期刊
SEMINARS IN IMMUNOLOGY
卷 66, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2023.101710
关键词
Dendritic cell; MHC-dressing; Cross-presentation; CD8(+) T cell
类别
Dendritic cells play a crucial role in anti-tumor immune responses by activating cytotoxic CD8(+) T cells. In addition to cross-presentation, recent studies have found that MHC-dressing can also activate CD8(+) T cells against tumor cell-derived antigens. Understanding the specific contributions of MHC-dressing to anti-tumor immunity has potential for novel therapeutic approaches.
Dendritic cells are crucial for anti-tumor immune responses due to their ability to activate cytotoxic effector CD8(+) T cells. Canonically, in anti-tumor immunity, dendritic cells activate CD8(+) T cells in a process termed cross-presentation. Recent studies have demonstrated that another type of antigen presentation, MHC-dressing, also serves to activate CD8(+) T cells against tumor cell-derived antigens. Understanding MHC-dressing's specific contributions to anti-tumor immunity can open up novel therapeutic avenues. In this review, we summarize the early studies that identified MHC-dressing as a relevant antigen presentation pathway before diving into a deeper discussion of the biology of MHC-dressing, focusing in particular on which dendritic cell subsets are most capable of performing MHC-dressing and how MHC-dressing compares to other forms of antigen presentation. We conclude by discussing the implications MHC-dressing has for anti-tumor immunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据