The key role of proteostasis at mitochondria-associated endoplasmic reticulum membrane in vanadium-induced nephrotoxicity using a proteomic strategy

Article Environmental Sciences

Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health

Jing-Bo Liu et al.

Summary: Long-term exposure to GLY adversely affects BTB integrity and disrupts spermatogenesis.

ENVIRONMENT INTERNATIONAL (2022)

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Review Oncology

PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer

Ping Fan et al.

Summary: The discovery of 17 beta-estradiol-induced apoptosis is clinically relevant. PERK plays a critical role in inducing apoptosis, while IRE1 alpha and ATF6 are involved in the degradation of the PI3K/Akt/mTOR pathways. Additionally, PERK communicates with mitochondria to regulate oxidative stress at MAM and modulates the exchange of metabolites. This study highlights the mechanistic progress on how PERK acts as a multifunctional molecule in E-2-induced apoptosis.

MOLECULAR CANCER RESEARCH (2022)

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Article Medicine, Research & Experimental

Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKIIδ pathway in vitro and in vivo

Ziping Song et al.

Summary: This study elucidated the underlying mechanisms of sorafenib-induced cardiomyocyte damage. The researchers found that sorafenib caused mitochondrial Ca2+ overload, leading to cardiac necroptosis. The downregulation of MFN2 contributed to the excessive formation of MAMs and increased ER-mitochondria contact. Overexpression of MFN2 rescued sorafenib-induced cardiomyocyte necroptosis without affecting the anti-tumor effects.

THERANOSTICS (2022)

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Article Multidisciplinary Sciences

Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance

Hyo Jung Sim et al.

Summary: The ERAD complex plays a crucial role in cartilage formation and maintenance, and disruption of its function can lead to chondrodysplasia and cartilage destruction. Decreased ERAD gene expression is observed in damaged cartilage from OA patients.

SCIENCE ADVANCES (2022)

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Article Cell Biology

Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury

Baolin Niu et al.

Summary: APAP overdose can lead to ferroptosis, and protecting mitochondria can alleviate APAP-induced hepatocyte ferroptosis by restoring ceramide and cardiolipin content. Specifically, inhibiting VDAC1 oligomerization can protect hepatocytes from AILI damage by restoring ceramide and cardiolipin levels.

CELL BIOLOGY AND TOXICOLOGY (2022)

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Review Pharmacology & Pharmacy

Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases

Hui Mao et al.

Summary: This review introduces important proteins involved in the structure and functions of MAMs, and effectively summarizes their roles in the pathophysiology of various diseases.

BIOCHEMICAL PHARMACOLOGY (2022)

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Article Environmental Sciences

Activation of endoplasmic reticulum-mitochondria coupling drives copper-induced autophagy in duck renal tubular epithelial cells*

Xiaoyu Wang et al.

Summary: This study revealed the interaction between Mfn2-dependent MAM dynamics and autophagy in duck renal tubular epithelial cells under Cu exposure. Excessive Cu disrupted MAM integrity and activated autophagy.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Biochemistry & Molecular Biology

Endoplasmic reticulum-mitochondria coupling attenuates vanadium-induced apoptosis via IP3R in duck renal tubular epithelial cells

Junjun Peng et al.

Summary: Vanadium is essential for animal health but excessive levels can harm the ecosystem. This study investigates the effects of Vanadium on the ER-mitochondria coupling and apoptosis in duck kidney cells. The results suggest that Vanadium induces dysfunction in the ER-mitochondria coupling, leading to cell apoptosis. Inhibition of the ER-mitochondria coupling can attenuate Vanadium-induced apoptosis.

JOURNAL OF INORGANIC BIOCHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Balancing energy and protein homeostasis at ER-mitochondria contact sites

Amado Carreras-Sureda et al.

Summary: The endoplasmic reticulum (ER) is the largest organelle of the cell and is functionally connected to mitochondria through mitochondria-associated membranes. The signaling mechanisms between these two organelles play important roles in various diseases.

SCIENCE SIGNALING (2022)

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Article Cell Biology

The Adhesion GPCR VLGR1/ADGRV1 Regulates the Ca2+ Homeostasis at Mitochondria-Associated ER Membranes

Jacek Krzysko et al.

Summary: This study reveals the molecular and functional interaction between VLGR1 and MAMs, highlighting the essential role of VLGR1 in the regulation of Ca2+ homeostasis.

CELLS (2022)

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Article Cell Biology

Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes

Joshua J. Wang et al.

Summary: This study investigated the impact of diabetes on the retinal mitochondria-associated endoplasmic reticulum membrane (MAM) and its implication in the pathogenesis of diabetic retinopathy (DR). Proteomic analysis identified changes in MAM proteins involved in cell survival, inflammatory response, and disease-relevant signaling pathways in diabetic retinas.

CELLS (2022)

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Article Biochemistry & Molecular Biology

GRP75-faciliated Mitochondria-associated ER Membrane (MAM) Integrity controls Cisplatin-resistance in Ovarian Cancer Patients

Jing Li et al.

Summary: GRP75-faciliated MAM formation is enriched in cisplatin-resistant ovarian cancer cells. Diminishing MAM integrity by GRP75-deficiency reduces ER-to-mitochondrial Ca2+ transfer, accelerates mitochondrial dysfunction and ROS accumulation, and enhances cisplatin-triggered apoptotic cell death.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Review Engineering, Environmental

Vanadium in soil-plant system: Source, fate, toxicity, and bioremediation

Li Chen et al.

Summary: Vanadium(V) is an important industrial component, but can be toxic to organisms at high levels. It mainly accumulates in plant roots, with some plants accumulating high levels of V in aboveground tissues. Low levels of V have beneficial effects on plants, while excessive V can cause various harmful effects.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate Alleviates Vanadium-Induced Reduction of Antioxidant Capacity via Keap1-Nrf2-sMaf Pathway in the Liver, Kidney, and Ovary of Laying Hens

Yan Ma et al.

Summary: In this study, epigallocatechin-3-gallate (EGCG) was found to partially alleviate the reduction of antioxidant capacity induced by dietary vanadium (V) in the liver, kidney, and ovary of laying hens through the Keap1-Nrf2-sMaf pathway. EGCG supplementation completely prevented the V-induced reductions in egg production and quality, as well as serum hormone levels, while also reversing the V-induced increases in certain biochemical markers.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Article Agriculture, Multidisciplinary

Lycopene Ameliorates Di(2-ethylhexyl) Phthalate-Induced Pyroptosis in Spleen via Suppression of Classic Caspase-1/NLRP3 Pathway

Xue-Yan Dai et al.

Summary: The study demonstrated that lycopene could alleviate spleen injury induced by DEHP by inhibiting pyroptosis and the inflammatory response. This suggests that lycopene may be a new strategy to mitigate DEHP-induced spleen injury.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Environmental Sciences

H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway

Qianru Chi et al.

Summary: The study found that hydrogen sulfide (H2S) levels exceeded national standards in chicken houses in Harbin, posing a hazard to poultry health. By establishing H2S exposure and NaHS exposure models, the mechanisms of H2S toxicity on the immune system of chickens were revealed.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Review Cell Biology

Review: ER stress-induced cell death in osteoarthritic cartilage

Yvonne Rellmann et al.

Summary: Chondrocytes in cartilage are responsible for the synthesis and maintenance of the extracellular matrix, with various stresses leading to unfolded protein response and potential cell death. Targeting ER stress in chondrocytes may be a promising approach for future osteoarthritis therapy.

CELLULAR SIGNALLING (2021)

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Article Environmental Sciences

Endoplasmic reticulum stress aggravates copper-induced apoptosis via the PERK/ATF4/CHOP signaling pathway in duck renal tubular epithelial cells

Xiaoyu Wang et al.

Summary: Excessive copper can trigger ER stress and apoptosis in duck renal tubular epithelial cells via the PERK/ATF4/CHOP signaling pathway. Treatment with PERK inhibitor can ameliorate the adverse effects caused by copper exposure.

ENVIRONMENTAL POLLUTION (2021)

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Article Oncology

Revealing functional insights into ER proteostasis through proteomics and interactomics

Madison T. Wright et al.

Summary: The endoplasmic reticulum (ER) plays a crucial role in processing the human proteome, with mass spectrometry technology being key in understanding protein quality control mechanisms. There are still unexplored areas in ER proteostasis where mass spectrometry can be utilized to expand our understanding of protein quality control processes in diverse diseases.

EXPERIMENTAL CELL RESEARCH (2021)

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Review Cardiac & Cardiovascular Systems

Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

Jun Ren et al.

Summary: This review summarizes the role of endoplasmic reticulum stress and protein response in cardiovascular diseases, discussing potential therapeutic strategies for restoring ER proteostasis.

NATURE REVIEWS CARDIOLOGY (2021)

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Review Cell Biology

ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD

Maurizio Molinari

Summary: ER-phagy is a process of clearing ER portions through a set of regulatory proteins called ER-phagy receptors, promoting ER fragmentation and lysosomal clearance. ER-phagy responses ensure the clearance of unnecessary, nonfunctional, or abnormal ER portions in cooperation with unfolded protein responses (UPRs) and ER-associated degradation (ERAD) to maintain ER function and homeostasis.

DEVELOPMENTAL CELL (2021)

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Article Biochemistry & Molecular Biology

Endoplasmic Reticulum Subproteome Analysis Reveals Underlying Defense Mechanisms of Wheat Seedling Leaves under Salt Stress

Junwei Zhang et al.

Summary: Salt stress significantly inhibits wheat seedling growth by affecting the accumulation of proteins in the endoplasmic reticulum.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

On the Role of the Immunoproteasome in Protein Homeostasis

Michael Basler et al.

Summary: The immunoproteasome is a special type of proteasome induced under inflammatory conditions, contributing to protein homeostasis in cells and involved in immune response, T cell expansion, and inflammatory diseases. Targeting the immunoproteasome has shown therapeutic effectiveness in cancer, autoimmune diseases, and transplantation in preclinical animal models.

CELLS (2021)

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Review Neurosciences

Connection Lost, MAM: Errors in ER-Mitochondria Connections in Neurodegenerative Diseases

Ashu Johri et al.

Summary: Mitochondria associated membranes (MAMs) are important structures that physically and biochemically connect mitochondria with endoplasmic reticulum, playing a crucial role in cellular functions such as Ca2+ homeostasis, proteostasis, mitochondrial bioenergetics, movement, and mitophagy. The increasing number of disease-related proteins and genes associated with MAMs suggests their potential involvement in neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease. MAMs have recently gained attention as modulators for ER-mitochondria communication and function, showing promise for future therapeutic discoveries in this rapidly developing field.

BRAIN SCIENCES (2021)

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Article Veterinary Sciences

Vanadium Induces Oxidative Stress and Mitochondrial Quality Control Disorder in the Heart of Ducks

Zhiwei Xiong et al.

Summary: The study showed that excessive vanadium could induce various pathological changes in duck cardiac cells, leading to oxidative stress and dysfunction of mitochondrial quality control (MQC).

FRONTIERS IN VETERINARY SCIENCE (2021)

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Review Cell Biology

Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

Md. Sahab Uddin et al.

Summary: Alzheimer's disease is characterized by the accumulation of misfolded proteins due to changes in protein homeostasis, possibly stemming from endoplasmic reticulum stress. The unfolded protein response is a critical signaling cascade that helps reduce misfolded proteins, but age-related changes in ER chaperones and enzymes can disrupt this process. The accumulation of misfolded proteins in AD, caused by sustained cellular stress, leads to neurodegeneration and neuronal death.

AGEING RESEARCH REVIEWS (2021)

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Article Biochemistry & Molecular Biology

N-glycan processing selects ERAD-resistant misfolded proteins for ER-to-lysosome-associated degradation

Ilaria Fregno et al.

Summary: This study demonstrates that mannose and glucose processing of N-glycans are crucial events in targeting misfolded proteins to ERAD and ERLAD in eukaryotic cells. These events regulate protein quality control in eukaryotic cells.

EMBO JOURNAL (2021)

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Article Cell Biology

Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells

Camila Lopez-Crisosto et al.

Summary: Subcellular organelles communicate and coordinate responses, with the physical coupling of the endoplasmic reticulum (ER) and mitochondria playing a key role in boosting mitochondrial metabolic activity. The mitochondrial unfolded protein response (mtUPR) is activated by unfolded proteins, leading to transcriptional responses aimed at restoring protein homeostasis. Increase in mitochondrial-ER coupling during mitochondrial stress can potentiate mitochondrial metabolic activity as a part of protective response.

CELL DEATH & DISEASE (2021)

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Article Environmental Sciences

Establishment of geochemical baseline and multiple assessment of vanadium pollution in sediment cores from the two cascade reservoirs, North China

Jiankang Wang et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2020)

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Review Clinical Neurology

Mini review-vanadium-induced neurotoxicity and possible targets

Madhuri Ramji Jaiswal et al.

NEUROLOGICAL SCIENCES (2020)

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Review Cell Biology

Protective Effects of Dietary Antioxidants against Vanadium-Induced Toxicity: A Review

Iwona Zwolak

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Agriculture, Dairy & Animal Science

Research Note: Effects of riboflavin on reproductive performance and antioxidant status of duck breeders

B. Zhang et al.

POULTRY SCIENCE (2020)

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Article Multidisciplinary Sciences

Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes

Zhangsen Zhou et al.

SCIENCE (2020)

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Article Genetics & Heredity

Loss of ERAD bridging factor UBX2 modulates lipid metabolism and leads to ER stress-associated apoptosis during cadmium toxicity in Saccharomyces cerevisiae

Selvaraj Rajakumar et al.

CURRENT GENETICS (2020)

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Review Biochemistry & Molecular Biology

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends

Agnieszka Scibior et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

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Article Environmental Sciences

Geochemical baseline establishment, environmental impact and health risk assessment of vanadium in lake sediments, China

Yang Zhou et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

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Article Multidisciplinary Sciences

Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy

Nathalie Bernard-Marissal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Pharmacology & Pharmacy

Oxidative Stress as a Mechanism Involved in Kidney Damage After Subchronic Exposure to Vanadium Inhalation and Oral Sweetened Beverages in a Mouse Model

Maribel Espinosa-Zurutuza et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2018)

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Review Biochemistry & Molecular Biology

Vanadium in Biosphere and Its Role in Biological Processes

Deepika Tripathi et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2018)

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Review Cell Biology

Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death

Tomas Gutierrez et al.

CELL CALCIUM (2018)

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Review Cell Biology

Mitochondria-associated membranes in aging and senescence: structure, function, and dynamics

Justyna Janikiewicz et al.

CELL DEATH & DISEASE (2018)

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Review Multidisciplinary Sciences

Here, there, and everywhere: The importance of ER membrane contact sites

Haoxi Wu et al.

SCIENCE (2018)

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Article Biochemistry & Molecular Biology

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

Zecai Zhang et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2017)

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Article Biochemistry & Molecular Biology

High-Fat Diet Increased Renal and Hepatic Oxidative Stress Induced by Vanadium of Wistar Rat

J. P. Wang et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2016)

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Review Cell Biology

Structure and function of ER membrane contact sites with other organelles

Melissa J. Phillips et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

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Article Environmental Sciences

Influence of dissolved organic matter on dissolved vanadium speciation in the Churchill River estuary (Manitoba, Canada)

Yong Xiang Shi et al.

CHEMOSPHERE (2016)

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Article Multidisciplinary Sciences

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

Samantha C. Lewis et al.

SCIENCE (2016)

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Article Environmental Sciences

Mitochondria dysfunction by pro-oxidant vanadium: Ex vivo assessment of individual susceptibility

Giuseppa Visalli et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)

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Article Oncology

Vanadium toxicity in the thymic development

Wei Cui et al.

ONCOTARGET (2015)

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Article Engineering, Environmental

Sphagnum Mosses from 21 Ombrotrophic Bogs in the Athabasca Bituminous Sands Region Show No Significant Atmospheric Contamination of Heavy Metals

William Shotyk et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

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Article Multidisciplinary Sciences

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

Shengyi Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Biochemistry & Molecular Biology

Heavy Metals and Metalloids As a Cause for Protein Misfolding and Aggregation

Markus J. Tamas et al.

BIOMOLECULES (2014)

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Article Biochemistry & Molecular Biology

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

Roberto Bravo et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

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Article Cell Biology

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

Roberto Bravo et al.

JOURNAL OF CELL SCIENCE (2011)

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Review Pharmacology & Pharmacy

Advances in metal-induced oxidative stress and human disease

Klaudia Jomova et al.

TOXICOLOGY (2011)

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Article Biochemical Research Methods

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

Mariusz R. Wieckowski et al.

NATURE PROTOCOLS (2009)

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Article Multidisciplinary Sciences

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

T Nakagawa et al.

NATURE (2000)

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The key role of proteostasis at mitochondria-associated endoplasmic reticulum membrane in vanadium-induced nephrotoxicity using a proteomic strategy

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