4.8 Article

Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Transplantation

Heart failure in chronic kidney disease: the emerging role of myocardial fibrosis

Gregorio Romero-Gonzalez et al.

Summary: Heart failure is a major cause of morbidity and mortality in chronic kidney disease patients. Myocardial interstitial fibrosis (MIF), resulting from altered collagen turnover, contributes to the development of heart failure. Various mechanisms in different stages of chronic kidney disease may affect fibroblasts and collagen turnover in the heart. Therefore, understanding MIF could lead to the identification of biomarkers and targets for prevention and treatment of heart failure in chronic kidney disease patients.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

Article Urology & Nephrology

A prospective cohort study of acute kidney injury and kidney outcomes, cardiovascular events, and death

T. Alp Ikizler et al.

Summary: AKI is associated with adverse outcomes such as incident CKD, CKD progression, heart failure events, and all-cause death, but not major atherosclerotic cardiovascular events. Considering kidney function recovery and proteinuria status three months after AKI provides important prognostic information for long-term clinical outcomes.

KIDNEY INTERNATIONAL (2021)

Review Cell Biology

Inflammatory Chemokines in Atherosclerosis

Selin Gencer et al.

Summary: Atherosclerosis is a chronic inflammatory disease of the vessel wall leading to occlusive lesions in large arteries. Chemokines and their receptors play a key role in the development of atherosclerotic lesions by orchestrating immune cell activation and recruitment. Recent research has focused on targeting these chemokines for potential treatment of atherosclerosis.
Article Cardiac & Cardiovascular Systems

Cardiovascular Disease in Chronic Kidney Disease Pathophysiological Insights and Therapeutic Options

Joachim Jankowski et al.

Summary: Patients with chronic kidney disease face an increased risk of cardiovascular events, with advanced CKD stages significantly elevating the risk. Cardiovascular events, rather than end-stage kidney disease, are the leading cause of death in this high-risk population, and CKD causes a proinflammatory state that affects the cardiovascular system.

CIRCULATION (2021)

Review Endocrinology & Metabolism

Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling

Anbarasi Kothandapani et al.

Summary: This article discusses the crucial role of cholesterol during fetal masculinization, particularly in androgen synthesis and HH signaling activity, emphasizing its functional importance in promoting male sex differentiation. Perturbations in cholesterol synthesis may lead to developmental defects such as VSD, similar to those caused by disrupted androgen or HH signaling pathways.

ENDOCRINOLOGY (2021)

Article Multidisciplinary Sciences

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Yoshiharu Muto et al.

Summary: The integration of single cell transcriptome and chromatin accessibility datasets provides deeper insights into cell heterogeneity, demonstrating the potential of single nucleus ATAC-seq in the identification of cell identity and functional heterogeneity. Differentially accessible chromatin regions in promoters associated with differentially expressed genes suggest the involvement of transcription factors like NF-kappa B in driving transitions between cell subpopulations within the kidney. This multi-omics approach improves the detection of unique cell states and redefines cellular heterogeneity in specific regions of the kidney.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis

Yuya Yoshida et al.

Summary: Dysfunction of the circadian clock is linked to cardiovascular disease pathogenesis. Even in the presence of high blood pressure and elevated levels of angiotensin II, Clk/Clk mice with chronic kidney disease show reduced cardiac inflammation and fibrosis. The monocytic expression of GPR68, induced by altered CLOCK activation, exacerbates heart inflammation and fibrosis under CKD conditions.

NATURE COMMUNICATIONS (2021)

Article Urology & Nephrology

Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis

Yueh-An Lu et al.

Summary: This study utilized snRNAseq to describe the phenotype of proximal tubular cells (PTCs) in renal fibrosis, revealing previously unrecognized heterogeneity and novel PTC clusters associated with kidney fibrosis. Comprehensive pathway analyses showed metabolic reprogramming, cellular communication and cell motility enrichment, and immune activations in new PTC clusters. Ligand-receptor analysis indicated that new PTC clusters promoted fibrotic signaling to fibroblasts and inflammatory activation to macrophages.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Multidisciplinary Sciences

Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury

Louisa M. S. Gerhardt et al.

Summary: The study found that even mild to moderate ischemia-reperfusion injury can cause lasting damage, spreading from the cortico-medullary boundary (CMB) to cortical regions, and the remaining failed-repair PTCs may be triggers for chronic disease progression.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biology

Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

Shintaro Ide et al.

Summary: The study reveals that proximal tubular cells develop a pro-inflammatory state following injury, which can lead to persistent inflammation and fibrosis. After mild injury, these inflammatory PT cells transiently appear and make the cells vulnerable to ferroptotic stress; while after severe injury, they accumulate and enhance inflammation and fibrosis.
Article Cardiac & Cardiovascular Systems

Cardiac biomarkers in chronic kidney disease are independently associated with myocardial edema and diffuse fibrosis by cardiovascular magnetic resonance

Luca Arcari et al.

Summary: The study demonstrates close associations between cardiac biomarkers including high sensitivity cardiac troponin T (hs-cTnT) and NT-pro-brain natriuretic peptide (NT-pro BNP) with quantitative imaging measures of myocardial fibrosis and edema by T1 and T2 mapping in patients with chronic kidney disease. Native T1 and T2 were significantly associated with worsening CKD in patients, and hs-cTnT and NT-pro BNP correlated with T1 and T2 mapping in patients with lower estimated glomerular filtration rate, suggesting the role of diffuse non-ischemic tissue processes in CKD-related cardiac remodeling.

JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE (2021)

Review Endocrinology & Metabolism

Cholesterol Contributes to Male Sex Differentiation Through Its Developmental Role in Androgen Synthesis and Hedgehog Signaling

Anbarasi Kothandapani et al.

Summary: The article explores the roles of cholesterol as a precursor for androgen synthesis and in supporting HH signaling activity during fetal development, highlighting the importance of interactions between HH and androgen signaling pathways, and the functional role of cholesterol in promoting male sex differentiation.

ENDOCRINOLOGY (2021)

Article Urology & Nephrology

Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis

Xi Liu et al.

KIDNEY INTERNATIONAL (2020)

Article Multidisciplinary Sciences

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

Nicole Almanzar et al.

NATURE (2020)

Article Multidisciplinary Sciences

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

Yuhei Kirita et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Urology & Nephrology

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease

Bryan R. Conway et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Article Biochemistry & Molecular Biology

Irradiation of the kidneys causes pathologic remodeling in the nontargeted heart: A role for the immune system

Marek Lenarczyk et al.

FASEB BIOADVANCES (2020)

Review Biochemistry & Molecular Biology

Regulation of Hedgehog signaling Offers A Novel Perspective for Bone Homeostasis Disorder Treatment

Wen-Ting Lv et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Urology & Nephrology

Immunology of the ageing kidney

Yuki Sato et al.

NATURE REVIEWS NEPHROLOGY (2019)

Review Cardiac & Cardiovascular Systems

Guidelines for measuring cardiac physiology in mice

Merry L. Lindsey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Review Pharmacology & Pharmacy

Perivascular fibrosis and the microvasculature of the heart. Still hidden secrets of pathophysiology?

Kirsti Ytrehus et al.

VASCULAR PHARMACOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Sonic hedgehog signaling regulates the mammalian cardiac regenerative response

Hiroyuki Kawagishi et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Upstream Hedgehog signaling components are exported in exosomes of cervical cancer cell lines

Anjali Bhat et al.

NANOMEDICINE (2018)

Article Urology & Nephrology

Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury

Rafael Kramann et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Review Physiology

Tumor necrosis factor-α, kidney function, and hypertension

Eamonn Mehaffey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

Review Biochemistry & Molecular Biology

Hh signaling in regeneration of the ischemic heart

Marina Dunaeva et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Article Urology & Nephrology

Tubular Epithelial NF-κB Activity Regulates Ischemic AKI

Lajos Marko et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2016)

Review Urology & Nephrology

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

Maria Edeling et al.

NATURE REVIEWS NEPHROLOGY (2016)

Review Transplantation

Hedgehog Gli signalling in kidney fibrosis

Rafael Kramann

NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

Article Multidisciplinary Sciences

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

Eunjeong Seo et al.

SCIENTIFIC REPORTS (2016)

Article Biotechnology & Applied Microbiology

Classification of low quality cells from single-cell RNA-seq data

Tomislav Ilicic et al.

GENOME BIOLOGY (2016)

Article Medicine, Research & Experimental

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney

Yuki Sato et al.

JCI INSIGHT (2016)

Article Cell & Tissue Engineering

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

Rafael Kramann et al.

CELL STEM CELL (2015)

Article Medicine, Research & Experimental

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

Rafael Kramann et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Urology & Nephrology

Sonic Hedgehog Is a Novel Tubule-Derived Growth Factor for Interstitial Fibroblasts after Kidney Injury

Dong Zhou et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Review Urology & Nephrology

Macrophages promote renal fibrosis through direct and indirect mechanisms

David J. Nikolic-Paterson et al.

KIDNEY INTERNATIONAL SUPPLEMENTS (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Review Immunology

The immune system and kidney disease: basic concepts and clinical implications

Christian Kurts et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Urology & Nephrology

Neutralization of Tumor Necrosis Factor-Alpha Reduces Renal Fibrosis and Hypertension in Rats with Renal Failure

Frederick J. Therrien et al.

AMERICAN JOURNAL OF NEPHROLOGY (2012)

Article Rheumatology

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

Angelika Horn et al.

ARTHRITIS AND RHEUMATISM (2012)

Article Pathology

RNAscope A Novel in Situ RNA Analysis Platform for Formalin-Fixed, Paraffin-Embedded Tissues

Fay Wang et al.

JOURNAL OF MOLECULAR DIAGNOSTICS (2012)

Review Urology & Nephrology

The Renal Mononuclear Phagocytic System

Peter J. Nelson et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

Article Urology & Nephrology

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

Hong Ding et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

Review Pharmacology & Pharmacy

The Ubiquitin-Proteasome System (UPS) and the Mechanism of Action of Bortezomib

Boris Cvek et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

Article Urology & Nephrology

The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice

David A. Ferenbach et al.

KIDNEY INTERNATIONAL (2011)

Review Biotechnology & Applied Microbiology

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

Joon-Il Jun et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Multidisciplinary Sciences

Similar NF-κB Gene Signatures in TNF-α Treated Human Endothelial Cells and Breast Tumor Biopsies

Martine Perrot-Applanat et al.

PLOS ONE (2011)

Article Gastroenterology & Hepatology

Hedgehog Signaling Is Critical for Normal Liver Regeneration After Partial Hepatectomy in Mice

Begona Ochoa et al.

HEPATOLOGY (2010)

Article Cell Biology

Drosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation

Tiffiney R. Hartman et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Urology & Nephrology

The Ubiquitin-Like Protein FAT10 Mediates NF-κB Activation

Pengfei Gong et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Review Urology & Nephrology

NF-κB in Renal Inflammation

Ana Belen Sanz et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Biochemistry & Molecular Biology

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Carol Kilkenny et al.

PLOS BIOLOGY (2010)

Article Gastroenterology & Hepatology

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

Steve S. Choi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)

Article Medicine, Research & Experimental

Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury

Maarten F. Bijlsma et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2008)

Article Medicine, General & Internal

Prevalence of chronic kidney disease in the United States

Josef Coresh et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)

Article Biochemistry & Molecular Biology

A transcriptional profile of aging in the human kidney

GEJ Rodwell et al.

PLOS BIOLOGY (2004)