☆ 4.7 Editorial Material

Electrolyser design controls position-divergent C-H carboxylation

SCIENCE CHINA-CHEMISTRY (2023)

Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations

Guo-Quan Sun et al.

Summary: Pyridines and related N-heteroarenes are commonly found in pharmaceuticals, agrochemicals and other biologically active compounds. Site-selective C-H functionalization could directly produce these medicinally active products. In this study, an electrochemical strategy using CO2 was developed for the direct carboxylation of pyridines. The choice of the electrolysis setup led to divergent site selectivity: a divided electrochemical cell resulted in C5 carboxylation, while an undivided cell promoted C4 carboxylation. The undivided-cell reaction was proposed to operate through a paired-electrolysis mechanism.

NATURE (2023)

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Review Chemistry, Multidisciplinary

Radical Carboxylative Cyclizations and Carboxylations with CO2

Jian-Heng Ye et al.

Summary: Carbon dioxide is a valuable carbon resource in organic synthesis, but its utilization is challenging due to stability and inertness. Researchers have developed radical-type carboxylations and cyclizations using visible-light photoredox catalysis and copper catalysis. These strategies have expanded the scope of CO2 transformations and provided new methods for selective organic synthesis.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

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Review Chemistry, Multidisciplinary