相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer
Chewei Anderson Chang et al.
CANCER DISCOVERY (2022)
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
Ronan Chaligne et al.
NATURE GENETICS (2021)
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer
Andrea Sacchetti et al.
ELIFE (2021)
A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML
Michael A. Koldobskiy et al.
EPIGENETICS (2020)
Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance
Andriy Marusyk et al.
CANCER CELL (2020)
State-Transition Analysis of Time-Sequential Gene Expression Identifies Critical Points That Predict Development of Acute Myeloid Leukemia
Russell C. Rockne et al.
CANCER RESEARCH (2020)
A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells
Shubham Tripathi et al.
PLOS COMPUTATIONAL BIOLOGY (2020)
Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer
Li-Yun Ding et al.
CLINICAL EPIGENETICS (2020)
RUNX1 and CBFp-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development
Tao Zhen et al.
BLOOD (2020)
Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer
Sarah E. Johnstone et al.
CELL (2020)
Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells
Zohar Meir et al.
NATURE GENETICS (2020)
A single-cell survey of cellular hierarchy in acute myeloid leukemia
Junqing Wu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML
Sheng Li et al.
CANCER DISCOVERY (2020)
Tumour heterogeneity and the evolutionary trade-offs of cancer
Jean Hausser et al.
NATURE REVIEWS CANCER (2020)
The genetic changes of Wilms tumour
Taryn Dora Treger et al.
NATURE REVIEWS NEPHROLOGY (2019)
Challenges in measuring and understanding biological noise
Nils Eling et al.
NATURE REVIEWS GENETICS (2019)
Reprogrammable CRISPR/dCas9-based recruitment of DNMT1 for site-specific DNA demethylation and gene regulation
Anrui Lu et al.
CELL DISCOVERY (2019)
Ranking genomic features using an information-theoretic measure of epigenetic discordance
Garrett Jenkinson et al.
BMC BIOINFORMATICS (2019)
Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
JinSeok Park et al.
NATURE COMMUNICATIONS (2019)
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
Alexander M. Tsankov et al.
DEVELOPMENT (2019)
Tumor diversity and the trade-off between universal cancer tasks
Jean Hausser et al.
NATURE COMMUNICATIONS (2019)
p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer
Piotr T. Filipczak et al.
CANCER RESEARCH (2019)
Single-cell and single-molecule epigenomics to uncover genome regulation at unprecedented resolution
Efrat Shema et al.
NATURE GENETICS (2019)
Accumulation of genetic and epigenetic alterations in normal cells and cancer risk
Hideyuki Takeshima et al.
NPJ PRECISION ONCOLOGY (2019)
Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome
Weiyan Chen et al.
COMMUNICATIONS BIOLOGY (2019)
Rho GTPase signaling complexes in cell migration and invasion
Campbell D. Lawson et al.
JOURNAL OF CELL BIOLOGY (2018)
Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer
Yating Cheng et al.
PLOS ONE (2018)
Arid1a restrains Kras-dependent changes in acinar cell identity
Geulah Livshits et al.
ELIFE (2018)
Geometry of Gene Expression Space of Wilms' Tumors From Human Patients
Ariel Trink et al.
NEOPLASIA (2018)
A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
Kiran G. Vanaja et al.
MOLECULAR CELL (2018)
Overproduction of IGF-2 drives a subset of colorectal cancer cells, which specifically respond to an anti-IGF therapeutic antibody and combination therapies
H. Zhong et al.
ONCOGENE (2017)
p53 is essential for DNA methylation homeostasis in naive embryonic stem cells, and its loss promotes clonal heterogeneity
Ayala Tovy et al.
GENES & DEVELOPMENT (2017)
Potential energy landscapes identify the information-theoretic nature of the epigenome
Garrett Jenkinson et al.
NATURE GENETICS (2017)
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis
Oliver G. McDonald et al.
NATURE GENETICS (2017)
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
Peter Storz
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)
Fundamental trade-offs between information flow in single cells and cellular populations
Ryan Suderman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Epigenetic Drift Is a Determinant of Mammalian Lifespan
Andrew R. Mendelsohn et al.
REJUVENATION RESEARCH (2017)
Single-cell epigenomics: Recording the past and predicting the future
Gavin Kelsey et al.
SCIENCE (2017)
Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome
Andrew E. Teschendorff et al.
NATURE COMMUNICATIONS (2017)
The p53 protein plays a central role in the mechanism of action of epigentic drugs that alter the methylation of cytosine residues in DNA
Arnold J. Levine
ONCOTARGET (2017)
A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns
William R. Holmes et al.
PLOS COMPUTATIONAL BIOLOGY (2017)
Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma
E. Georg Luebeck et al.
CLINICAL EPIGENETICS (2017)
Modeling the Attractor Landscape of Disease Progression: a Network-Based Approach
Atefeh Taherian Fard et al.
FRONTIERS IN GENETICS (2017)
Phenotypic Plasticity and Cell Fate Decisions in Cancer: Insights from Dynamical Systems Theory
Dongya Jia et al.
CANCERS (2017)
Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence
Veronique Giroux et al.
NATURE REVIEWS CANCER (2017)
Quantification of tumour evolution and heterogeneity via Bayesian epiallele detection
James E. Barrett et al.
BMC BIOINFORMATICS (2017)
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
Brian B. Liau et al.
CELL STEM CELL (2017)
Stochastic epigenetic outliers can define field defects in cancer
Andrew E. Teschendorff et al.
BMC BIOINFORMATICS (2016)
Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach
Feixiong Cheng et al.
BMC SYSTEMS BIOLOGY (2016)
KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis
Daoyan Wei et al.
CANCER CELL (2016)
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
Sheng Li et al.
NATURE MEDICINE (2016)
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
Andrew P. Feinberg et al.
NATURE REVIEWS GENETICS (2016)
Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape
Qin Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis
David Ellison et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Epigenetic drift, epigenetic clocks and cancer risk
Shijie C. Zheng et al.
EPIGENOMICS (2016)
Design and Analysis of Single-Cell Sequencing Experiments
Dominic Gruen et al.
CELL (2015)
Limits on information transduction through amplitude and frequency regulation of transcription factor activity
Anders S. Hansen et al.
ELIFE (2015)
Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia
Dan A. Landau et al.
CANCER CELL (2014)
Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation
Kotaro Ohnishi et al.
CELL (2014)
Cellular noise and information transmission
Andre Levchenko et al.
CURRENT OPINION IN BIOTECHNOLOGY (2014)
Dynamic Heterogeneity and DNA Methylation in Embryonic Stem Cells
Zakary S. Singer et al.
MOLECULAR CELL (2014)
Large conserved domains of low DNA methylation maintained by Dnmt3a
Mira Jeong et al.
NATURE GENETICS (2014)
Barrett's Esophagus
Stuart J. Spechler et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Next-generation sequencing of endoscopic biopsies identifies ARID1A as a tumor-suppressor gene in Barrett's esophagus
M. M. Streppel et al.
ONCOGENE (2014)
Landscape and flux reveal a new global view and physical quantification of mammalian cell cycle
Chunhe Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Accurate information transmission through dynamic biochemical signaling networks
Jangir Selimkhanov et al.
SCIENCE (2014)
DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia
Raajit Rampal et al.
CELL REPORTS (2014)
Lessons from the Cancer Genome
Levi A. Garraway et al.
CELL (2013)
Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming
Yawei Gao et al.
CELL STEM CELL (2013)
Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
Andrew E. Teschendorff et al.
HUMAN MOLECULAR GENETICS (2013)
Perspective: Stochastic algorithms for chemical kinetics
Daniel T. Gillespie et al.
JOURNAL OF CHEMICAL PHYSICS (2013)
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency
Yael Costa et al.
NATURE (2013)
Robustness and Compensation of Information Transmission of Signaling Pathways
Shinsuke Uda et al.
SCIENCE (2013)
DNA methylation age of human tissues and cell types
Steve Horvath
GENOME BIOLOGY (2013)
Regulated Noise in the Epigenetic Landscape of Development and Disease
Elisabet Pujadas et al.
CELL (2012)
EMT and Dissemination Precede Pancreatic Tumor Formation
Andrew D. Rhim et al.
CELL (2012)
Barrett's esophagus and esophageal cancer: An overview
Vincenza Conteduca et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2012)
Quasi-potential landscape in complex multi-stable systems
Joseph Xu Zhou et al.
JOURNAL OF THE ROYAL SOCIETY INTERFACE (2012)
Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2
Claudia A. Doege et al.
NATURE (2012)
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
Benjamin P. Berman et al.
NATURE GENETICS (2012)
Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues
Gilad Landan et al.
NATURE GENETICS (2012)
The application of information theory to biochemical signaling systems
Alex Rhee et al.
PHYSICAL BIOLOGY (2012)
How Information Theory Handles Cell Signaling and Uncertainty
Matthew D. Brennan et al.
SCIENCE (2012)
Differential network entropy reveals cancer system hallmarks
James West et al.
SCIENTIFIC REPORTS (2012)
Statistical analysis of the cancer cell's molecular entropy using high-throughput data
Wessel N. van Wieringen et al.
BIOINFORMATICS (2011)
Cellular Decision Making and Biological Noise: From Microbes to Mammals
Gabor Balazsi et al.
CELL (2011)
Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
Piyush B. Gupta et al.
CELL (2011)
CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype
Rita Barros et al.
GUT (2011)
Pancreatic ductal cells in development, regeneration, and neoplasia
Maximilian Reichert et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Increased methylation variation in epigenetic domains across cancer types
Kasper Daniel Hansen et al.
NATURE GENETICS (2011)
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
Oliver G. McDonald et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Genome-wide quantitative assessment of variation in DNA methylation patterns
Hehuang Xie et al.
NUCLEIC ACIDS RESEARCH (2011)
Quantifying the Waddington landscape and biological paths for development and differentiation
Jin Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Information Transduction Capacity of Noisy Biochemical Signaling Networks
Raymond Cheong et al.
SCIENCE (2011)
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
Sreenath V. Sharma et al.
CELL (2010)
Widespread and tissue specific age-related DNA methylation changes in mice
Shinji Maegawa et al.
GENOME RESEARCH (2010)
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
Joseph H. Taube et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Stochastic approaches in systems biology
Mukhtar Ullah et al.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2010)
Nanog Is the Gateway to the Pluripotent Ground State
Jose Silva et al.
CELL (2009)
System-level feedbacks control cell cycle progression
Orsolya Kapuy et al.
FEBS LETTERS (2009)
Moving AHEAD with an international human epigenome project
Peter A. Jones et al.
NATURE (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
BCL-2 in the crosshairs: tipping the balance of life and death
L. D. Walensky
CELL DEATH AND DIFFERENTIATION (2006)