Optimizing cord management for each preterm baby- Challenges of collating individual participant data and recommendations for future collaborative research

Article Obstetrics & Gynecology

Umbilical Cord Milking in Extremely Preterm Infants: A Randomized Controlled Trial Comparing Cord Milking with Immediate Cord Clamping

Justin B. Josephsen et al.

Summary: In this study comparing umbilical cord milking (UCM) with immediate cord clamping (ICC) in extremely preterm infants, no differences were found in initial hemoglobin or number of blood transfusions between the two groups.

AMERICAN JOURNAL OF PERINATOLOGY (2022)

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Article Obstetrics & Gynecology

Effect of Umbilical Cord Milking on Maternal and Neonatal Outcomes in a Tertiary Care Hospital in South India: A Randomized Control Trial

Anu Anna George et al.

Summary: The study demonstrates that umbilical cord milking significantly increases the levels of hemoglobin and hematocrit in newborns, thus reducing the proportion of anemic infants.

JOURNAL OF OBSTETRICS AND GYNECOLOGY OF INDIA (2022)

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Article Pediatrics

Effects of Umbilical Cord Management Strategies on Stem Cell Transfusion, Delivery Room Adaptation, and Cerebral Oxygenation in Term and Late Preterm Infants

Emel Okulu et al.

Summary: This study found that placental transfusion methods, such as delayed cord clamping and umbilical cord milking, provide more stem cell transfer and better cerebral oxygenation in the early minutes of life in newborns. Immediate cord clamping results in higher residual blood volume and loss of various progenitor cells to the placenta. These cord management methods can serve as a therapeutic source for neonatal diseases.

FRONTIERS IN PEDIATRICS (2022)

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Article Medicine, General & Internal

Physiologically based cord clamping for infants=32+0 weeks gestation: A randomised clinical trial and reference percentiles for heart rate and oxygen saturation for infants=35+0 weeks gestation

Shiraz Badurdeen et al.

Summary: This study compared the effects of PBCC and ECC on newborn heart rate, showing no significant difference in maintaining heart rate between the two. PBCC did not provide additional benefits for newborns receiving brief, effective resuscitation, but may have other important advantages in maternal-infant bonding and iron stores.

PLOS MEDICINE (2022)

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Article Multidisciplinary Sciences

Development of a checklist of standard items for processing individual participant data from randomised trials for meta-analyses: Protocol for a modified e-Delphi study

Kylie E. Hunter et al.

Summary: Individual participant data meta-analyses enable more detailed analyses by checking and cleaning data quality, but there is limited guidance on how to conduct these checks. This study aims to develop a checklist to improve data quality for individual participant data meta-analyses of randomized trials.

PLOS ONE (2022)

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Article Obstetrics & Gynecology

The hematological impact of umbilical cord milking versus delayed cord clamping in premature neonates: a randomized controlled trial

Hytham Atia et al.

Summary: The study compared the hematological impact of umbilical cord milking (UCM) and delayed cord clamping (DCC) in preterm neonates, and found that UCM was as effective as DCC in facilitating placental transfusion. However, UCM was associated with increased rates of interventions and morbidities, especially in extremely preterm neonates.

BMC PREGNANCY AND CHILDBIRTH (2022)

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Article Obstetrics & Gynecology

The DUC trial: a pilot randomized controlled trial of immediate versus delayed cord clamping in preterm infants born between 24 and 32 weeks gestation

Kelly S. Chu et al.

Summary: The study showed that a short delay in umbilical cord clamping (30-45 s) is feasible for women and physicians. The incidence of IVH and sepsis was the same in both groups, but a higher percentage of the ICC group required a blood transfusion, while the DCC group had a slightly lower incidence of hyperbilirubinemia requiring phototherapy. Further larger scale studies of long term outcomes are warranted.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2021)

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Article Pediatrics

Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial

Mohammed Yunis et al.

Summary: The study concluded that delayed cord clamping (DCC) in preterm infants with placental insufficiency increased stem cell transfusion and decreased episodes of early- and late-onset anemia compared to immediate cord clamping (ICC).

EUROPEAN JOURNAL OF PEDIATRICS (2021)

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Editorial Material Health Care Sciences & Services

Methodology over metrics: current scientific standards are a disservice to patients and society

Ben Van Calster et al.

Summary: Medical research quality remains poor due to the longstanding undervaluation of methodology in science. Despite various improvement initiatives, the overall system is disjointed and slow to adapt, requiring top-down actions from journals, universities, funders, and governments to break the cycle.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Review Pediatrics

Umbilical Cord Management for Newborns <34 Weeks' Gestation: A Meta-analysis

Anna Lene Seidler et al.

Summary: From the comprehensive analysis of 42 randomized controlled trials, it was found that delayed cord clamping and intact-cord milking may slightly improve survival compared to early cord clamping. Both methods probably improve hematologic measures but may not affect major neonatal morbidities.

PEDIATRICS (2021)

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Article Mathematical & Computational Biology

Data sharing-trialists' plans at registration, attitudes, barriers and facilitators: A cohort study and cross-sectional survey

Aidan Christopher Tan et al.

Summary: The study found that while investigators showed strong support for the concept of data sharing, their actual intention to share data from their clinical trials was low. Major barriers to data sharing included lacking informed consent, protecting confidentiality, and preventing data misinterpretation.

RESEARCH SYNTHESIS METHODS (2021)

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Article Pediatrics

Core outcomes in neonatology: development of a core outcome set for neonatal research

James William Harrison Webbe et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2020)

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Editorial Material Obstetrics & Gynecology

Data integrity of 35 randomised controlled trials in women' health

Esmee M. Bordewijk et al.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2020)

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Review Medicine, General & Internal

Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol

Anna Lene Seidler et al.

BMJ OPEN (2020)

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Article Obstetrics & Gynecology

Network meta-analyses in reproductive medicine: challenges and opportunities

Rui Wang et al.

HUMAN REPRODUCTION (2020)

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Article Medicine, General & Internal

Apgar Score and Risk of Neonatal Death among Preterm Infants

Sven Cnattingius et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Pediatrics

Effect of Umbilical Cord Milking vs Delayed Cord Clamping on Venous Hematocrit at 48 Hours in Late Preterm and Term Neonates: A Randomized Controlled Trial

Mukul Kumar Mangla et al.

INDIAN PEDIATRICS (2020)

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Article Pediatrics

Cord milking versus immediate clamping in preterm infants: a randomised controlled trial

Walid El-Naggar et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2019)

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Article Medicine, General & Internal

A guide to prospective meta-analysis

Anna Lene Seidler et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

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Article Pediatrics

Transfusion or Timing: The Role of Blood Volume in Delayed Cord Clamping During the Cardiovascular Transition at Birth

Fiona J. Stenning et al.

FRONTIERS IN PEDIATRICS (2019)

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Review Obstetrics & Gynecology

Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis

Michael Fogarty et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2018)

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Article Obstetrics & Gynecology

Placental transfusion in preterm neonates of 30-33 weeks' gestation: a randomized controlled trial

Bikramjit Das et al.

JOURNAL OF PERINATOLOGY (2018)

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Article Critical Care Medicine

Umbilical cord milking in preterm neonates requiring resuscitation: A randomized controlled trial

G. Ram Mohan et al.

RESUSCITATION (2018)

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Article Pediatrics

A new wrinkle: Umbilical cord management (how, when, who)

Anup Katheria et al.

SEMINARS IN FETAL & NEONATAL MEDICINE (2018)

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Review Pediatrics

Umbilical Cord Milking: A Review

Anup C. Katheria

FRONTIERS IN PEDIATRICS (2018)

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Article Pediatrics

Randomised trial of cord clamping and initial stabilisation at very preterm birth

Lelia Duley et al.

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2018)

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Article Pediatrics

Effect of delayed cord clamping on hematocrit, and thermal and hemodynamic stability in preterm neonates: A randomized controlled trial

Niraj Kumar Dipak et al.

INDIAN PEDIATRICS (2017)

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Article Medicine, General & Internal

Delayed versus Immediate Cord Clamping in Preterm Infants

W. Tarnow-Mordi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Medicine, General & Internal

Exploring changes over time and characteristics associated with data retrieval across individual participant data meta-analyses: systematic review

Sarah J. Nevitt et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Review Medicine, General & Internal

Exploring changes over time and characteristics associated with data retrieval across individual participant data meta-analyses: systematic review

Sarah J. Nevitt et al.

BMJ-BRITISH MEDICAL JOURNAL (2017)

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Article Pediatrics

Neonatal Resuscitation with an Intact Cord: A Randomized Clinical Trial

Anup Katheria et al.

JOURNAL OF PEDIATRICS (2016)

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Review Pediatrics

Cardiovascular transition at birth: a physiological sequence

Stuart B. Hooper et al.

PEDIATRIC RESEARCH (2015)

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Review Medicine, General & Internal

Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use

Jayne F. Tierney et al.

PLOS MEDICINE (2015)

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Editorial Material Pediatrics

Effect of Early versus Delayed Cord Clamping on Hematological Status of Preterm Infants at 6 wk of Age

Thomas Ranjit et al.

INDIAN JOURNAL OF PEDIATRICS (2015)

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Article Pediatrics

The Effects of Umbilical Cord Milking on Hemodynamics and Neonatal Outcomes in Premature Neonates

Anup C. Katheria et al.

JOURNAL OF PEDIATRICS (2014)

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Article Medicine, General & Internal

SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials

An-Wen Chan et al.

ANNALS OF INTERNAL MEDICINE (2013)

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Article Pediatrics

Hemodynamic Effects of Delayed Cord Clamping in Premature Infants

Ross Sommers et al.

PEDIATRICS (2012)

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Article Medicine, General & Internal

CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials

Kenneth F. Schulz et al.

BMJ-BRITISH MEDICAL JOURNAL (2010)

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Article Medicine, General & Internal

Meta-analysis of individual participant data: rationale, conduct, and reporting

Richard D. Riley et al.

BMJ-BRITISH MEDICAL JOURNAL (2010)

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Article Obstetrics & Gynecology

Twin-to-twin delivery time interval: influencing factors and effect on short-term outcome of the second twin

Werner Stein et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2008)

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Article Obstetrics & Gynecology

Mode of delivery and the risk of delivery-related perinatal death among twins at term: a retrospective cohort study of 8073 births

GCS Smith et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2005)

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Article Obstetrics & Gynecology

Effect of inter-twin delivery time on Apgar scores of the second twin

E Erdemoglu et al.

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2003)

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Optimizing cord management for each preterm baby- Challenges of collating individual participant data and recommendations for future collaborative research

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