☆ 4.3 Review

Preclinical Imaging of Cardiovascular Disesase

SEMINARS IN NUCLEAR MEDICINE (2023)

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Review Cardiac & Cardiovascular Systems

The interplay of inflammation, exosomes and Ca2+ dynamics in diabetic cardiomyopathy

Santosh K. Sanganalmath et al.

Summary: Diabetes mellitus is a major risk factor for cardiovascular complications, and it is associated with high morbidity and mortality. Diabetic cardiomyopathy is characterized by reduced cardiac contractility, myocardial fibrosis, diastolic dysfunction, and chronic heart failure. Inflammation, changes in calcium handling, and cardiomyocyte loss play significant roles in the development and progression of this disease.

CARDIOVASCULAR DIABETOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long?

Leslie Cho et al.

Summary: Menopausal hormone therapy (HT) was widely used in the past, but declined due to cardiovascular risks. However, recent research has provided new insights into the timing, administration, and cardiovascular disease risk associated with HT. This review, led by the American College of Cardiology, aims to provide guidance on HT use for symptomatic women with cardiovascular disease risk.

CIRCULATION (2023)

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Review Cardiac & Cardiovascular Systems

Evolving concepts of the vulnerable atherosclerotic plaque and the vulnerable patient: implications for patient care and future research

Prakriti Gaba et al.

Summary: This article discusses the features of vulnerable plaques in coronary arteries, as well as the non-invasive and invasive diagnostic methods used to characterize them. It also explores the potential prognostic value of identifying vulnerable plaques and the future research needed to explore intensified pharmacological and focal treatments for these plaques.

NATURE REVIEWS CARDIOLOGY (2023)

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Review Urology & Nephrology

Youth-onset type 2 diabetes mellitus: an urgent challenge

Petter Bjornstad et al.

Summary: The incidence and prevalence of youth-onset type 2 diabetes mellitus (T2DM) and its complications are increasing worldwide. Youth-onset T2DM has a more aggressive clinical course compared to adult-onset T2DM or type 1 diabetes mellitus. Limited treatment options are available for children and adolescents with T2DM, and complications such as increased albuminuria often develop in late childhood or early adulthood. The rising rates of childhood obesity, sedentary lifestyles, and exposure to diabetes during pregnancy are important factors contributing to the epidemic of youth-onset T2DM. Disadvantaged populations are particularly at risk, suggesting a contribution of social and environmental factors. Understanding the mechanisms behind youth-onset T2DM is crucial for prevention and management strategies.

NATURE REVIEWS NEPHROLOGY (2023)

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Review Cardiac & Cardiovascular Systems

The Circadian Biology of Heart Failure

Nadim El Jamal et al.

Summary: Cardiac physiology is regulated by autonomous molecular clocks and the suprachiasmatic nucleus, exhibiting diurnal rhythms. Disrupting molecular clocks can lead to heart failure, and the time of day can condition myocardial response to injury. Human studies support the involvement of molecular clocks and circadian rhythms in the pathogenesis of heart failure. Certain circadian rhythms are maintained in heart failure patients, which can guide optimal timing of therapy. Manipulation of circadian rhythms and molecular clocks show promise in the prevention and treatment of heart failure.

CIRCULATION RESEARCH (2023)

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Review Cardiac & Cardiovascular Systems

Vascular inflammation and cardiovascular disease: review about the role of PET imaging

Antonio Maria Sammartino et al.

Summary: Inflammation is a critical factor in the development of atherothrombosis, and its quantification through imaging techniques like F-18-FDG-PET and F-18-NaF PET/CT can help identify high-risk patients for cardiovascular events. However, there are limitations in using these techniques in routine clinical practice.

INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Understanding the importance of quality control and quality assurance in preclinical PET/CT imaging

Wendy A. McDougald et al.

Summary: The fundamental principle of experimental design is emphasized in this article, highlighting the importance of researchers' understanding of technological equipment and instrument quality control and assurance. The crucial role of quality control and assurance in preclinical positron emission tomography/computed tomography is presented, along with suggested guidelines. The article also emphasizes the impact of experimental design on data continuity and animal welfare, and suggests improving the robustness of experimental design through validation or accreditation of scanner performance.

EJNMMI PHYSICS (2022)

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Article Medicine, Research & Experimental

Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity - Introducing High NET Affinity PET Probe 18F-AF78

Xinyu Chen et al.

Summary: This study demonstrates that F-18-AF78 is a high-affinity cardiac sympathetic nervous system imaging agent with favorable radiotracer kinetics across various species. It has strong potential for guiding specific interventions in cardiovascular medicine.

THERANOSTICS (2022)

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Article Cardiac & Cardiovascular Systems

Molecular imaging of cardiac CXCR4 expression in a mouse model of acute myocardial infarction using a novel 68Ga-mCXCL12 PET tracer

Mathias Johannes Zacherl et al.

Summary: The study shows the feasibility of noninvasive molecular imaging of cardiac CXCR4 expression using a novel, murine-based, and specific (68)Ga-mCXCL12 tracer both ex vivo and in vivo, with consistent results.

JOURNAL OF NUCLEAR CARDIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Multiparametric PET and MRI of myocardial damage after myocardial infarction: correlation of integrin αvβ3 expression and myocardial blood flow

Marcus R. Makowski et al.

Summary: Increased αvβ3 expression was observed in some patients after myocardial infarction, showing correlation with infarct size and restricted blood flow, but not solely dependent on perfusion effects.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Cardiac & Cardiovascular Systems

Assessing myocardial perfusion in suspected coronary artery disease: rationale and design of the second phase 3, open-label multi-center study of flurpiridaz (F-18) injection for positron emission tomography (PET) imaging

Jamieson M. Bourque et al.

Summary: This is the second phase 3 study of F-18 Flurpiridaz PET MPI in diagnosing CAD, aiming to evaluate its diagnostic efficacy in suspected CAD patients and compare it with Tc-99m-labeled SPECT MPI. The trial design differs from the first phase 3 trial by excluding known CAD patients and requiring both SPECT and PET MPI to be performed before ICA. This study will provide additional evidence on the diagnostic efficacy of F-18 Flurpiridaz PET MPI in detecting significant CAD.

JOURNAL OF NUCLEAR CARDIOLOGY (2021)

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Article Multidisciplinary Sciences

Development and preclinical evaluation of novel fluorinated ammonium salts for PET myocardial perfusion imaging

Ofer Shamni et al.

Summary: The study aimed to increase the clinical applicability of PET-MPI by designing and synthesizing fluorinated ammonium salt derivatives and quinolinium salt analogs. Results showed that fluorinated DMDPA derivatives exhibited lower heart/liver radioactivity uptake ratios, while radiolabeled quinolinium salt derivatives demonstrated improved heart/liver ratios and clear visualization of the left ventricle myocardium. Renal clearance was the major route of elimination, with [F-18]FEtQ showing the best images among the fluorinated quaternary ammonium salts tested. Further studies are needed to elucidate the underlying mechanism of its cardiac uptake.

SCIENTIFIC REPORTS (2021)

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Review Biochemistry & Molecular Biology

Imaging Inflammation with Positron Emission Tomography

Janette Iking et al.

Summary: Inflammation plays a significant role in various medical conditions, but imaging has not been extensively utilized in research and management, as compared to neurological, oncologic, and cardiovascular disorders. Imaging provides valuable insights into the biology and grade of inflammation, which can be beneficial for diagnosis, treatment, and prognosis. It is essential to evaluate current approaches and potential applications for imaging of inflammation.

BIOMEDICINES (2021)

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Article Cardiac & Cardiovascular Systems

From Systemic Inflammation to Myocardial Fibrosis The Heart Failure With Preserved Ejection Fraction Paradigm Revisited

Walter J. Paulus et al.

Summary: According to the comorbidity-inflammation paradigm, comorbidities, especially metabolic ones, are believed to drive the development and severity of heart failure with preserved ejection fraction. Recent evidence includes myocardial infiltration, inducible nitric oxide synthase expression, patient phenogroups, and direct connections between comorbidities, inflammatory biomarkers, and abnormal myocardial structure/function.

CIRCULATION RESEARCH (2021)

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Article Cardiac & Cardiovascular Systems

Cardiac Energy Metabolism in Heart Failure

Gary D. Lopaschuk et al.

Summary: Changes in cardiac energy metabolism are complex and depend on the severity and type of heart failure, as well as the presence of common comorbidities such as obesity and type 2 diabetes. The failing heart experiences an energy deficit due to decreased mitochondrial oxidative capacity, compensated for by increased ATP production from glycolysis. Alterations in mitochondrial ATP production fuels and fatty acid oxidation contribute to the inefficiency of the failing heart, with potential therapeutic targets in energy metabolic pathways to improve cardiac function.

CIRCULATION RESEARCH (2021)

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Review Pharmacology & Pharmacy

Therapeutic angiogenesis in coronary artery disease: a review of mechanisms and current approaches

Bharat Narasimhan et al.

Summary: Although there have been significant advances in therapies for coronary disease, there is still a need to develop novel treatments due to the disease remaining a leading cause of death in many parts of the world. This paper provides an overview of native angiogenesis mechanisms, angiogenic growth factors, gene and stem cell therapy advances, and investigational approaches to promote angiogenesis. However, clinically meaningful therapeutic options for angiogenesis remain elusive due to the complexity of the process and challenges in translating promising animal studies to human trials.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2021)

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Review Cardiac & Cardiovascular Systems

Acquisition, Processing, and Interpretation of PET 18F-FDG Viability and Inflammation Studies

Emel Celiker-Guler et al.

Summary: F-18-FDG PET imaging is a valuable tool for assessing myocardial viability and inflammation, allowing for differentiation between hibernating and infarcted myocardial regions. It is also useful in conditions like cardiac sarcoidosis, where increased glucose utilization in inflammatory cells can be detected through the uptake of F-18-FDG. With careful patient preparation, F-18-FDG PET provides valuable insights into cardiac viability and inflammatory processes.

CURRENT CARDIOLOGY REPORTS (2021)

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Review Peripheral Vascular Disease

Role of Microparticles in Cardiovascular Disease Implications for Endothelial Dysfunction, Thrombosis, and Inflammation

Leslie Marisol Lugo-Gavidia et al.

Summary: Microparticles are small cell vesicles derived from the cell membrane, with growing evidence linking them to cardiovascular disease through inflammation, endothelial function, and thrombosis. Research on the direct causal link between microparticle release and their implications on physiological and pathological conditions is ongoing.

HYPERTENSION (2021)

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Article Chemistry, Medicinal

EANM guideline for harmonisation on molar activity or specific activity of radiopharmaceuticals: impact on safety and imaging quality

Gert Luurtsema et al.

Summary: This guideline focuses on the molar activity and specific activity of radiolabelled small molecules, peptides, and macromolecules for diagnostic and therapeutic applications. It describes the standardisation and harmonisation of these measurements, discusses the importance of A(m) and A(s) in imaging studies of saturable binding sites, and highlights the necessity of using appropriate materials and equipment. Additionally, common pitfalls and remedies in molar activity are described, along with considerations related to the emergence of highly sensitive PET scanners.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Initial Evaluation of AF78: a Rationally Designed Fluorine-18-Labelled PET Radiotracer Targeting Norepinephrine Transporter

Xinyu Chen et al.

MOLECULAR IMAGING AND BIOLOGY (2020)

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Review Clinical Neurology

Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements

Xinyu Chen et al.

JOURNAL OF NEURAL TRANSMISSION (2020)

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Article Cardiac & Cardiovascular Systems

Phase-III Clinical Trial of Fluorine-18 Flurpiridaz Positron Emission Tomography for Evaluation of Coronary Artery Disease

Jamshid Maddahi et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

Why the preclinical imaging field needs nuclear medicine technologists and radiographers?

J-P Dillenseger et al.

EUROPEAN JOURNAL OF HYBRID IMAGING (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Reproducibility and Comparability of Preclinical PET Imaging Data: A Multicenter Small-Animal PET Study

Julia G. Mannheim et al.

JOURNAL OF NUCLEAR MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis

Rudolf A. Werner et al.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2019)

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Article Engineering, Biomedical

Evaluation of pinhole collimator materials for micron-resolution ex vivo SPECT

Minh Phuong Nguyen et al.

PHYSICS IN MEDICINE AND BIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: Functional assessment using in vitro radionuclide uptake assay

Naoko Nose et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Impact of Novel Antidepressants on Cardiac 123I-Metaiodobenzylguanidine Uptake: Experimental Studies on SK-N-SH Cells and Healthy Rabbits

Rudolf A. Werner et al.

JOURNAL OF NUCLEAR MEDICINE (2018)

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Article Multidisciplinary Sciences

The Impact of Ageing on 11C-Hydroxyephedrine Uptake in the Rat Heart

Rudolf A. Werner et al.

SCIENTIFIC REPORTS (2018)

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Article Medicine, Research & Experimental

Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI

Christian Hundshammer et al.

THERANOSTICS (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer 68Ga-Pentixafor for PET

Fabien Hyafil et al.

JOURNAL OF NUCLEAR MEDICINE (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

Guidance for Efficient Small Animal Imaging Quality Control

Dustin R. Osborne et al.

MOLECULAR IMAGING AND BIOLOGY (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

Implementation of absolute quantification in small-animal SPECT imaging: Phantom and animal studies

Shabnam Khorasani Gerdekoohi et al.

JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS (2017)

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Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Addressing Technetium-99m Shortage

Mahadevappa Mahesh et al.

JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY (2017)

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Review Radiology, Nuclear Medicine & Medical Imaging

Preclinical imaging anesthesia in rodents

Giancarlo Vesce et al.

QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366

Calogero D'Alessandria et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2016)

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Article Cardiac & Cardiovascular Systems

Upregulated myocardial CXCR4-expression after myocardial infarction assessed by simultaneous GA-68 pentixafor PET/MRI

C. Rischpler et al.

JOURNAL OF NUCLEAR CARDIOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Derivation of a respiration trigger signal in small animal list-mode PET based on respiration-induced variations of the ECG signal

Andrei Todica et al.

JOURNAL OF NUCLEAR CARDIOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Utility of positron emission tomography for drug development for heart failure

Lampros Papadimitriou et al.

AMERICAN HEART JOURNAL (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

11C-Methionine PET of Myocardial Inflammation in a Rat Model of Experimental Autoimmune Myocarditis

Yoshifumi Maya et al.

JOURNAL OF NUCLEAR MEDICINE (2016)

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Review Cell Biology

Chemokines and Heart Disease: A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems

Veronica Dusi et al.

MEDIATORS OF INFLAMMATION (2016)

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Article Physiology

Glucose Transporters in Cardiac Metabolism and Hypertrophy

Dan Shao et al.

COMPREHENSIVE PHYSIOLOGY (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

First determination of the heart-to-mediastinum ratio using cardiac dual isotope (123I-MIBG/99mTc-tetrofosmin) CZT imaging in patients with heart failure: the ADRECARD study

Dimitri Bellevre et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Impact of Image-Derived Input Function and Fit Time Intervals on Patlak Quantification of Myocardial Glucose Uptake in Mice

James T. Thackeray et al.

JOURNAL OF NUCLEAR MEDICINE (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Comparison of 18F-Labeled Fluoroalkylphosphonium Cations with 13N-NH3 for PET Myocardial Perfusion Imaging

Dong-Yeon Kim et al.

JOURNAL OF NUCLEAR MEDICINE (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Ultra-High-Sensitivity Submillimeter Mouse SPECT

Oleksandra Ivashchenko et al.

JOURNAL OF NUCLEAR MEDICINE (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG

Rudolf A. Werner et al.

JOURNAL OF NUCLEAR MEDICINE (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Effects of CT-based attenuation correction of rat microSPECT images on relative myocardial perfusion and quantitative tracer uptake

Jared H. Strydhorst et al.

MEDICAL PHYSICS (2015)

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Review Radiology, Nuclear Medicine & Medical Imaging

Review of SPECT collimator selection, optimization, and fabrication for clinical and preclinical imaging

Karen Van Audenhaege et al.

MEDICAL PHYSICS (2015)

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Letter Cardiac & Cardiovascular Systems

[68Ga]Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction

Constantin Lapa et al.

JACC-CARDIOVASCULAR IMAGING (2015)

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Article Medicine, Research & Experimental

Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging

Hans Juergen Wester et al.

THERANOSTICS (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Molecular imaging of angiogenesis after myocardial infarction by 111In-DTPA-cNGR and 99mTc-sestamibi dual-isotope myocardial SPECT

Geert Hendrikx et al.

EJNMMI RESEARCH (2015)

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Article Biochemical Research Methods

Quarter-Millimeter-Resolution Molecular Mouse Imaging with U-SPECT+

Oleksandra Ivashchenko et al.

MOLECULAR IMAGING (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Clinically relevant strategies for lowering cardiomyocyte glucose uptake for 18F-FDG imaging of myocardial inflammation in mice

James T. Thackeray et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

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Editorial Material Cardiac & Cardiovascular Systems

A new F-18 labeled PET tracer for fatty acid imaging

Fabian Demeure et al.

JOURNAL OF NUCLEAR CARDIOLOGY (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat

Asuka Mizutani et al.

EJNMMI PHYSICS (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance

Christian Vanhove et al.

EJNMMI PHYSICS (2015)

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Article Cardiac & Cardiovascular Systems

Non-invasive diagnosis of coronary artery disease by 123I-BMIPP/201TlCl dual myocardial SPECT in patients with heart failure

Hajime Abe et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)

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Article Radiology, Nuclear Medicine & Medical Imaging

Small-Animal PET Imaging of Isolated Perfused Rat Heart

Tomohiko Yamane et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

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Article Radiology, Nuclear Medicine & Medical Imaging

Performance Assessment of a Preclinical PET Scanner with Pinhole Collimation by Comparison to a Coincidence-Based Small-Animal PET Scanner

Matthew D. Walker et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

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Article Medicine, Research & Experimental

Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of 68Ga-NOPO-c(RGDfK)

Jakub Simecek et al.

MOLECULAR PHARMACEUTICS (2014)

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Editorial Material Cell Biology

Oxidative Stress and Inflammation in Obesity, Diabetes, Hypertension, and Related Cardiometabolic Complications

Joseph Fomusi Ndisang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

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Review Radiology, Nuclear Medicine & Medical Imaging

Cardiac PET Perfusion Tracers: Current Status and Future Directions

Jamshid Maddahi et al.

SEMINARS IN NUCLEAR MEDICINE (2014)

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Article Cardiac & Cardiovascular Systems

PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis

Ambros J. Beer et al.

JACC-CARDIOVASCULAR IMAGING (2014)

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Article Chemistry, Medicinal

Synthesis and bioevaluation of [18F]4-fluoro-m-hydroxyphenethylguanidine ([18F]4F-MHPG): A novel radiotracer for quantitative PET studies of cardiac sympathetic innervation

Keun Sam Jang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

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Review Oncology

Molecular markers to predict outcome to antiangiogenic therapies in colorectal cancer: Current evidence and future perspectives

Ana Custodio et al.

CANCER TREATMENT REVIEWS (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Discrepant uptake of the radiolabeled norepinephrine analogues hydroxyephedrine (HED) and metaiodobenzylguanidine (MIBG) in rat hearts

Christoph Rischpler et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2013)

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Article Chemistry, Medicinal

4-[18F]Fluoro-m-hydroxyphenethylguanidine: A Radiopharmaceutical for Quantifying Regional Cardiac Sympathetic Nerve Density with Positron Emission Tomography

Keun Sam Jang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET

Marlies C. Goorden et al.

JOURNAL OF NUCLEAR MEDICINE (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Quantitative PET Imaging Detects Early Metabolic Remodeling in a Mouse Model of Pressure-Overload Left Ventricular Hypertrophy In Vivo

Min Zhong et al.

JOURNAL OF NUCLEAR MEDICINE (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Assessment of the 18F-Labeled PET Tracer LMI1195 for Imaging Norepinephrine Handling in Rat Hearts

Takahiro Higuchi et al.

JOURNAL OF NUCLEAR MEDICINE (2013)

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Article Cardiac & Cardiovascular Systems

Phase II Safety and Clinical Comparison With Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease Flurpiridaz F 18 Positron Emission Tomography

Daniel S. Berman et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Improved Derivation of Input Function in Dynamic Mouse [F-18]FDG PET Using Bladder Radioactivity Kinetics

Koon-Pong Wong et al.

MOLECULAR IMAGING AND BIOLOGY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Rat Imaging and In Vivo Stability Studies using [11C]- Dimethyl-Diphenyl Ammonium, a Candidate Agent for PET-Myocardial Perfusion Imaging

Orit Jacobson et al.

NUCLEAR MEDICINE AND BIOLOGY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Cardiac retention of PET neuronal imaging agent LMI1195 in different species: Impact of norepinephrine uptake-1 and-2 transporters

Ming Yu et al.

NUCLEAR MEDICINE AND BIOLOGY (2013)

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Review Medicine, Research & Experimental

PET Imaging of Inflammation Biomarkers

Chenxi Wu et al.

THERANOSTICS (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Gating, enhanced gating, and beyond: information utilization strategies for motion management, applied to preclinical PET

Adam Leon Kesner et al.

EJNMMI RESEARCH (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

LMI1195 PET imaging in evaluation of regional cardiac sympathetic denervation and its potential role in antiarrhythmic drug treatment

Ming Yu et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2012)

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Article Cardiac & Cardiovascular Systems

Reproducibility and accuracy of non-invasive measurement of infarct size in mice with high-resolution PET/CT

Adelaide Greco et al.

JOURNAL OF NUCLEAR CARDIOLOGY (2012)

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Article Cardiac & Cardiovascular Systems

Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques

Antti Saraste et al.

JOURNAL OF NUCLEAR CARDIOLOGY (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Advances in Preclinical SPECT Instrumentation

Todd E. Peterson et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for α- and β--Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

Cristina Mueller et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Molecular Imaging of Early αvβ3 Integrin Expression Predicts Long-Term Left-Ventricle Remodeling After Myocardial Infarction in Rats

Hossam M. Sherif et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Structure-Activity Relationship and Preclinical Evaluation of Carbon-11-Labeled Ammonium Salts as PET-Myocardial Perfusion Imaging Agents

Ohad Ilovich et al.

MOLECULAR IMAGING AND BIOLOGY (2012)

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Article Engineering, Biomedical

Quantification accuracy and partial volume effect in dependence of the attenuation correction of a state-of-the-art small animal PET scanner

Julia G. Mannheim et al.

PHYSICS IN MEDICINE AND BIOLOGY (2012)

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Article Cardiac & Cardiovascular Systems

Cardiovascular Molecular Imaging Focus on Clinical Translation

Ian Y. Chen et al.

CIRCULATION (2011)

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Article Cardiac & Cardiovascular Systems

Evaluation of LMI1195, a Novel 18F-Labeled Cardiac Neuronal PET Imaging Agent, in Cells and Animal Models

Ming Yu et al.

CIRCULATION-CARDIOVASCULAR IMAGING (2011)

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Article Radiology, Nuclear Medicine & Medical Imaging

Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest

Jamshid Maddahi et al.

JOURNAL OF NUCLEAR MEDICINE (2011)

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Article Radiology, Nuclear Medicine & Medical Imaging

PET of CXCR4 Expression by a 68Ga-Labeled Highly Specific Targeted Contrast Agent

Eleni Gourni et al.

JOURNAL OF NUCLEAR MEDICINE (2011)

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Review Radiology, Nuclear Medicine & Medical Imaging

The Next Generation of Cardiac Positron Emission Tomography Imaging Agents: Discovery of Flurpiridaz F-18 for Detection of Coronary Disease

Ming Yu et al.

SEMINARS IN NUCLEAR MEDICINE (2011)

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Review Cardiac & Cardiovascular Systems

Assessment of myocardial ischaemia and viability: role of positron emission tomography

Nina Ghosh et al.

EUROPEAN HEART JOURNAL (2010)

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Article Radiology, Nuclear Medicine & Medical Imaging

Molecular Imaging of Cardiac Sympathetic Innervation by 11C-mHED and PET: From Man to Mouse?

Marilyn P. Law et al.

JOURNAL OF NUCLEAR MEDICINE (2010)

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Article Radiology, Nuclear Medicine & Medical Imaging

Synthesis and Preliminary Evaluation of 18-18F-Fluoro-4-Thia-Oleate as a PET Probe of Fatty Acid Oxidation

Timothy R. DeGrado et al.

JOURNAL OF NUCLEAR MEDICINE (2010)

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Article Cardiac & Cardiovascular Systems

Evaluation of the Novel Myocardial Perfusion Positron-Emission Tomography Tracer 18F-BMS-747158-02 Comparison to 13N-Ammonia and Validation With Microspheres in a Pig Model

S. G. Nekolla et al.

CIRCULATION (2009)

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Article Cardiac & Cardiovascular Systems

Evaluation of a Novel 18F-Labeled Positron-Emission Tomography Perfusion Tracer for the Assessment of Myocardial Infarct Size in Rats

Hossam M. Sherif et al.

CIRCULATION-CARDIOVASCULAR IMAGING (2009)

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Article Cardiac & Cardiovascular Systems

Evaluation of αvβ3 Integrin-Targeted Positron Emission Tomography Tracer 18F-Galacto-RGD for Imaging of Vascular Inflammation in Atherosclerotic Mice

Iina Laitinen et al.

CIRCULATION-CARDIOVASCULAR IMAGING (2009)

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Article Immunology

Autoimmune myocarditis: Past, present and future

Florian Leuschner et al.

JOURNAL OF AUTOIMMUNITY (2009)

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Article Radiology, Nuclear Medicine & Medical Imaging

Combined Reporter Gene PET and Iron Oxide MRI for Monitoring Survival and Localization of Transplanted Cells in the Rat Heart

Takahiro Higuchi et al.

JOURNAL OF NUCLEAR MEDICINE (2009)

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Article Cardiac & Cardiovascular Systems

Stress Thallium-201/Rest Technetium-99m Sequential Dual Isotope High-Speed Myocardial Perfusion Imaging

Daniel S. Berman et al.

JACC-CARDIOVASCULAR IMAGING (2009)

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Article Anesthesiology

Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats

Coert J. Zuurbier et al.

ANESTHESIA AND ANALGESIA (2008)

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Article Hematology

G-CSF treatment after myocardial infarction: Impact on bone marrow-derived vs cardiac progenitor cells

Stefan Brunner et al.

EXPERIMENTAL HEMATOLOGY (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

A New 18F-Labeled Myocardial PET Tracer: Myocardial Uptake After Permanent and Transient Coronary Occlusion in Rats

Takahiro Higuchi et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Spillover and partial-volume correction for image-derived input functions for small-animal 18F-FDG PET studies

Yu-Hua Dean Fang et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Initial characterization of an 18F-labeled myocardial perfusion tracer

Marc C. Huisman et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Spatial and temporal heterogeneity of regional myocardial uptake in patients without heart disease under fasting conditions on repeated whole-body 18F-FDG PET/CT

Eugenio Inglese et al.

JOURNAL OF NUCLEAR MEDICINE (2007)

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Article Radiology, Nuclear Medicine & Medical Imaging

Myocardial kinetics of 201Thallium, 99mTc-tetrofosmin, and 99mTc-sestamibi in an acute ischemia-reperfusion model using isolated rat heart

Kenji Fukushima et al.

ANNALS OF NUCLEAR MEDICINE (2007)

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Article Cardiac & Cardiovascular Systems

Cardiovascular magnetic resonance perfusion imaging at 3-Tesla for the detection of coronary artery disease - A comparison with 1.5-Tesla

Adrian S. H. Cheng et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)

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Article Engineering, Electrical & Electronic

First-pass angiography in mice using FDG-PET: A simple method of deriving the cardiovascular transit time without the need of region-of-interest drawing

HM Wu et al.

IEEE TRANSACTIONS ON NUCLEAR SCIENCE (2005)

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Article Biochemical Research Methods

[F-18]Galacto-RGD: Synthesis, radiolabeling, metabolic stability, and radiation dose estimates

R Haubner et al.

BIOCONJUGATE CHEMISTRY (2004)

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Review Medicine, General & Internal

β-blocker therapy in heart failure -: Scientific review

JM Foody et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)

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Article Cardiac & Cardiovascular Systems

Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging - Comparison with positron emission tomography

C Klein et al.

CIRCULATION (2002)

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