Association of genetic polymorphisms in detoxifying systems and urinary metal(loid) levels with excess body weight among Spanish children: A proof-of-concept study

Exposure to metal(loid)s during critical developmental windows could result in permanent damage to the target organ system, increasing susceptibility to disease later in life. In view of the fact that metals(loid)s have been shown to work as obesogens, the aim of the present case-control study was to evaluate the modification effect of exposure to metal (loid)s on the association between SNPs in genes involved in metal(loid) detoxification and excess body weight among children. A total of 134 Spanish children aged 6-12 years old were included (88 controls and 46 cases). Seven SNPs (GSTP1 rs1695 and rs1138272; GCLM rs3789453, ATP7B rs1061472, rs732774 and rs1801243; and ABCC2 rs1885301) were genotyped on GSA microchips, and ten metal(loid)s were analysed in urine samples through Inductively coupled plasma mass spectrometry (ICP-MS). Multivariable logistic regressions were conducted to assess the genetic and metal exposures' main association and interaction effects. GSTP1 rs1695 and ATP7B rs1061472

Automated summary

Exposure to metal(loid)s during critical developmental windows can cause permanent damage to organs, increasing disease vulnerability later in life. This study aimed to examine the effect of metal(loid) exposure on the association between gene variations related to metal(loid) detoxification and excess body weight in children. The study included 134 Spanish children, and genetic variations and metal(loid) levels in urine samples were analyzed. The results showed an interaction between the GSTP1 rs1695 and ATP7B rs1061472 variants and excess body weight.