzyme-mediated gene regulation and photodynamic cancer therapy achieved using dynamic DNA nanomaterials with self-enhanced efficacy, providing a potential therapeutic approach for gene modulation.

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Breaking Immunosuppressive Barriers by Engineered Nanoplatforms for Turning Cold Tumor to Hot

Jingwen Dong et al.

Summary: This article reviews the potential of engineered nanoplatforms (ENs) in overcoming immunosuppressive barriers in cancer immunotherapy. The strategies of converting poor immunogenicity, alleviating tumor fibrosis, and reducing immunosuppressive factors are discussed, and future directions and challenges are presented.

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Highly photostable croconium dye-anchored cell membrane vesicle for tumor pH-responsive duplex imaging-guided photothermal therapy

Xiaoting Gao et al.

Summary: The research focused on developing tumor acidic microenvironment-responsive theranostic agents. The highly photostable amphiphilic croconium dye-anchored red blood cell membrane vesicle (LET-5) showed enhanced NIRF and PA signals in the tumor acidic microenvironment, along with activated photothermal effect. The use of cell membrane-based vesicles improved the stability and blood circulation of the drug, resulting in better therapeutic outcomes in tumor treatment.

BIOMATERIALS (2021)

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Article Nanoscience & Nanotechnology

Intelligent Tumor Microenvironment-Activated Multifunctional Nanoplatform Coupled with Turn-on and Always-on Fluorescence Probes for Imaging-Guided Cancer Treatment

Yudong Sun et al.

Summary: A TME-responsive nanoplatform was designed for imaging-guided photodynamic/chemodynamic/photothermal therapy through a simple biomineralization method. This nanosystem showed enhanced efficacy and provided a versatile strategy for multiple imaging-guided theranostic applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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NO-releasing polypeptide nanocomposites reverse cancer multidrug resistance via triple therapies

Yue Ding et al.

Summary: A NIR/pH dual-sensitive charge-reversal polypeptide nanocomposite was developed for co-delivering a nitric oxide donor and doxorubicin, providing an effective strategy for overcoming multidrug resistance.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Effective Eradication of Tumors by Enhancing Photoacoustic-Imaging-Guided Combined Photothermal Therapy and Ultrasonic Therapy

Caina Xu et al.

Summary: This study introduces two versatile nanoparticles, mPEG-PEI-AuNRs and mPEG-PEI/CaNPs, which possess favorable properties such as high cell uptake, efficient accumulation, and generation of carbon dioxide bubbles. By combining near-infrared laser and ultrasonic irradiation, these nanoparticles effectively achieve photothermal therapy and ultrasonic therapy for tumor eradication.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Second Near-Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Jingchao Li et al.

Summary: This study introduces a novel semiconducting polymer nanoadjuvant for second NIR-II photothermal immunotherapy, which effectively inhibits tumor growth and eliminates metastasis through a combination of photothermal conversion and TLR agonist release.

ADVANCED MATERIALS (2021)

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Review Medicine, Research & Experimental

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Sreya Bagchi et al.

Summary: This article highlights the significance of immune checkpoint inhibitors in cancer immunotherapy and the research findings on the changes in local and systemic immune cells after treatment. It emphasizes the need for understanding the requirements for an effective and safe antitumor immune response following ICI therapy.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

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Article Engineering, Environmental

Structure transformable nanoparticles for photoacoustic imaging-guided photothermal ablation of tumors via enzyme-induced multistage delivery

Xianlei Li et al.

Summary: Researchers have developed transformable CuS@GNPs nanoparticles that can undergo enzyme-induced multistage delivery, leading to enhanced accumulation at the tumor site and deeper penetration.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Physical

A Tumor Microenvironment-Triggered and Photothermal-Enhanced Nanocatalysis Multimodal Therapy Platform for Precise Cancer Therapy

Ling Qiao et al.

Summary: This study presents a TME-triggered and PT-enhanced nanocatalysis platform based on cancer cell membrane-camouflaged hollow porous Cu7S4 nanospheres for efficient cancer therapy. The platform can be used for photothermal therapy and catalyze the generation of reactive oxygen species and hydrogen sulfide under TME conditions. NIR irradiation further enhances the therapeutic efficiency of this multimodal therapeutic strategy.

CHEMISTRY OF MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Charge-reversal biodegradable MSNs for tumor synergetic chemo/ photothermal and visualized therapy

Zimu Li et al.

Summary: A novel nanomedicine, MSN-Man-DOX@PDA-Gd-PEOz, was developed with excellent tumor targeting and penetration abilities, showing outstanding therapeutic effects in vivo and a promising prospect for clinical application.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Physical

A Nonenzymatic Hydrogen Peroxide Electrochemical Sensing and Application in Cancer Diagnosis

Yan Yu et al.

Summary: The study presents a biologically sensitive and efficient H2O2 electrochemical sensor based on PtNi nanoparticle-doped N-reduced graphene oxide, which successfully captures H2O2 from cancer cells and efficiently detects tumor tissues. This technique provides a complementary method for pathological tumor diagnosis independent of traditional pathology labs.

SMALL METHODS (2021)

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Article Chemistry, Multidisciplinary

Renal-Clearable Ultrasmall Polypyrrole Nanoparticles with Size-Regulated Property for Second Near-Infrared Light-Mediated Photothermal Therapy

Weiwei Zeng et al.

Summary: The challenge of potential toxicity and renal clearance hinders the translation of nanomaterials into medical applications. Researchers have developed ultrasmall polypyrrole nanoparticles with multimodal imaging and photothermal therapeutic effects, which can effectively eliminate tumors with minimal systemic toxicity.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Manganese-Dioxide-Coating-Instructed Plasmonic Modulation of Gold Nanorods for Activatable Duplex-Imaging-Guided NIR-II Photothermal-Chemodynamic Therapy

Ting He et al.

Summary: A plasmonic modulation strategy of gold nanorods through manganese dioxide coating has been developed for NIR-II photoacoustic/magnetic resonance imaging-guided photothermal chemodynamic therapy. The LSPR peak of gold nanorods can be tuned by adjusting the thickness of the MnO2 layer, and the MnO2 layer can degrade in the tumor microenvironment for MR imaging and chemodynamic therapy. This strategy can be applied to other metal nanomaterials for construction of a new class of NIR-II nanotheranostics.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy

Jinsheng Huang et al.

Summary: A novel nanocarrier was developed for tumor-targeted delivery in melanoma to activate anti-tumor immunity and reduce adverse effects. Additionally, combining sonodynamic therapy with immunotherapy effectively promotes anti-cancer immunity and suppresses melanoma growth.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Glutathione-mediated nanomedicines for cancer diagnosis and therapy

Yiming Ding et al.

Summary: This review firstly analyzed the characteristics and functions of GSH in normal and cancer cells, then comprehensively summarized the recent advances in GSH-mediated nanomedicines for cancer diagnosis and therapy, discussing different strategies and proposing future perspectives and challenges in this field.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Polymers and inorganic nanoparticles: A winning combination towards assembled nanostructures for cancer imaging and therapy

Kuikun Yang et al.

Summary: The combination of inorganic nanoparticles and organic polymers in nanosized assemblies creates synergistically enhanced properties that hold great potential for cancer imaging and therapy.

NANO TODAY (2021)

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Review Nanoscience & Nanotechnology

Targeted drug delivery strategies for precision medicines

Mandana T. Manzari et al.

Summary: Precision medicine offers personalized treatment strategies for individual patients, especially in the field of cancer therapy. While there have been some clinical successes, challenges such as drug toxicities and resistance still hinder the full potential of precision medicine. Advanced drug delivery materials and approaches provide opportunities to improve therapeutic outcomes and overcome pharmacological issues in cancer treatment.

NATURE REVIEWS MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Multi-Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors

Xin Li et al.

Summary: In this study, intelligent cationic NGs with tunable responsiveness, versatility, and biodegradation are developed for precision medicine applications. By utilizing modular design and engineered strategy, NGs with different responsiveness and functionalities are prepared, including hybrid NGs with high photothermal conversion efficiency and drug release properties combined with photothermal-chemotherapy.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Engineering, Biomedical

Recent progress in drug delivery and cancer theranostic built from metal-organic framework

Peng Yang et al.

Summary: This review summarizes the research progress in designing DDS and CTA using metal-organic frameworks (MOF), showing the simplicity, control, and versatility of these materials for cancer treatment and providing prospects for the development of MOF-based nanomedicine in the future.

BIOMEDICAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Light-Activated Hypoxia-Sensitive Covalent Organic Framework for Tandem-Responsive Drug Delivery

Lei Ge et al.

Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

pH/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy

Xian Tang et al.

Summary: A tumor-targeting and rapid gene release nano-courier based on phenylboronic acid (PBA) was constructed to enhance photothermal therapy by delivering PD-L1 siRNA. The nano-courier could effectively penetrate and be taken up by tumors with overexpressed sialic acid residues, leading to efficient PD-L1 silencing and triggering systemic antitumor immune responses, ultimately resulting in the complete ablation of orthotopic tumors and suppression of metastasis and recurrence.

NANO TODAY (2021)

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Review Medical Laboratory Technology

miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer

Shen Zhong et al.

Summary: Blood-borne miR-20a, miR-10b, miR-150, and miR-223 were identified as excellent diagnostic biomarkers for non-small cell lung cancer, while miR205 showed specificity for squamous cell carcinoma. Additionally, a systematic review revealed 38 commonly regulated miRNAs in tumor tissue and circulation, enabling the prediction of histological subtypes of LC.

TRANSLATIONAL RESEARCH (2021)

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Review Nanoscience & Nanotechnology

Multifunctional biomolecule nanostructures for cancer therapy

Jing Wang et al.

Summary: This review discusses the application of biomolecule-based nanostructures in smart cancer nanomedicine. These multifunctional nanostructures, including polysaccharides, nucleic acids, peptides, and proteins, can achieve targeted drug delivery and transport drugs to tumor tissues.

NATURE REVIEWS MATERIALS (2021)

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Article Multidisciplinary Sciences

A tumor microenvironment-induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

Shulong Wang et al.

Summary: The study found that the GSH level significantly increases in tumor tissues, thus it can be used as an endogenous molecule for diagnosing and treating tumors. The Fe-Cu@PANI nanoparticles prepared in the study utilize the tumor microenvironment-induced properties to activate tumor photoacoustic imaging and photothermal therapy in vivo, enhancing the efficiency of treatment.

SCIENCE ADVANCES (2021)

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Review Pharmacology & Pharmacy

CAR-T cells: Early successes in blood cancer and challenges in solid tumors

Hassan Dana et al.

Summary: New approaches in cancer immunotherapy, such as checkpoint inhibitors for solid tumors and CAR-T cell therapy for hematologic malignancies, have shown promising results. While CAR-T products have demonstrated powerful effects against B cell cancers, challenges exist in using them for solid tumors.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Chemistry, Multidisciplinary

Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of Small-Interfering RNA and Antisense Oligonucleotide

Lei Chen et al.

Summary: This study developed a PSNA for carrier-free and NIR photocontrolled self-delivery of siRNA and ASO, which could selectively release therapeutic agents in tumor cells under NIR light irradiation. PSNA showed promising potential for cancer therapy by combining gene therapy and photodynamic therapy.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Ruthenium (II)-Coordinated Supramolecular Metallodrug Complex Realizing Oxygen Self-Supply In Situ for Overcoming Hypoxic Tumors

Chengfei Liu et al.

Summary: A stable and efficient in-situ oxygen self-supply system for hypoxic tumors is proposed using organometallic drug complexes with a supramolecular interaction strategy. The ruthenium (II)-coordinated supramolecular metallodrug complex (RuSMDC) is designed to produce oxygen by catalyzing the decomposition of hydrogen peroxide, leading to improved therapeutic effects of chemotherapy and photodynamic therapy oncotherapy in anaerobic tumor environments. Further studies confirm that Ru-containing supramolecular metallodrug micelles effectively alleviate the tumor hypoxic environment and reduce systemic toxicity.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

GSH-Depleted Nanozymes with Dual-Radicals Enzyme Activities for Tumor Synergic Therapy

Shengming Wu et al.

Summary: Developing a novel nanocatalyst platform involving longer half-life time ROS is desired to enhance tumor therapy efficacy. Fe3O4-Schwertmannite nanocomposites with triple-effect tumor therapy were successfully constructed, exhibiting remarkable tumor inhibition both in vitro and in vivo. The comprehensive properties of the nanoplatform, including dual-radical production, Fe3O4 nanocrystal mediated PTT, and the BSO mediated GSH depletion, pave a way to constructing a synergic catalytic nanoplatform for efficient tumor therapy.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Analytical

Gold-Bipyramid-Based Nanothernostics: FRET-Mediated Protein-Specific Sialylation Visualization and Oxygen-Augmenting Phototherapy against Hypoxic Tumor

Xing Zhang et al.

Summary: The study introduces a versatile nanoprobe APT that combines FRET and oxygen-augmenting strategy, enabling glycosylation detection, O-2 self-sufficiency, and collaborative phototherapy, showing significant therapeutic advantages against hypoxic tumors.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Analytical

Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors

Xiaju Cheng et al.

Summary: A novel strategy of furin enzyme/acidic pH-triggered small gold nanoparticle aggregation was reported for activating photoacoustic imaging and photothermal functions in vivo, enhancing the diagnostic and therapeutic efficacy of tumors.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

A Titanium Nitride Nanozyme for pH-Responsive and Irradiation-Enhanced Cascade-Catalytic Tumor Therapy

Jiaming Liu et al.

Summary: The study found that nitrogen doping significantly enhanced the peroxidase activity of titanium-based nanozymes, and further improved the catalytic activity of nanozymes under near-infrared laser irradiation. By using TLGp, combining pH-responsive GOx-mediated H2O2 self-supply, nitrogen doping, and irradiation-enhanced enzymatic activity of titanium nitride nanoparticles, along with mild photothermal therapy, effective tumor inhibition with minimal side effects in vivo was achieved.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Ultrathin chalcogenide nanosheets for photoacoustic imaging-guided synergistic photothermal/gas therapy

Jingjing Wu et al.

Summary: A copper-loaded CoCuFe-selenide nanocomposite with synergistic photothermal and gas therapy effects was prepared, releasing NO gas in the tumor microenvironment for targeted treatment. In vitro and in vivo experiments demonstrated its efficacy in tumor elimination.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Hierarchical nano-to-molecular disassembly of boron dipyrromethene nanoparticles for enhanced tumor penetration and activatable photodynamic therapy

Yonghe Zhang et al.

Summary: The development of boron dipyrromethene (BDP)-based nanoparticles for activatable photodynamic therapy (PDT) shows promising results in achieving tumor penetration and specific recognition by cancer cells, while also allowing for efficient disassembly into single PS molecules for effective PDT under acidic conditions.

BIOMATERIALS (2021)

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Article Engineering, Environmental

Glutathione-activated DNA-Au nanomachine as targeted drug delivery platform for imaging-guided combinational cancer therapy

Kaixin Yu et al.

Summary: The development of a multifunctional DNA-Au nanomachine in this study enables targeted cancer cell recognition and delivery of anti-cancer drugs, achieving efficient combination therapy for breast cancer.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Chemistry, Multidisciplinary

Recent advances in enhanced chemodynamic therapy strategies

Qiwei Tian et al.

Summary: Chemodynamic therapy (CDT) is a novel therapeutic modality that aims to destroy cancer cells using Fenton reactions without external energy input. Various strategies have been explored to enhance the efficiency of CDT, including increasing the production, accelerating generation, and enhancing efficacy of hydroxyl radicals.

NANO TODAY (2021)

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Article Chemistry, Multidisciplinary

Redox-activatable photothermal therapy and enzyme-mediated tumor starvation for synergistic cancer therapy

Xinlong He et al.

Summary: This study developed a multifunctional cascade nanoreactor for synergistic cancer therapy combining starvation therapy (ST) and photothermal therapy (PTT). The nanoreactor effectively inhibited tumor cell growth by blocking ATP generation, increasing HSP-70 levels, and improving the hypoxic state of the tumor microenvironment.

NANO TODAY (2021)

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Review Nanoscience & Nanotechnology

The current landscape of nucleic acid therapeutics

Jayesh A. Kulkarni et al.

Summary: The increasing number of approved nucleic acid therapeutics demonstrates their potential for long-lasting or curative effects by targeting genetic blueprints; however, their clinical translation relies on advances in delivery technologies. Four platform technologies, including antisense oligonucleotides, small interfering RNA conjugates, lipid nanoparticles, and adeno-associated virus vectors, have enabled the clinical translation of nucleic acid therapeutics, leading to the approval of cutting-edge genetic drugs.

NATURE NANOTECHNOLOGY (2021)

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Review Oncology

Therapeutic targeting of the hypoxic tumour microenvironment

Dean C. Singleton et al.

Summary: The article discusses the relationship between two different tumor microenvironment research fields: physicochemical gradients and cellular interactions, with a focus on translational therapeutic opportunities. Hypoxia is a common feature of tumors, influencing various cancer characteristics and responses to anticancer therapies.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Catalase Nanocrystals Loaded with Methylene Blue as Oxygen Self-Supplied, Imaging-Guided Platform for Photodynamic Therapy of Hypoxic Tumors

Renbin Zhou et al.

Summary: Using CatCry as an oxygen-generating system can effectively alleviate tumor hypoxia and enhance PDT efficiency. The CatCry-MB drug platform significantly enhances PDT efficiency through three mechanisms, including continuous oxygen supply, shortening of diffusion distance between O-2 and MB, and avoidance of MB aggregation.

SMALL (2021)

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Article Oncology

Effect of lncRNA XLOC_005950 knockout by CRISPR/Cas9 gene editing on energy metabolism and proliferation in osteosarcoma MG63 cells mediated by hsa-miR-542-3p

Zhen Jia et al.

Summary: In this study, it was found that lncRNA XLOC_005950 was upregulated in OS tissues and cells. Knockout of lncRNA XLOC_005950 in OS cells led to decreased PFKM activity, intracellular glucose and lactic acid content, reduced cell proliferation, and increased apoptosis. Furthermore, knockout of lncRNA XLOC_005950 upregulated hsa-miR-542-3p expression and downregulated PFKM expression.

ONCOLOGY LETTERS (2021)

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Article Multidisciplinary Sciences

Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy

Na Kong et al.

Summary: The regulation of intracellular ROS levels is crucial for cellular homeostasis and fate determination, with moderate levels promoting cell proliferation and differentiation, and excessive levels inducing apoptosis. Surface-oxidized arsenene nanosheets with engineered modifications serve as an intelligent theranostic platform for cancer therapy, enabling targeted delivery and prolonged circulation for effective treatment.

NATURE COMMUNICATIONS (2021)

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Review Nanoscience & Nanotechnology

Molecular imaging and disease theranostics with renal-clearable optical agents

Penghui Cheng et al.

Summary: Renal-clearable optical agents (RCOAs) are rapidly excreted from the body via the kidneys, making them suitable for targeted kidney imaging and early kidney injury detection, as well as deep tumor penetration and high-contrast tumor imaging.

NATURE REVIEWS MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Nanoparticle-Based Therapies for Turning Cold Tumors Hot: How to Treat an Immunosuppressive Tumor Microenvironment

Giulio Giustarini et al.

Summary: Nanotechnologies are playing a rapidly increasing role in immuno-oncology, particularly in transforming immunologically cold tumors into therapeutically responsive hot tumors.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Influence of Adjunctive Photodynamic Therapy on Interleukin-6, Interleukin-8, and Interleukin-10 Gingival Crevicular Fluid Levels in Chronic Periodontitis - A Randomized Controlled Trial

Vishakha Vilas Kharkar et al.

Summary: The study demonstrated that using PDT as an adjunct to NSPT in the treatment of chronic periodontitis resulted in a significant reduction in bleeding on probing and a decrease in GCF pro-inflammatory cytokine levels.

CONTEMPORARY CLINICAL DENTISTRY (2021)

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Article Chemistry, Multidisciplinary

In situ hydrogen nanogenerator for bimodal imaging guided synergistic photothermal/hydrogen therapies

Guanglong Yuan et al.

Summary: The proposed strategy in this study involves loading aminoborane onto mesoporous polydopamine nanoparticles for hydrogen production, providing a novel approach for developing multifunctional nanosystems with high hydrogen-loading capacity and sustained release ability. The nanosystem not only achieves selective PTT/hydrogen therapies and US/CT bimodal imaging functions, but also shows excellent properties such as biocompatibility, promising as an efficient and safe tumor treatment for future clinical translation.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

MnO2-coated porous Pt@CeO2 core-shell nanostructures for photoacoustic imaging-guided tri-modal cancer therapy

Qing Xu et al.

Summary: The synthesis of MnO2-coated porous Pt@CeO2 core-shell nanostructures (Pt@CeO2@MnO2) offers a new theranostic nano-platform with high photothermal conversion efficiency and multifunctional therapeutic properties. The combination of Pt core and porous CeO2 interlayer allows for photothermal therapy, photoacoustic imaging, and photodynamic therapy. DOX-loaded Pt@CeO2@MnO2 demonstrates remarkable therapeutic outcomes in vitro and in vivo, providing a potential avenue for designing high-performance nano-platforms.

NANOSCALE (2021)

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Review Chemistry, Multidisciplinary

Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

Jianlei Xie et al.

Summary: Photodynamic therapy (PDT) has shown great potential in tumor treatment due to its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability. However, the clinical application of PDT is restricted by various factors such as traditional photosensitizer limitations, light penetration issues, tumor resistance, and pain induction. Recent advancements in using nanomaterials as photosensitizers or carriers, combined with optimized therapy strategies, have shown promising results in overcoming these barriers and improving the effectiveness of PDT in cancer treatment.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Immobilising hairpin DNA-conjugated distyryl boron dipyrromethene on gold@polydopamine core-shell nanorods for microRNA detection and microRNA-mediated photodynamic therapy†

Gaole Dai et al.

Summary: The novel nanosystem designed using polydopamine-coated gold nanorods immobilised with molecules of hairpin DNA-conjugated DSBDP can detect microRNA-21 (miR-21) with high specificity and potent therapeutic potential for miR-21-mediated photodynamic therapy.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment

Qifang Chen et al.

Summary: The nanosystem designed in this study, coated with FDA approved PLGA, Fe3O4, and Ce6, is capable of synergistic ferroptosis-photodynamic anticancer therapy by releasing ferrous/ferric ions and Ce6 in the acidic TME for Fenton reaction and ROS generation under laser irradiation. The nanosystem also possesses excellent MRI properties and highly efficient tumor suppression in vivo due to the synergism of photodynamic and ferroptosis antitumor therapies.

NANOSCALE (2021)

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Article Chemistry, Multidisciplinary

Manganese/iron-based nanoprobes for photodynamic/chemotherapy combination therapy of tumor guided by multimodal imaging

Shanshan Fan et al.

Summary: By synthesizing and loading specific substances, the Fe3O4@MnO2-celastrol/Ce6 nanoplatform can achieve combined imaging and drug release targeting tumor characteristics, optimize chemotherapy and photodynamic therapy, release drugs in the tumor microenvironment, and generate Mn2+ and O-2.

NANOSCALE (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management

Da Huo et al.

ADVANCED MATERIALS (2020)

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Article Oncology

Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain

Xiang Zhuang et al.

CARCINOGENESIS (2020)

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Review Pharmacology & Pharmacy

Stimuli-responsive charge-reversal nano drug delivery system: The promising targeted carriers for tumor therapy

Zengjun Fang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Review Medicine, General & Internal

Tumor Microenvironment

Borros Arneth

MEDICINA-LITHUANIA (2020)

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Article Multidisciplinary Sciences

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Dongdong Wang et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Engineering a Therapy-Induced Immunogenic Cancer Cell Death Amplifier to Boost Systemic Tumor Elimination

Bei Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

GSH and H2O2 Co-Activatable Mitochondria-Targeted Photodynamic Therapy under Normoxia and Hypoxia

Jian Sun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Environmental

Biodegradable theranostic nanoplatforms of albumin-biomineralized nanocomposites modified hollow mesoporous organosilica for photoacoustic imaging guided tumor synergistic therapy

Dejian Li et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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Article Engineering, Biomedical

High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies

Katja Haedicke et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Nanoscience & Nanotechnology

Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy

Yite Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biology

A Cu9S5 nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy

Lulu Zhou et al.

COMMUNICATIONS BIOLOGY (2020)

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Article Nanoscience & Nanotechnology

Rapid Decomposition and Catalytic Cascade Nanoplatforms Based on Enzymes and Mn-Etched Dendritic Mesoporous Silicon for MRI-Guided Synergistic Therapy

Bin Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy

Jianzhi Zhu et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Furin-Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy

Jihua Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Emetine-Loaded Black Phosphorus Hydrogel Sensitizes Tumor to Photothermal Therapy through Inhibition of Stress Granule Formation

Jianlei Xie et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

A Near-Infrared Photo-Switched MicroRNA Amplifier for Precise Photodynamic Therapy of Early-Stage Cancers

Yue Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity

Chu-Hung Chung et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Tumor Microenvironment-Regulated and Reported Nanoparticles for Overcoming the Self-Confinement of Multiple Photodynamic Therapy

Cheng Li et al.

NANO LETTERS (2020)

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Review Chemistry, Multidisciplinary

Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

Fei Gong et al.

NANO TODAY (2020)

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Article Oncology

Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression

Konghe Hu et al.

ONCOLOGY REPORTS (2020)

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Review Chemistry, Multidisciplinary

Retooling Cancer Nanotherapeutics' Entry into Tumors to Alleviate Tumoral Hypoxia

Xiao Sun et al.

SMALL (2020)

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Article Engineering, Biomedical

Nanocomposite hydrogel with NIR/magnet/enzyme multiple responsiveness to accurately manipulate local drugs for on-demand tumor therapy

Pingyun Yuan et al.

BIOMATERIALS (2020)

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Review Biochemistry & Molecular Biology

Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity

Joy X. Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Chemistry, Multidisciplinary

Emerging combination strategies with phototherapy in cancer nanomedicine

Zhongjian Xie et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Enzyme-instructed self-aggregation of Fe3O4 nanoparticles for enhanced MRI T2 imaging and photothermal therapy of tumors

Yaguang Wang et al.

NANOSCALE (2020)

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Review Chemistry, Multidisciplinary

Polymer-guided assembly of inorganic nanoparticles

Chenglin Yi et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Materials Science, Biomaterials

Hypoxia-augmented and photothermally-enhanced ferroptotic therapy with high specificity and efficiency

Peijing An et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Astronomy & Astrophysics

The Effects of Dust Optical Properties on the Scattering-induced Disk Polarization by Millimeter-sized Grains

Haifeng Yang et al.

ASTROPHYSICAL JOURNAL (2020)

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Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Review Chemistry, Multidisciplinary

Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Yijing Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Review Oncology

Acidosis and proteolysis in the tumor microenvironment

Kyungmin Ji et al.

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Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu2-xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer

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