☆ 4.8 Review

Oncolytic Virus-Driven Biotherapies from Bench to Bedside

SMALL (2023)

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Review Pharmacology & Pharmacy

Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid

Shraddha S. Sadekar et al.

Summary: This review summarizes the methods and technologies for delivering biologics to the central nervous system via cerebrospinal fluid. Multiple factors need to be considered to achieve effective therapeutic concentrations, and quantitative models are used to optimize drug delivery to specific brain regions.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Review Chemistry, Physical

Emerging systemic delivery strategies of oncolytic viruses: A key step toward cancer immunotherapy

Weiyue Ban et al.

Summary: Oncolytic virotherapy (OVT) is a novel immunotherapy that utilizes selective self-replication within cancer cells and oncolytic virus (OV)-mediated immunostimulation to induce anti-tumor responses. Recent advancements in systemic delivery of OVs show promise in expanding the scope of cancer immunotherapy and improving OV delivery efficacy. This review summarizes the general characteristics of OVs, discusses the advantages and disadvantages of OVT, and highlights emerging systemic administration approaches and combination treatments with traditional therapies. The future prospects and challenges of OVT are also discussed.

NANO RESEARCH (2022)

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Review Pharmacology & Pharmacy

Improving the ability of CAR-T cells to hit solid tumors: Challenges and strategies

Zheng-Zheng Zhang et al.

Summary: Chimeric antigen receptor T cell (CAR-T) therapy has shown significant progress in the treatment of hematologic malignancies, with higher specificity, stronger lethality, and longer-lasting efficacy compared to traditional anti-tumor methods. However, there are still challenges in the treatment of solid tumors, including immune escape, physical barriers, immunosuppressive molecules, and T cell exhaustion. Modifying intracellular signaling of CAR, coexpressing or knocking out transcription factors, and combining CAR-T cells with other therapies are promising strategies to improve CAR-T cells function.

PHARMACOLOGICAL RESEARCH (2022)

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Review Pharmacology & Pharmacy

Drug delivery across the blood-brain barrier for the treatment of pediatric brain tumors-An update

Erica A. Power et al.

Summary: Although there has been a surge in the identification of molecular targets and targeted therapies in pediatric brain tumors in the last decade, the blood brain barrier (BBB) remains a significant challenge for systemic drug delivery. Recent efforts have identified strategies to enhance drug delivery into pediatric brain tumors, including invasive and non-invasive technologies.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Virology

Rb-E2F-HDAC Repressor Complexes Control Interferon-Induced Repression of Adenovirus To Promote Persistent Infection

Sydney Snaider et al.

Summary: This study uncovers the critical role of pRb and class I HDACs in the IFN-induced formation of a repressor complex that promotes persistent HAdV infections. The mechanism underlying HAdV persistence has not been fully explored. Here, we provide insight into the contributions of the host cell to IFN-mediated persistent HAdV infection.

JOURNAL OF VIROLOGY (2022)

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Article Chemistry, Multidisciplinary

Boarding Oncolytic Viruses onto Tumor-Homing Bacterium-Vessels for Augmented Cancer Immunotherapy

Mengchi Sun et al.

Summary: This study proposes a bacteria-assisted targeting system for oncolytic viruses (OVs) to enhance their concentration within tumors. By conjugating liposome-cloaked oncolytic adenoviruses (OAs) onto tumor-homing Escherichia coli, the enrichment of OAs within tumors is significantly increased. In addition, this system also augments antitumor immune responses through bacterial-viral interactions.

NANO LETTERS (2022)

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Review Oncology

Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment

Lihong Wang et al.

Summary: Tumor cells manipulate the local environment to create a tumor microenvironment (TME) that promotes tumor survival and metastasis. Oncolytic viruses (OVs) are a promising therapeutic approach that can modify the TME to activate antitumor immune cells and overcome tumor therapeutic resistance and recurrence. This review discusses the tropism of OVs towards tumor cells and their interaction with immune cells, tumor stroma, vasculature, and the metabolic environment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Oncology

OrienX010, an oncolytic virus, in patients with unresectable stage IIIC-IV melanoma: a phase Ib study

ChuanLiang Cui et al.

Summary: The modified oncolytic virus OrienX010 was evaluated in Chinese patients with melanoma, and the results showed that it had antitumor effects in both injected and non-injected lesions with tolerable safety profile. The higher dose was selected as the recommended dose for ongoing trials based on these findings.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

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Article Biochemistry & Molecular Biology

Molecular Mechanisms of Anti-Neoplastic and Immune Stimulatory Properties of Oncolytic Newcastle Disease Virus

Volker Schirrmacher

Summary: This review provides an update on the molecular mechanisms of the avian paramyxovirus, Newcastle Disease Virus (NDV), in its anti-neoplastic and immune stimulatory properties. It highlights the potential of NDV as a unique oncolytic virus that can overcome therapy resistance in human cancer cells.

BIOMEDICINES (2022)

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Article Chemistry, Multidisciplinary

Full encapsulation of oncolytic virus using hybrid erythroctye-liposome membranes for augmented anti-refractory tumor effectiveness

Hanwei Huang et al.

Summary: Intravenous delivery of oncolytic virus (OVs) is promising in cancer treatment, but its wide application has been impeded by fast clearance and severe cytokine release syndrome. Researchers have developed erythrocyte-lipid hybrid membrane vesicles to fully encapsulate OVs, leading to prolonged circulation and enhanced oncolytic efficacy.

NANO TODAY (2022)

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Review Oncology

Immune checkpoint Inhibitor-Induced diarrhea and Colitis: Incidence and Management. A systematic review and Meta-analysis

Dorte Lisbet Nielsen et al.

Summary: ICIs, either alone or in combination with chemotherapy or TKIs, have shown improved cancer outcomes. However, they also carry the risk of immune-related adverse effects, such as diarrhea and colitis. A tailored approach is needed for the management of these adverse effects.

CANCER TREATMENT REVIEWS (2022)

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Review Urology & Nephrology

Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury

Ben Sprangers et al.

Summary: Immune checkpoint inhibitors (ICIs) have had a significant impact on cancer treatment, but their use can lead to immune-related adverse events, including acute kidney injury. This review provides an overview of the symptoms, biochemical markers, and potential underlying mechanisms of ICI-associated acute kidney injury, and proposes a diagnostic and management approach.

NATURE REVIEWS NEPHROLOGY (2022)

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Review Virology

Host factors associated with either VP16 or VP16-induced complex differentially affect HSV-1 lytic infection

Xiuyan Ding et al.

Summary: HSV-1 is a neurotropic human pathogen that can establish lifelong latency in sensory neurons and cause recurrent disease. VP16, a component of HSV-1 virion, interacts with host factors to stimulate gene transcription and affect host immune responses.

REVIEWS IN MEDICAL VIROLOGY (2022)

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Review Immunology

Application of artificial liver in immune-related liver injury induced by immune checkpoint inhibitor: Case reports and review of the literature

Xuewei Li et al.

Summary: The use of immune checkpoint inhibitors (ICIs) can improve survival of patients with malignant tumors, but is also associated with unpredictable immune-related adverse effects (irAEs). This study reports two cases of severe immune-mediated hepatotoxicity (IMH) in patients with metastatic malignant gastrointestinal tumors after ICI therapy. Both cases were successfully treated with immunosuppressive therapy and non-biological artificial liver, resulting in restored liver function and maintained anti-tumor treatment effect.

FRONTIERS IN IMMUNOLOGY (2022)

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Editorial Material Chemistry, Multidisciplinary

Leukocyte-nanomedicine system for targeted delivery and precise theragnostics

Xin Li et al.

Summary: By modifying the binding peptides on nanomedicines, Cruz et al. improved the therapy of venous thrombosis by hitchhiking with specifically activated leukocytes.

CHEM (2022)

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Article Oncology

Fueling immune checkpoint blockade with oncolytic viruses: Current paradigms and challenges ahead

Shu-Jin Li et al.

Summary: The challenge in improving response rates to immune checkpoint inhibitors is to convert immune cold tumors into hot tumors. Oncolytic viruses are considered promising therapeutic platforms that can activate the immune system. However, their usage faces limitations and challenges.

CANCER LETTERS (2022)

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Review Oncology

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data

Ashton A. Connor et al.

Summary: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest epithelial malignancies, with increasing research over several decades leading to a better understanding of its carcinogenesis and significant progress in genomics and transcriptomics. The inclusion of PDAC data in international pan-cancer analyses has provided further insights, and the study of PDAC evolution and heterogeneity has led to the proposal of an evolutionary model based on genomics studies of human PDAC.

NATURE REVIEWS CANCER (2022)

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Article Oncology

Oncolytic virotherapy: Challenges and solutions

Nasser Hashemi Goradel et al.

Summary: Oncolytic viruses have been explored as cancer therapies since the 19th century, with the observation that they can selectively target cancer cells. Despite progress, challenges such as immune responses and tumor microenvironment issues remain hurdles to overcome.

CURRENT PROBLEMS IN CANCER (2021)

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Review Biotechnology & Applied Microbiology

Combining oncolytic virus with FDA approved pharmacological agents for cancer therapy

Wei Zhang et al.

Summary: Oncolytic viruses (OVs) have been engineered to selectively replicate in cancer cells and interact with cellular processes, augmenting the anti-neoplastic effects and inducing potent immune responses. Combining OVs with FDA approved anti-cancer agents and immunotherapies shows potential for synergistic therapeutic effects, but further understanding of virus-host interactions is necessary for meaningful advances in this field.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Biochemistry & Molecular Biology

Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB-IVM1a melanoma: a randomized, open-label, phase 2 trial

R. Dummer et al.

Summary: The study found that intralesional injection of an oncolytic virus prior to surgery is clinically beneficial for patients with locally advanced, resectable melanoma, leading to improved recurrence-free survival.

NATURE MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Oncolytic adenovirus with hyaluronidase activity that evades neutralizing antibodies: VCN-11

Ana Mato-Berciano et al.

Summary: VCN-11 is a novel oncolytic adenovirus that can self-coat with albumin to evade neutralizing antibodies, showing low toxicity and high cytotoxicity specifically towards tumor cells. The virus disrupts tumor matrix and displays antitumor effects, making it a safe and promising candidate for clinical trials.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Biotechnology & Applied Microbiology

Clinical CAR-T Cell and Oncolytic Virotherapy for Cancer Treatment

Norihiro Watanabe et al.

Summary: Immunotherapy using CAR-T cells and OVs has shown promise in cancer treatment, but the benefits as single-agent therapies are still limited to a subset of patients. Combinations of different targeted therapies may be needed to achieve efficient, durable responses against heterogeneous tumors and the microenvironment.

MOLECULAR THERAPY (2021)

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Editorial Material Biotechnology & Applied Microbiology

Oncolytic Viruses for Systemic Administration: Engineering a Whole Different Animal

Svetlana Atasheva et al.

MOLECULAR THERAPY (2021)

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Article Chemistry, Multidisciplinary

Multi-Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors

Xin Li et al.

Summary: In this study, intelligent cationic NGs with tunable responsiveness, versatility, and biodegradation are developed for precision medicine applications. By utilizing modular design and engineered strategy, NGs with different responsiveness and functionalities are prepared, including hybrid NGs with high photothermal conversion efficiency and drug release properties combined with photothermal-chemotherapy.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Pharmacology & Pharmacy

Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies

Mackenzie J. Dodge et al.

Summary: Human adenoviruses are common pathogens causing respiratory, ocular, and gastrointestinal illnesses, with severe risks for children and immunocompromised individuals. There are currently no approved antiviral therapies specific to HAdV, highlighting the urgent need for effective agents to treat life-threatening infections. This review focuses on recent developments in search of potential therapeutic agents targeting post-entry stages of the virus replicative cycle.

ANTIVIRAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Delivery routes matter: Safety and efficacy of intratumoral immunotherapy

Emily De Lombaerde et al.

Summary: Direct intratumoral injection allows for local immune activation, leading to decreased systemic toxicity, improved efficacy, and abscopal effects. The approval of the first intratumoral oncolytic virotherapy, talimogene laherparepvec (T-VEC), has sparked interest in studying other immunotherapeutic approaches.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Review Oncology

Role of Isolated Limb Perfusion in the Era of Targeted Therapies and Immunotherapy in Melanoma. A Systematic Review of The Literature

Lourdes Sevilla-Ortega et al.

Summary: Isolated limb perfusion (ILP) remains as an effective and safe treatment for selected patients with advanced melanoma, contributing to improving their quality of life. Ongoing clinical trials combining ILP with systemic therapies will provide further insights into the potential synergistic effects of these strategies.

CANCERS (2021)

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Review Oncology

Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy

Masmudur M. Rahman et al.

Summary: Oncolytic viruses (OVs) are a novel cancer treatment modality that selectively target and kill cancer cells while sparing normal ones. Engineered OVs show great potential in clinical trials, but combination therapies with other treatments may further improve their efficacy.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Giving Oncolytic Viruses a Free Ride: Carrier Cells for Oncolytic Virotherapy

Alberto Reale et al.

Summary: Oncolytic viruses are a new class of therapeutic agents with multiple mechanisms of action, including direct cancer cell-killing, immunotherapy, and gene therapy. Developing an effective delivery system, such as using carrier cells, is crucial to accelerate the clinical advancement of oncolytic viruses. Mesenchymal stem cells have been heavily investigated as carrier cells due to their inherent tumor tropism.

PHARMACEUTICS (2021)

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Review Oncology

Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies

Johannes P. W. Heidbuechel et al.

Summary: Bispecific T cell engagers (BiTEs) and oncolytic viruses (OVs) are emerging cancer immunotherapies that redirect T cells to tumor surface antigens and selectively infect malignant cells to mediate tumor vaccination effects, respectively. These two approaches can synergize with each other and with other immunotherapies, such as CAR T cells and immune checkpoint inhibitors, to enhance anti-tumor effects.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Review Cell Biology

Oncolytic Virotherapy: From Bench to Bedside

Ludi Yang et al.

Summary: Oncolytic viruses, either natural or genetically engineered, can replicate in tumor cells and inhibit tumor growth, making them an effective anticancer strategy. Their multifunctional characteristics suggest promising application prospects in cancer therapeutics.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Immunology

Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control

Dafne C. A. Quixabeira et al.

Summary: Developing variants of IL-2 cytokine shows promise in treating tumors by preferentially binding to effector anti-tumor lymphocytes and inhibiting T regulatory cells. The adenovirus Ad5/3-E2F-d24-vIL2 demonstrates efficient anti-tumor response in hamsters with pancreatic tumors, with potential for clinical trials in human solid tumors by counteracting immunosuppression and enhancing lymphocyte-mediated anti-tumor response.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB-IVM1c melanoma

Josep Malvehy et al.

Summary: This study demonstrates that T-VEC induces systemic immune activity and modifies the tumor microenvironment, potentially enhancing the efficacy of combination immunotherapy with other agents.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Oncology

Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma

Georgia M. Beasley et al.

Summary: In a phase I trial of intratumoral PVSRIPO in patients with unresectable melanoma, the treatment was well tolerated with promising antitumor activity, showing no serious adverse events reported and achieving an objective response rate of 33%, with some patients experiencing complete response in both injected and uninjected lesions.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy

Dong Ho Shin et al.

Summary: Cancer virotherapy is a paradigm-shifting treatment approach that relies on virus-mediated oncolysis and anti-tumor immune responses. However, the antiviral immunity of patients may limit the potential of this therapy. Future strategies should focus on maximizing the immunotherapeutic potential of oncolytic viruses to improve clinical outcomes.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology

Talimogene Laherparepvec (T-VEC): An Intralesional Cancer Immunotherapy for Advanced Melanoma

Pier Francesco Ferrucci et al.

Summary: Talimogene laherparepvec (T-VEC) is an oncolytic viral immunotherapy approved for the treatment of melanoma, aiming to trigger immune responses locally and potentially synergize with immune checkpoint inhibitors.

CANCERS (2021)

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Article Oncology

Clinical Responses of Oncolytic Coxsackievirus A21 (V937) in Patients With Unresectable Melanoma

Robert H. I. Andtbacka et al.

Summary: The study evaluated the activity of intratumoral Coxsackievirus A21 (V937) in 57 patients with unresectable melanoma. Results showed that V937 was well tolerated and showed promising efficacy, warranting further investigation. Studies on combination approaches with V937 and immune checkpoint inhibitors are ongoing.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Oncology

Neural stem cell delivery of an oncolytic adenovirus in newly diagnosed malignant glioma: a first-in-human, phase 1, dose-escalation trial

Jawad Fares et al.

Summary: The study investigated the safety and activity of NSC-CRAd-S-pk7, an engineered oncolytic adenovirus delivered by neural stem cells (NSCs), in patients with newly diagnosed high-grade glioma. The treatment was found to be feasible and safe, supporting further investigation in a phase 2/3 clinical trial.

LANCET ONCOLOGY (2021)

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Review Virology

Oncolytic Viruses for Malignant Glioma: On the Verge of Success?

Yogesh R. Suryawanshi et al.

Summary: Glioblastoma is a challenging tumor type to treat with conventional therapy, but immunotherapeutic agents have shown limited success and further optimization is needed. Some oncolytic viruses have demonstrated the ability to infect tumors in malignant glioma patients, but hurdles like the blood-brain barrier and tumor heterogeneity can reduce their efficacy. Strategies are being developed to optimize oncolytic virotherapy outcomes.

VIRUSES-BASEL (2021)

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Article Pharmacology & Pharmacy

Polymer Coated Oncolytic Adenovirus to Selectively Target Hepatocellular Carcinoma Cells

Mariangela Garofalo et al.

Summary: This study explored the use of polymer-coated oncolytic viruses for the treatment of hepatocellular carcinoma, showing higher therapeutic efficacy in cells expressing high levels of ASGPR. The polymer coating altered the viral properties, enhancing infectivity and immunogenic cell death compared to naked viruses.

PHARMACEUTICS (2021)

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Review Chemistry, Analytical

Selective-sampling Raman imaging techniques for ex vivo assessment of surgical margins in cancer surgery

Maria Giovanna Lizio et al.

Summary: One of the main challenges in cancer surgery is to ensure complete excision of the tumor while sparing healthy tissue. Histopathology is often impractical for intra-operative use due to time constraints, but Raman micro-spectroscopy offers a potential solution. Selective-sampling Raman imaging reduces acquisition time and has promising results in clinical integration for assessing surgical margins accurately and quickly.

ANALYST (2021)

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Article Medicine, Research & Experimental

Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation

Lingjuan Chen et al.

Summary: Armed with IL-23 variants, oncolytic vaccinia viruses can enhance anti-tumor immune responses, transforming the tumor microenvironment to be more favorable for anti-tumor effects.

THERANOSTICS (2021)

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Article Oncology

Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity

Joao Manuel Santos et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Cell Biology

Oncolytic Virus Encoding a Master Pro-Inflammatory Cytokine Interleukin 12 in Cancer Immunotherapy

Hong-My Nguyen et al.

CELLS (2020)

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Editorial Material Biochemistry & Molecular Biology

SnapShot: Natural Killer Cells

Adeline Crinier et al.

CELL (2020)

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Review Pharmacology & Pharmacy

Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses

Agata Hadrys et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Oncology

Elucidation of Pelareorep Pharmacodynamics in A Phase I Trial in Patients with KRAS-Mutated Colorectal Cancer

Sanjay Goel et al.

MOLECULAR CANCER THERAPEUTICS (2020)

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Article Biotechnology & Applied Microbiology

Safety, Tumor Reduction, and Clinical Impact of Zika Virus Injection in Dogs with Advanced-Stage Brain Tumors

Carolini Kaid et al.

MOLECULAR THERAPY (2020)

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Review Biochemistry & Molecular Biology

The two-faces of NK cells in oncolytic virotherapy

M. Marotel et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

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Review Biochemistry & Molecular Biology

Kinase inhibitors with viral oncolysis: Unmasking pharmacoviral approaches for cancer therapy

Victoria Heather Gilchrist et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

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Article Medicine, Research & Experimental

Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

E. Antonio Chiocca et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

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Article Oncology

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)

Sean M. O'Cathail et al.

RADIATION ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

Oncolytic Viruses and Immune Checkpoint Inhibitors: Preclinical Developments to Clinical Trials

June Kyu Hwang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Pharmacology & Pharmacy

Delivery systems for enhancing oncolytic adenoviruses efficacy

Yu-Cheng Zhou et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Clinical Neurology

Endovascular Selective Intra-Arterial Infusion of Mesenchymal Stem Cells Loaded With Delta-24 in a Canine Model

Visish M. Srinivasan et al.

NEUROSURGERY (2020)

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Review Biochemistry & Molecular Biology

Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy

Bin Zhang et al.

MOLECULAR CANCER (2020)

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Review Biochemistry & Molecular Biology

Design and Engineering of Deimmunized Vaccinia Viral Vectors

Kevin Song et al.

BIOMEDICINES (2020)

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Review Biochemistry & Molecular Biology

Cancer Vaccines and Oncolytic Viruses Exert Profoundly Lower Side Effects in Cancer Patients than Other Systemic Therapies: A Comparative Analysis

Volker Schirrmacher

BIOMEDICINES (2020)

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Article Medicine, Research & Experimental

Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: Boosting the efficacy of intravenously administered therapeutic adenoviruses

Pau Brugada-Vila et al.

THERANOSTICS (2020)

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Article Oncology

PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma

Henry G. Smith et al.

CLINICAL CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model

Francesco Alessandrini et al.

ONCOGENE (2019)

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Review Oncology

Updates to the antitumor mechanism of oncolytic virus

Yang Bai et al.

THORACIC CANCER (2019)

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Oncolytic Virus-Based Cytokine Expression to Improve Immune Activity in Brain and Solid Tumors

Taylor M. Pearl et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

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Enhanced Safety and Efficacy of Oncolytic VSV Therapy by Combination with T Cell Receptor Transgenic T Cells as Carriers

Michael Karl Melzer et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

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Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application

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Phase I Trial of an ICAM-1-Targeted Immunotherapeutic-Coxsackievirus A21 (CVA21) as an Oncolytic Agent Against Non Muscle-Invasive Bladder Cancer

Nicola E. Annels et al.

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Claudia Hill et al.

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Systemic administration of human mesenchymal stromal cells infected with polymer-coated oncolytic adenovirus induces efficient pancreatic tumor homing and infiltration

Youjin Na et al.

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Exosomes Carry microRNAs into Neighboring Cells to Promote Diffusive Infection of Newcastle Disease Virus

Changluan Zhou et al.

VIRUSES-BASEL (2019)

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Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III- IV melanoma

Robert H. Andtbacka et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment

Monica Marzagalli et al.

SEMINARS IN CANCER BIOLOGY (2019)

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Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study

Antonio Marchini et al.

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Biodistribution, shedding, and transmissibility of the oncolytic virus talimogene laherparepvec in patients with melanoma

Robert H. I. Andtbacka et al.

EBIOMEDICINE (2019)

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Article Chemistry, Multidisciplinary

MnCaCs-Biomineralized Oncolytic Virus for Bimodal Imaging-Guided and Synergistically Enhanced Anticancer Therapy

Li-Li Huang et al.

NANO LETTERS (2019)

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Review Cell Biology

Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches

Nasser Hashemi Goradel et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Multidisciplinary Sciences

Artificially cloaked viral nanovaccine for cancer immunotherapy

Manlio Fusciello et al.

NATURE COMMUNICATIONS (2019)

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Review Oncology

Oncolytic Viruses for Cancer Therapy: Barriers and Recent Advances

Meijun Zheng et al.

MOLECULAR THERAPY-ONCOLYTICS (2019)

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Article Oncology

A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer

Yoshiki Hirooka et al.

BMC CANCER (2018)

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Article Oncology

Zika Virus Selectively Kills Aggressive Human Embryonal CNS Tumor Cells In Vitro and In Vivo

Carolini Kaid et al.

CANCER RESEARCH (2018)

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Review Oncology

Oncorine, the World First Oncolytic Virus Medicine and its Update in China

Min Liang

CURRENT CANCER DRUG TARGETS (2018)

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Review Immunology

Oncolytic viruses and immunity

Shyambabu Chaurasiya et al.

CURRENT OPINION IN IMMUNOLOGY (2018)

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Article Pharmacology & Pharmacy

Design of PEI-conjugated bio-reducible polymer for efficient gene delivery

Joung-Pyo Nam et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Article Oncology

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma

Frederick F. Lang et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Oncology

Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB-IVM1c melanoma

Jason Chesney et al.

MELANOMA RESEARCH (2018)

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Article Biotechnology & Applied Microbiology

Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade

Stacy J. Kowalsky et al.

MOLECULAR THERAPY (2018)

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Article Medicine, General & Internal

Recurrent Glioblastoma Treated with Recombinant Poliovirus

Annick Desjardins et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Cell Biology

Neoadjuvant oncolytic virotherapy before surgery sensitizes triple- negative breast cancer to immune checkpoint therapy

Marie-Claude Bourgeois-Daigneault et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Article Cell Biology

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

Adel Samson et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

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Review Immunology

Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies

Shashi Gujar et al.

TRENDS IN IMMUNOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Talimogene laherparepvec: First in class oncolytic virotherapy

Robert M. Conry et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

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Review Immunology

Tolerogenic Dendritic Cells as a Promising Antigen-Specific Therapy in the Treatment of Multiple Sclerosis and Neuromyelitis Optica From Preclinical to Clinical Trials

Georgina Florez-Grau et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Oncolytic Viral Therapy and the Immune System: A Double-Edged Sword Against Cancer

Giulia Marelli et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

Phosphatidylserine-liposomes Promote Tolerogenic Features on Dendritic cells in human Type 1 Diabetes by apoptotic Mimicry

Silvia Rodriguez-Fernandez et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines

Edmund K. Moon et al.

ONCOIMMUNOLOGY (2018)

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Article Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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Review Immunology

Oncolytic Viruses Partner With T-Cell Therapy for Solid Tumor Treatment

Amanda Rosewell Shaw et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge

Sonia Guedan et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Oncology

Deciphering the Role of Regulatory CD4 T Cells in Oral and Oropharyngeal Cancer: A Systematic Review

Caoimhin O' Higgins et al.

FRONTIERS IN ONCOLOGY (2018)

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Review Oncology

Oncolytic viruses as engineering platforms for combination immunotherapy

Kwame Twumasi-Boateng et al.

NATURE REVIEWS CANCER (2018)

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Article Medicine, Research & Experimental

Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses

Keisuke Watanabe et al.

JCI INSIGHT (2018)

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Review Cell Biology

Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma

Chang-Yu Chen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

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Article Oncology

Amplification of Oncolytic Vaccinia Virus Widespread Tumor Cell Killing by Sunitinib through Multiple Mechanisms

Minah Kim et al.

CANCER RESEARCH (2018)

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Review Immunology

Integrating oncolytic viruses in combination cancer immunotherapy

Praveen K. Bommareddy et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Oncology

Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy

Jun Ren et al.

ONCOIMMUNOLOGY (2017)

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Article Immunology

Virus-host interactions under hypoxia

Niki Vassilaki et al.

MICROBES AND INFECTION (2017)

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Review Biotechnology & Applied Microbiology

Oncolytic Virotherapy: A Contest between Apples and Oranges

Stephen J. Russell et al.

MOLECULAR THERAPY (2017)

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Article Multidisciplinary Sciences

Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine

Johanna Marsian et al.

NATURE COMMUNICATIONS (2017)

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Review Oncology

VSV based virotherapy in ovarian cancer: the past, the present and ...future?

Beata Urszula Orzechowska et al.

JOURNAL OF CANCER (2017)

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Review Oncology

Oncolytic Viruses in Cancer Treatment A Review

Sean E. Lawler et al.

JAMA ONCOLOGY (2017)

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Article Engineering, Biomedical

A hydrogel matrix prolongs persistence and promotes specific localization of an oncolytic adenovirus in a tumor by restricting nonspecific shedding and an antiviral immune response

Bo-Kyeong Jung et al.

BIOMATERIALS (2017)

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Article Engineering, Biomedical

Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus

Dayananda Kasala et al.

BIOMATERIALS (2017)

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Article Oncology

Phase I Trial of Intravenous Oncolytic Vaccinia Virus (GL-ONC1) with Cisplatin and Radiotherapy in Patients with Locoregionally Advanced Head and Neck Carcinoma

Loren K. Mell et al.

CLINICAL CANCER RESEARCH (2017)

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Article Oncology

Armed Oncolytic Adenovirus-Expressing PD-L1 Mini-Body Enhances Antitumor Effects of Chimeric Antigen Receptor T Cells in Solid Tumors

Kiyonori Tanoue et al.

CANCER RESEARCH (2017)

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Article Oncology

Oncolytic Virus-Mediated Targeting of PGE2 in the Tumor Alters the Immune Status and Sensitizes Established and Resistant Tumors to Immunotherapy

Weizhou Hou et al.

CANCER CELL (2016)

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Review Cell & Tissue Engineering

Mesenchymal stromal cells and immunomodulation: A gathering of regulatory immune cells

Mehdi Najar et al.

CYTOTHERAPY (2016)

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Review Pharmacology & Pharmacy

Redirecting adenovirus tropism by genetic, chemical, and mechanical modification of the adenovirus surface for cancer gene therapy

A-Rum Yoon et al.

EXPERT OPINION ON DRUG DELIVERY (2016)

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Article Oncology

Isolated limb perfusion with biochemotherapy and oncolytic virotherapy combines with radiotherapy and surgery to overcome treatment resistance in an animal model of extremity soft tissue sarcoma

Michelle J. Wilkinson et al.

INTERNATIONAL JOURNAL OF CANCER (2016)

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Article Oncology

Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma

Igor Puzanov et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

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Article Chemistry, Multidisciplinary

Albumin-binding adenoviruses circumvent pre-existing neutralizing antibodies upon systemic delivery

Luis Alfonso Rojas et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Genetics & Heredity

Oncolytic viruses-immunotherapeutics on the rise

Brian A. Keller et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2016)

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Review Urology & Nephrology

Oncolytic virotherapy for urological cancers

Zahid Delwar et al.

NATURE REVIEWS UROLOGY (2016)

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Article Cell & Tissue Engineering

Intranasal Oncolytic Virotherapy with CXCR4-Enhanced Stem Cells Extends Survival in Mouse Model of Glioma

Mahua Dey et al.

STEM CELL REPORTS (2016)

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Article Oncology

Phase I study with ONCOS-102 for the treatment of solid tumors - an evaluation of clinical response and exploratory analyses of immune markers

Tuuli Ranki et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2016)

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Review Biochemistry & Molecular Biology

From Benchtop to Bedside: A Review of Oncolytic Virotherapy

Audrey H. Choi et al.

BIOMEDICINES (2016)

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Article Biotechnology & Applied Microbiology

Environmental Surveillance of Poliovirus in Sewage Water around the Introduction Period for Inactivated Polio Vaccine in Japan

Tomofumi Nakamura et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

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Review Pharmacology & Pharmacy

Intranasal delivery: circumventing the iron curtain to treat neurological disorders

Yongjun Jiang et al.

EXPERT OPINION ON DRUG DELIVERY (2015)

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Article Oncology

Engineered adenoviruses combine enhanced oncolysis with improved virus production by mesenchymal stromal carrier cells

Katharina Hammer et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Article Oncology

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

Robert H. I. Andtbacka et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Biotechnology & Applied Microbiology

Viral Infection of Tumors Overcomes Resistance to PD-1-immunotherapy by Broadening Neoantigenome-directed T-cell Responses

Norman Woller et al.

MOLECULAR THERAPY (2015)

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Review Biotechnology & Applied Microbiology

Oncolytic viruses: a new class of immunotherapy drugs

Howard L. Kaufman et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

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Article Virology

Induction of apoptosis in pancreatic cancer cells by vesicular stomatitis virus

Sebastien A. Felt et al.

VIROLOGY (2015)

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Review Medicine, Research & Experimental

Current Approaches for Improving Intratumoral Accumulation and Distribution of Nanomedicines

Mikhail O. Durymanov et al.

THERANOSTICS (2015)

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Article Medicine, Research & Experimental

Characterization of Magnetic Viral Complexes for Targeted Delivery in Oncology

Isabella Almstaetter et al.

THERANOSTICS (2015)

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Article Virology

Cytotoxic and immunogenic mechanisms of recombinant oncolytic poliovirus

Michael C. Brown et al.

CURRENT OPINION IN VIROLOGY (2015)

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Article Oncology

In-transit Melanoma Metastases: Incidence, Prognosis, and the Role of Lymphadenectomy

Rebecca L. Read et al.

ANNALS OF SURGICAL ONCOLOGY (2015)

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Article Oncology

Isolated limb perfusion with melphalan, tumour necrosis factor-alpha and oncolytic vaccinia virus improves tumour targeting and prolongs survival in a rat model of advanced extremity sarcoma

Tim D. Pencavel et al.

INTERNATIONAL JOURNAL OF CANCER (2015)

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Review Oncology

Oncolytic Viruses: Exploiting Cancer's Deal with the Devil

Larissa A. Pikor et al.

TRENDS IN CANCER (2015)

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Article Medicine, General & Internal

Selective intra-arterial infusion of rAd-p53 with chemotherapy for advanced oral cancer: a randomized clinical trial

Yi Li et al.

BMC MEDICINE (2014)

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Article Biochemistry & Molecular Biology

CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain

Shengke Hou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Review Chemistry, Multidisciplinary

A clinical update of using albumin as a drug vehicle - A commentary

Felix Kratz

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Virology

Potent Neutralization of Vaccinia Virus by Divergent Murine Antibodies Targeting a Common Site of Vulnerability in L1 Protein

Thomas Kaever et al.

JOURNAL OF VIROLOGY (2014)

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Article Multidisciplinary Sciences

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Paul C. Tumeh et al.

NATURE (2014)

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Article Biotechnology & Applied Microbiology

Mesenchymal stem cells: immune evasive, not immune privileged

James A. Ankrum et al.

NATURE BIOTECHNOLOGY (2014)

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Review Microbiology

New viruses for cancer therapy: meeting clinical needs

Tanner S. Miest et al.

NATURE REVIEWS MICROBIOLOGY (2014)

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Review Immunology

Armed therapeutic viruses - a disruptive therapy on the horizon of cancer immunotherapy

Maxine Bauzon et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Oncology

Consensus guidelines for the detection of immunogenic cell death

Oliver Kepp et al.

ONCOIMMUNOLOGY (2014)

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Review Oncology

High dose interleukin-2 (Aldesleukin) - expert consensus on best management practices-2014

Janice P. Dutcher et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2014)

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Article Biotechnology & Applied Microbiology

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

Ilkka Liikanen et al.

MOLECULAR THERAPY (2013)

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Article Biotechnology & Applied Microbiology

Multifaceted Therapeutic Targeting of Ovarian Peritoneal Carcinomatosis Through Virus-induced Immunomodulation

Shashi Gujar et al.

MOLECULAR THERAPY (2013)

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Article Biochemistry & Molecular Biology

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

Jeong Heo et al.

NATURE MEDICINE (2013)

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Article Oncology

Intraductal Delivery of Adenoviruses Targets Pancreatic Tumors in Transgenic Ela-myc Mice and Orthotopic Xenografts

Anabel Jose et al.

ONCOTARGET (2013)

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Article Cell & Tissue Engineering

Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells

Andreia Ribeiro et al.

STEM CELL RESEARCH & THERAPY (2013)

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Article Oncology

Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties That Is Active against Lung Adenocarcinoma

Shohei Miyamoto et al.

CANCER RESEARCH (2012)

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Review Biochemistry & Molecular Biology

Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells

Jian Chen et al.

CELL (2012)

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Article Oncology

Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies

Eleni M. Karapanagiotou et al.

CLINICAL CANCER RESEARCH (2012)

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Article Virology

Adenovirus Serotype 5 Neutralizing Antibodies Target both Hexon and Fiber following Vaccination and Natural Infection

Ritu R. Bradley et al.

JOURNAL OF VIROLOGY (2012)

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Article Pharmacology & Pharmacy

Clinical trials involving the oncolytic virus, reovirus: ready for prime time?

Allison J. Black et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2012)

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Article Biotechnology & Applied Microbiology

Carrier cell-based delivery of replication-competent HSV-1 mutants enhances antitumor effect for ovarian cancer

S. Fujiwara et al.

CANCER GENE THERAPY (2011)

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Article Cell Biology

Acetylation is indispensable for p53 antiviral activity

Cesar Munoz-Fontela et al.

CELL CYCLE (2011)

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Review Oncology

Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?

Jay D. Naik et al.

CLINICAL CANCER RESEARCH (2011)

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Review Biotechnology & Applied Microbiology

Strategies to Enhance Viral Penetration of Solid Tumors

Elspeth Smith et al.

HUMAN GENE THERAPY (2011)

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Article Chemistry, Multidisciplinary

Viral genome DNA/lipoplexes elicit in situ oncolytic viral replication and potent antitumor efficacy via systemic delivery

Oh-Joon Kwon et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Orthopedics

Oncolytic Vesicular Stomatitis Virus Administered by Isolated Limb Perfusion Suppresses Osteosarcoma Growth

Tadahiko Kubo et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2011)

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Article Biotechnology & Applied Microbiology

Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy

Jeong Heo et al.

MOLECULAR THERAPY (2011)

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Article Biotechnology & Applied Microbiology

A Mechanistic Proof-of-concept Clinical Trial With JX-594, a Targeted Multi-mechanistic Oncolytic Poxvirus, in Patients With Metastatic Melanoma

Tae-Ho Hwang et al.

MOLECULAR THERAPY (2011)

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Review Virology

Induction and function of virus-specific CD4+T cell responses

Jason K. Whitmire

VIROLOGY (2011)

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Article Biotechnology & Applied Microbiology

Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study

J. Garcia-Castro et al.

CANCER GENE THERAPY (2010)

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Article Oncology

Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma

Reiko Nakai et al.

CANCER SCIENCE (2010)

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Article Oncology

Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers

Kevin J. Harrington et al.

CLINICAL CANCER RESEARCH (2010)

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Article Oncology

Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck

Kevin J. Harrington et al.

CLINICAL CANCER RESEARCH (2010)

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Review Biochemistry & Molecular Biology

Impact of tumor microenvironment on oncolytic viral therapy

Jeffrey Wojton et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2010)

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Article Oncology

Reovirus Virotherapy Overrides Tumor Antigen Presentation Evasion and Promotes Protective Antitumor Immunity

Shashi A. Gujar et al.

MOLECULAR CANCER THERAPEUTICS (2010)

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Article Biotechnology & Applied Microbiology

A Phase I Study of Telomerase-specific Replication Competent Oncolytic Adenovirus (Telomelysin) for Various Solid Tumors

John Nemunaitis et al.

MOLECULAR THERAPY (2010)

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Article Biotechnology & Applied Microbiology

Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

Sonia Guedan et al.

MOLECULAR THERAPY (2010)

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Review Oncology

Delivering nanomedicine to solid tumors

Rakesh K. Jain et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

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Article Biochemistry & Molecular Biology

A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy

Y. Watanabe et al.

ONCOGENE (2010)

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Article Multidisciplinary Sciences

Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks

Hongrong Liu et al.

SCIENCE (2010)

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Article Hematology

Tumor-associated macrophages infiltrate plasmacytomas and can serve as cell carriers for oncolytic measles virotherapy of disseminated myeloma

Kah-Whye Peng et al.

AMERICAN JOURNAL OF HEMATOLOGY (2009)

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Article Oncology

Human Bone Marrow-Derived Mesenchymal Stem Cells for Intravascular Delivery of Oncolytic Adenovirus Delta 24-RGD to Human Gliomas

Raymund L. Yong et al.

CANCER RESEARCH (2009)

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Article Biochemistry & Molecular Biology

A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients

J-L Li et al.

GENE THERAPY (2009)

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Article Multidisciplinary Sciences

Activation of NF-kB Pathway by Virus Infection Requires Rb Expression

Maria A. Garcia et al.

PLOS ONE (2009)

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Article Oncology

Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation

Fabian Benencia et al.

CANCER BIOLOGY & THERAPY (2008)

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Article Oncology

Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity

Robin J. Prestwich et al.

CLINICAL CANCER RESEARCH (2008)

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Article Gastroenterology & Hepatology

Synergistic Antitumor Effects of Transarterial Viroembolization for Multifocal Hepatocellular Carcinoma in Rats

Jennifer Altomonte et al.

HEPATOLOGY (2008)

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Article Biotechnology & Applied Microbiology

Significant antitumor activity of oncolytic adenovirus expressing human interferon-β for hepatocellular carcinoma

Ling Feng He et al.

JOURNAL OF GENE MEDICINE (2008)

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Article Immunology

Reovirus activates human dendritic cells to promote innate antitumor immunity

Fiona Errington et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Oncology

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

Byeong-Ho Park et al.

LANCET ONCOLOGY (2008)

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Article Gastroenterology & Hepatology

Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus

Narayan Dharel et al.

HEPATOLOGY (2008)

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Article Oncology

An optimized clinical regimen for the oncolytic virus PV701

Sebastien J. Hotte et al.

CLINICAL CANCER RESEARCH (2007)

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Review Biotechnology & Applied Microbiology

History of oncolytic viruses: Genesis to genetic engineering

Elizabeth Kelly et al.

MOLECULAR THERAPY (2007)

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Article Biotechnology & Applied Microbiology

A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer

Eric J. Small et al.

MOLECULAR THERAPY (2006)

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Article Virology

Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76

MK Merrill et al.

JOURNAL OF VIROLOGY (2006)

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Article Oncology

Targeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus

H Ochiai et al.

CLINICAL CANCER RESEARCH (2006)

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Article Biotechnology & Applied Microbiology

Oncolytic adenovirus CG7870 in combination with radiation demonstrates synergistic enhancements of antitumor efficacy without loss of specificity

J Dilley et al.

CANCER GENE THERAPY (2005)

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