Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and functional networks. We identified 80 associated genomic loci (P < 6.09 x 10-10) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.

Automated summary

Cardiovascular health is closely connected to cognitive and mental health. Through the use of multiorgan magnetic resonance imaging (MRI) data, we identified the genetic links between heart and brain systems. Our study revealed numerous associations between heart MRI traits and brain morphology, white matter structure, and functional networks. The shared genetic influences between cardiovascular and brain disorders were also observed. Our findings suggest a causal contribution of heart conditions to brain disorders, providing a comprehensive understanding of human health.