Recent progress of membrane technology for chiral separation: A comprehensive review

More than half of the world's medicines are chiral compounds, and each enantiomer exhibits distinct biological activities. Therefore, the development of efficient enantiomer separation methods is of great importance for human health and safety. However, chiral separation is challenging and complex due to the remarkably identical physical and chemical properties of the two enantiomers. Currently, membrane separation technique has been widely applied in chiral separation because of its advantages of simplicity and efficiency, low energy con-sumption, easy scale-up, and continuous production. Therefore, this paper systematically presents the current research progress of chiral separation membranes in the past decade from the chiral mechanism, summarizes the application of simulation calculation in chiral separation membranes, and emphasizes the importance of enan-tiomeric desorption. Finally, we analyze the challenges and prospects of chiral membranes, and hope to promote the development of chiral membrane technology.

Automated summary

More than half of the world's medicines are chiral compounds, and efficient enantiomer separation methods are crucial for human health and safety. Chiral separation is challenging due to the similarities between enantiomers. Membrane separation technique has been widely used for chiral separation due to its simplicity, efficiency, low energy consumption, scalability, and continuous production.