Oncolytic Virus-Driven Biotherapies from Bench to Bedside

With advances in cancer biology and an ever-deepening understanding of molecular virology, oncolytic virus (OV)-driven therapies have developed rapidly and become a promising alternative to traditional cancer therapies. In recent years, satisfactory results for oncolytic virus therapy (OVT) are achieved at both the cellular and organismal levels, and efforts are being increasingly directed toward clinical trials. Unfortunately, OVT remains ineffective in these trials, especially when performed using only a single OV reagent. In contrast, integrated approaches, such as using immunotherapy, chemotherapy, or radiotherapy, alongside OVT have demonstrated considerable efficacy. The challenges of OVT in clinical efficacy include the restricted scope of intratumoral injections and poor targeting of intravenous administration. Further optimization of OVT delivery is needed before OVs become a viable therapy for tumor treatment. In this review, the development process and antitumor mechanisms of OVs are introduced. The advances in OVT delivery routes to provide perspectives and directions for the improvement of OVT delivery are highlighted. This review also discusses the advantages and limitations of OVT monotherapy and combination therapy through the lens of recent clinical trials and aims to chart a course toward safer and more effective OVT strategies.

Automated summary

With advancements in cancer biology and molecular virology, oncolytic virus-driven therapies have emerged as a promising alternative to traditional cancer treatments. However, current clinical trials have shown limited efficacy when using a single oncolytic virus. Integrated approaches combining immunotherapy, chemotherapy, or radiotherapy with oncolytic virus therapy have shown considerable effectiveness. Challenges in oncolytic virus therapy include restricted delivery and poor targeting. Further optimization of delivery methods is needed before oncolytic viruses can become a viable tumor treatment option.