4.7 Article

Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report

Hrishikesh S. Kulkarni et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2022)

Article Toxicology

Identification of the function and regulatory network of circ_009773 in DNA damage induced by nanoparticles of neodymium oxide

Ling Liu et al.

Summary: This study analyzed the circRNA expression profile of human bronchial epithelial cells exposed to NPs-Nd2O3, identifying circ_009773 as a regulator of DNA damage caused by NPs-Nd2O3. A ceRNA network associated with circ_009773 was constructed, revealing key genes related to DNA damage and repair through module analysis.

TOXICOLOGY IN VITRO (2022)

Article Toxicology

Circular RNA circNIPBL promotes NNK-induced DNA damage in bronchial epithelial cells via the base excision repair pathway

Yufei Liu et al.

Summary: This study found that circular RNA circNIPBL promotes the DNA damage and cellular dysfunction induced by the tobacco carcinogen NNK through the base excision repair pathway. This finding further enhances our understanding of environmental carcinogenesis.

ARCHIVES OF TOXICOLOGY (2022)

Review Biochemistry & Molecular Biology

Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism

Qian Wang et al.

Summary: This systematic review provides a comprehensive overview of the biogenesis, biological characterization, relevant functions, and future studies of circular RNAs in the pathogenesis of pulmonary hypertension (PH).

ANIMAL MODELS AND EXPERIMENTAL MEDICINE (2022)

Article Environmental Sciences

LncRNA loc105377478 promotes NPs-Nd2O3-induced inflammation in human bronchial epithelial cells through the ADIPOR1/NF-κB axis

Feng Yu et al.

Summary: This study investigated the function and mechanism of long-chain non-coding RNAs in NPsNd(2)O(3)-induced airway inflammation, revealing that lncRNA loc105377478 promotes NF-kappa B activation by negatively regulating ADIPOR1 expression and upregulating IL-6 and IL-8 in 16HBE cells treated with NPs-Nd2O3.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Review Oncology

DNA Damage Repair Inhibitors-Combination Therapies

Gabriella Smith et al.

Summary: DDR is crucial for maintaining genomic integrity through intricate pathways that detect and repair DNA damage. The development of DDR inhibitors, particularly in combination therapies, shows promise in addressing unmet needs in cancer therapeutics. This review focuses on key DDR pathways and the current state of research on inhibitors in combination therapies.

CANCER JOURNAL (2021)

Review Genetics & Heredity

Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair

Nazanin Rahmanian et al.

Summary: The phosphorylation of histone variant H2AX and the formation of gamma H2AX are primary responses to DNA double-strand breaks, serving as robust and sensitive tools for diagnosing DNA damage and repair in pre-clinical drug discovery investigations. Gamma H2AX can also serve as a surrogate marker for drug-induced cytotoxicity, while recent advances in genomic research allow for its detection as a specific biomarker for quantitatively analyzing DNA damages and repair. The use of gamma H2AX as a biomarker shows promise in genotoxicity analyses and the monitoring and management of cancer diseases.

DNA REPAIR (2021)

Article Cell Biology

LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma

Zhen Guo et al.

Summary: Our study found that linc00312 is significantly down-regulated in NPC tissues and higher expression of linc00312 is associated with longer overall survival and better short-term radiotherapy efficacy. Overexpression of linc00312 increases NPC cells' sensitivity to ionizing radiation by hindering the DNA repair and cell cycle control mechanisms. DNA-PKcs was identified as the binding protein of linc00312, revealing a novel mechanism in the DNA damage response.

CELL DEATH & DISEASE (2021)

Article Biotechnology & Applied Microbiology

Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway

Yiqun Mo et al.

Summary: This study elucidated the mechanisms underlying Nano-Ni-induced cell malignant transformation; the combined effects of Nano-Ni-induced DNA damage and DNA repair defects through HIF-1 alpha/miR-210/Rad52 pathway likely contribute to Nano-Ni-induced genomic instability and ultimately cell transformation.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Multidisciplinary Sciences

Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons

Min-Min Lou et al.

Summary: This study demonstrates a neuron-specific role for Brain Specific DNA-damage Related lncRNA1 (BS-DRL1) in modulating DNA damage response (DDR) by interacting with HMGB1 in a cell-type specific manner. Knockout mice of BS-DRL1 show impaired motor function and purkinje cell degeneration, indicating a potential protective role of lncRNA against neurodegeneration.

NATURE COMMUNICATIONS (2021)

Review Medicine, Research & Experimental

Near-IR emissive rare-earth nanoparticles for guided surgery

Zhibei Qu et al.

THERANOSTICS (2020)

Article Biotechnology & Applied Microbiology

XRCC1 deficiency correlates with increased DNA damage and male infertility

Vertika Singh et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2019)

Review Cell Biology

DNA double-strand break repair-pathway choice in somatic mammalian cells

Ralph Scully et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Cytotoxicity, dose-enhancement and radiosensitization of glioblastoma cells with rare earth nanoparticles

Victor M. Lu et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Review Biochemistry & Molecular Biology

ROS and the DNA damage response in cancer

Upadhyayula Sai Srinivas et al.

REDOX BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Homologous recombination and the repair of DNA double-strand breaks

William Douglass Wright et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Size-dependent endocytosis and a dynamic-release model of nanoparticles

Ruihao Pan et al.

NANOSCALE (2018)

Article Multidisciplinary Sciences

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

Nausica Arnoult et al.

NATURE (2017)

Review Cell Biology

Non-homologous DNA end joining and alternative pathways to double-strand break repair

Howard H. Y. Chang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Cell Biology

The biogenesis and emerging roles of circular RNAs

Ling-Ling Chen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

MicroRNA-34a regulates cardiac ageing and function

Reinier A. Boon et al.

NATURE (2013)

Review Multidisciplinary Sciences

The DNA-damage response in human biology and disease

Stephen P. Jackson et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage

N Levy et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Materials Science, Multidisciplinary

Synthesis of Nd2O3 nanopowders by sol-gel auto-combustion and their catalytic esterification activity

W Yang et al.

MATERIALS CHEMISTRY AND PHYSICS (2004)

Review Biochemistry & Molecular Biology

The comet assay for DNA damage and repair - Principles, applications, and limitations

AR Collins

MOLECULAR BIOTECHNOLOGY (2004)

Article Materials Science, Multidisciplinary

The synthesis and the magnetic properties of Nd2O3-doped Ni-Mn ferrites nanoparticles

H Yang et al.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS (2004)

Review Environmental Sciences

Application of rare-earth elements in the agriculture of China and its environmental behavior in soil

X Pang et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2002)

Review Public, Environmental & Occupational Health

A critical evaluation of the scientific basis of the MAK Commission's new general threshold limit values for dust

JK McLaughlin et al.

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH (2001)