A super Sonic circadian synchronizer

Article Multidisciplinary Sciences

Rhythmic cilia changes support SCN neuron coherence in circadian clock

Hai-Qing Tu et al.

Summary: The primary cilia in neuromedin S-producing (NMS) neurons are crucial for intercellular coupling and maintaining the robustness of the internal clock in the suprachiasmatic nucleus (SCN) of mice. Genetic ablation of ciliogenesis in NMS neurons leads to rapid phase shifts of the internal clock under jet-lag conditions and loss of coherence in the circadian rhythms of individual neurons. The cilia-Shh signaling pathway plays a role in intercellular coupling by driving oscillations of Sonic Hedgehog (Shh) signaling and clock gene expression.

SCIENCE (2023)

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Review Cell Biology

Intraflagellar Transport Proteins as Regulators of Primary Cilia Length

Wei Wang et al.

Summary: This article discusses the functions of primary cilia as important organelles and their significance in ciliary-related diseases; it also explores the mechanisms and factors involved in maintaining optimal cilia length, as well as the roles of IFT in cilia assembly/disassembly processes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Medicine, Research & Experimental

Circadian disruption and human health

Anna B. Fishbein et al.

Summary: Circadian disruption can increase disease severity and risk, but utilizing research findings in circadian biology to enhance health offers a unique opportunity for personalized medicine and societal well-being.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Cell Biology