Diagnostic Uncertainties in Tremor

Article Clinical Neurology

Functional Movement Disorders and Deep Brain Stimulation: A Multi-Center Study

Luca Marsili et al.

Summary: FMD is a commonly under-recognized diagnosis that may occur more often in patients undergoing DBS, especially those with pre-morbid psychiatric conditions. The prevalence and number of cases varied across centers.

MOVEMENT DISORDERS CLINICAL PRACTICE (2023)

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Review Clinical Neurology

The MDS consensus tremor classification: The best way to classify patients with tremor at present

Anna Latorre et al.

Summary: In 2018, the new Consensus Statement on the Classification of Tremors was published by the Task Force on Tremor of the International Parkinson Movement Disorder Society. The article has gained significant attention, being cited over 400 times and sparking discussions in conferences and meetings. The main novelties of the classification include the syndromic approach, the definition of essential tremor as a syndrome, and the recognition of essential tremor plus. This comprehensive and rigorous classification is deemed the best current approach based on our current knowledge of tremor syndromes.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

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Article Clinical Neurology

Longitudinal evaluation of patients with isolated head tremor

Gina Ferrazzano et al.

Summary: The study found that 75% of patients with isolated head tremor developed cervical dystonia 5 years later, while 25% still only had isolated head tremor. There was no significant change in head tremor severity between baseline and the 5-year follow-up.

PARKINSONISM & RELATED DISORDERS (2022)

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Article Clinical Neurology

Association of Essential Tremor With Novel Risk Loci A Genome-Wide Association Study and Meta-analysis

Calwing Liao et al.

Summary: This genome-wide association study identified five independent loci associated with essential tremor (ET), explaining approximately 18% of its heritability. Functional analysis revealed enrichment in cerebellar regions. Genetic correlation analysis showed overlap with Parkinson disease and depression, suggesting common genetic factors.

JAMA NEUROLOGY (2022)

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Review Clinical Neurology

The clinical and electrophysiological investigation of tremor

Guenther Deuschl et al.

Summary: The various forms of tremor are now classified based on clinical characteristics and etiology. Electrophysiology, as an extension of clinical examination, is valuable in diagnosing and characterizing different types of tremor. It also plays a crucial role in understanding the pathophysiology of tremor.

CLINICAL NEUROPHYSIOLOGY (2022)

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Article Multidisciplinary Sciences

Wearable sensors during drawing tasks to measure the severity of essential tremor

Sheik Mohammed Ali et al.

Summary: This study proposes the use of wearable accelerometer sensors for the quantitative assessment of essential tremor (ET). The results show that the sensor located on the forearm had the best classification and regression results, with moderate to good correlation between Fahn-Tolosa-Marin (FTM) scores and a combination of power spectral density ratio and task time. However, the system could not accurately differentiate ET phenotypes according to the Consensus classification scheme.

SCIENTIFIC REPORTS (2022)

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Review Clinical Neurology

Uncovering Essential Tremor Genetics: The Promise of Long-Read Sequencing

Luca Marsili et al.

Summary: Long-read sequencing (LRS) technologies have been introduced to overcome limitations of next-generation sequencing (NGS) technologies and have been successful in unraveling hidden mutational mechanisms. In the field of clinical neurology, LRS can help uncover the genetic mechanisms of essential tremor (ET), particularly genetic subtypes with associated leukoencephalopathy or family history of epilepsy.

FRONTIERS IN NEUROLOGY (2022)

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Article Clinical Neurology

Are smartphones and machine learning enough to diagnose tremor?

Arjun Balachandar et al.

Summary: Machine learning classifiers achieved high accuracy in Parkinson's disease classification, but moderate accuracy in essential tremor classification and poor accuracy in dystonic tremor classification. This highlights the difficulty of using AI to classify tremors, possibly due to the lack of specificity in clinical and neuropathological features.

JOURNAL OF NEUROLOGY (2022)

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Review Clinical Neurology

Emerging concepts on bradykinesia in non-parkinsonian conditions

Giulia Paparella et al.

Summary: Bradykinesia is a common motor abnormality observed in various neurological diseases not primarily characterized by parkinsonism. The underlying pathophysiology of bradykinesia in these conditions may be related to dysfunction of brain networks. It is suggested that a more accurate and widely used definition of bradykinesia is needed in the context of movement disorders and other neurological conditions.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

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Review Clinical Neurology

Tremor Syndromes: An Updated Review

Abhishek Lenka et al.

Summary: Tremor is a common movement disorder in clinical practice, with a wide range of pathologies. The International Parkinson Disease and Movement Disorders Society has proposed a new classification system based on clinical features and etiology, which has become a significant topic in scientific discussions on tremor.

FRONTIERS IN NEUROLOGY (2021)

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Article Clinical Neurology

Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson's Disease in a Movement Disorders Clinic

Steven T. Bellows et al.

Summary: In a population of 300 essential tremor patients from a movement disorders clinic, 20.7% were classified as isolated essential tremor, 53.3% as essential tremor plus, and 26.0% as essential tremor-Parkinson's disease. Essential tremor plus patients were more likely to present with dystonia, tandem gait abnormalities, head tremor, and greater tremor severity. Essential tremor-Parkinson's disease patients were more likely to exhibit symptoms of REM sleep behavior disorder (RBD), and there was no significant difference in cognitive impairment between essential tremor plus and essential tremor-Parkinson's disease patients.

TREMOR AND OTHER HYPERKINETIC MOVEMENTS (2021)

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Article Clinical Neurology

Task Specific Tremor Subsequently Developing into Parkinson's Disease: Case Series

Vindhya Koneru et al.

Summary: This study reports 12 patients who initially presented with task specific tremor (TST) before developing Parkinson's Disease (PD). The rest tremor consistently occurred ipsilateral to the TST arm, with DaTscan showing reduced dopaminergic uptake. Patients showed a partial response to dopaminergic medications, suggesting TST may be a precursor to PD.

MOVEMENT DISORDERS CLINICAL PRACTICE (2021)

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Article Neurosciences

Tremor-Dominant Cervical Dystonia: a Cerebellar Syndrome

Abhimanyu Mahajan et al.

Summary: This study found that head tremor at onset in tremor-dominant subtype of cervical dystonia (CD) is associated with more severe axial cerebellar disability and atrophy of the superior vermis of the cerebellum.

CEREBELLUM (2021)

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Article Clinical Neurology

Quantitative Separation of Tremor and Ataxia in Essential Tremor

Agostina Casamento-Moran et al.

ANNALS OF NEUROLOGY (2020)

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Review Clinical Neurology

How have advances in genetic technology modified movement disorder nosology?

A. Sturchio et al.

EUROPEAN JOURNAL OF NEUROLOGY (2020)

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Article Clinical Neurology

Voice analysis in adductor spasmodic dysphonia: Objective diagnosis and response to botulinum toxin

Antonio Suppa et al.

PARKINSONISM & RELATED DISORDERS (2020)

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Article Clinical Neurology

Development and Validation of the Orthostatic Tremor Severity and Disability Scale (OT-10)

Aristide Merola et al.

MOVEMENT DISORDERS (2020)

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Editorial Material Neurosciences

The Shaking Shoelace

Bastiaan R. Bloem et al.

JOURNAL OF PARKINSONS DISEASE (2019)

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Article Clinical Neurology

Novel mutations in MYBPC1 are associated with myogenic tremor and mild myopathy

Janis Stavusis et al.

ANNALS OF NEUROLOGY (2019)

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Article Clinical Neurology

Head tremor at disease onset: an ataxic phenotype of cervical dystonia

Aristide Merola et al.

JOURNAL OF NEUROLOGY (2019)

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Review Medicine, General & Internal

Paraneoplastic movement disorders: phenomenology, diagnosis, and treatment

Martina Chirra et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2019)

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Article Clinical Neurology

Smartwatch for the analysis of rest tremor in patients with Parkinson's disease

Roberto Lopez-Blanco et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2019)

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Article Clinical Neurology

Diffusion tensor imaging in orthostatic tremor: a tract-based spatial statistics study

Julian Benito-Leon et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

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Article Clinical Neurology

A data mining approach for classification of orthostatic and essential tremor based on MRI-derived brain volume and cortical thickness

Julian Benito-Leon et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

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Review Neurosciences

Revisiting the Clinical Phenomenology of Cerebellar Tremor: Beyond the Intention Tremor

Abhishek Lenka et al.

CEREBELLUM (2019)

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Article Genetics & Heredity

Copy number variation of LINGO1 in familial dystonic tremor

Vafa Alakbarzade et al.

NEUROLOGY-GENETICS (2019)

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Article Clinical Neurology

Consensus Statement on the Classification of Tremors. From the Task Force on Tremor of the International Parkinson and Movement Disorder Society

Kailash P. Bhatia et al.

MOVEMENT DISORDERS (2018)

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Article Clinical Neurology

Functional neurological disorders in Parkinson disease

Benjamin D. Wissel et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

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Article Clinical Neurology

The nature of postural tremor in Parkinson disease

Michiel F. Dirkx et al.

NEUROLOGY (2018)

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Article Medicine, General & Internal

Essential Tremor

Dietrich Haubenberger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Clinical Neurology

The overlap between Essential tremor and Parkinson disease

Musleh Algarni et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Article Clinical Neurology

The etiology of essential tremor: Genes versus environment

Franziska Hopfner et al.

PARKINSONISM & RELATED DISORDERS (2018)

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Article Neuroimaging

Impaired emotion processing in functional (psychogenic) tremor: A functional magnetic resonance imaging study

Alberto J. Espay et al.

NEUROIMAGE-CLINICAL (2018)

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Editorial Material Clinical Neurology

Teaching Video NeuroImages: The signs of dystonic tremor Tremulous escanciador

Jennifer Sharma et al.

NEUROLOGY (2018)

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Article Clinical Neurology

Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD

Siddharth Arora et al.

NEUROLOGY (2018)

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Review Clinical Neurology

Essential Pitfalls in Essential Tremor

Alberto J. Espay et al.

MOVEMENT DISORDERS (2017)

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Review Clinical Neurology

Past, Present, and Future of Parkinson's Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy

J. A. Obeso et al.

MOVEMENT DISORDERS (2017)

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Article Clinical Neurology

Positional Tremor and its Treatment

Sara M. Schaefer et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2017)

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Article Clinical Neurology

Smartphone Apps Provide a Simple, Accurate Bedside Screening Tool for Orthostatic Tremor

Danish Bhatti et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2017)

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Article Neurosciences

Cognitive Stress Reduces the Effect of Levodopa on Parkinson's Resting Tremor

Heidemarie Zach et al.

CNS NEUROSCIENCE & THERAPEUTICS (2017)

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Review Clinical Neurology

The essential tremor syndromes

Rodger J. Elble

CURRENT OPINION IN NEUROLOGY (2016)

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Review Clinical Neurology

Unusual tremor syndromes: know in order to recognise

Robert J. Ure et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

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Article Clinical Neurology

Orthostatic tremor Clinical, electrophysiologic, and treatment findings in 184 patients

Anhar Hassan et al.

NEUROLOGY (2016)

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Article Clinical Neurology

Holmes tremor Clinical description, lesion localization, and treatment in a series of 29 cases

Gabriela B. Raina et al.

NEUROLOGY (2016)

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Article Clinical Neurology

Tremor pattern differentiates drug-induced resting tremor from Parkinson disease

R. Nistico et al.

PARKINSONISM & RELATED DISORDERS (2016)

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Letter Clinical Neurology

Psychogenic tremor in Parkinson's disease

Carlo Colosimo

ACTA NEUROLOGICA BELGICA (2015)

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Article Clinical Neurology

Tremor in the Elderly: Essential and Aging-Related Tremor

Guenther Deuschl et al.

MOVEMENT DISORDERS (2015)

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Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

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Article Chemistry, Analytical

Performance Evaluation of Smartphone Inertial Sensors Measurement for Range of Motion

Quentin Mourcou et al.

SENSORS (2015)

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Article Clinical Neurology

Rest and other types of tremor in adult-onset primary dystonia

Roberto Erro et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2014)

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Article Clinical Neurology

Tremor in Spinocerebellar Ataxia Type 12

Lorraine V. Kalia et al.

MOVEMENT DISORDERS CLINICAL PRACTICE (2014)

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Article Clinical Neurology

Tremor in inflammatory neuropathies

Tabish Aziz Saifee et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2013)

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Review Clinical Neurology

Movement disorders in multiple sclerosis and other demyelinating diseases

Raja Mehanna et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2013)

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Article Clinical Neurology

Tremor in neuropathies of different origin

Anna Wasielewska et al.

NEUROLOGIA I NEUROCHIRURGIA POLSKA (2013)

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Article Clinical Neurology

Tremor-Some Controversial Aspects

Niall P. Quinn et al.

MOVEMENT DISORDERS (2011)

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Article Clinical Neurology

Moving toward laboratory-supported criteria for psychogenic tremor

Petra Schwingenschuh et al.

MOVEMENT DISORDERS (2011)

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Article Clinical Neurology

Cohort study on somatoform disorders in Parkinson disease and dementia with Lewy bodies

Marco Onofrj et al.

NEUROLOGY (2010)

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Article Clinical Neurology

Trauma, stress, and preconscious threat processing in patients with psychogenic nonepileptic seizures

Patricia Bakvis et al.

EPILEPSIA (2009)

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Article Clinical Neurology

Clinically Deployable Kinesia™ Technology for Automated Tremor Assessment

Joseph P. Giuffrida et al.

MOVEMENT DISORDERS (2009)

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Article Genetics & Heredity

Variant in the sequence of the LINGO1 gene confers risk of essential tremor

Hreinn Stefansson et al.

NATURE GENETICS (2009)

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Article Clinical Neurology

Essential Head Tremor Is Associated with Cerebellar Vermis Atrophy: A Volumetric and Voxel-Based Morphometry MR Imaging Study

A. Quattrone et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2008)

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Article Clinical Neurology

Irregularity distinguishes limb tremor in cervical dystonia from essential tremor

A. G. Shaikh et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2008)

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Article Clinical Neurology

Prevalence of essential tremor in patients with Parkinson's disease vs. Parkinson-Plus syndromes

Elan D. Louis et al.

MOVEMENT DISORDERS (2007)

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Article Clinical Neurology

Essential tremor: Phenotypic expression in a clinical cohort

N. R. Whaley et al.

PARKINSONISM & RELATED DISORDERS (2007)

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Article Public, Environmental & Occupational Health

Does age of onset in essential tremor have a bimodal distribution? Data from a tertiary referral setting and a population-based study

Elan D. Louis et al.

NEUROEPIDEMIOLOGY (2007)

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Review Medicine, General & Internal

Differential diagnosis of common tremor syndromes

R Bhidayasiri

POSTGRADUATE MEDICAL JOURNAL (2005)

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Review Clinical Neurology

Drug-induced tremors

JC Morgan et al.

LANCET NEUROLOGY (2005)

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Article Clinical Neurology

Myoclonic tremulous movements in multiple system atrophy are a form of cortical myoclonus

Y Okuma et al.

MOVEMENT DISORDERS (2005)

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Review Clinical Neurology

The pathophysiology of tremor

G Deuschl et al.

MUSCLE & NERVE (2001)

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Article Clinical Neurology

Essential tremor and cerebellar dysfunction -: Clinical and kinematic analysis of intention tremor

G Deuschl et al.

BRAIN (2000)

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Diagnostic Uncertainties in Tremor

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