4.1 Article

Solvent-Free Reaction of 3,6-Diaryl-1,2,4-triazine-5-carbonitriles with 2-Amino-4-aryloxazoles

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Summary: The study investigates the interactions of 5,6-diaryl-3-(quinolin-2-yl)-1,2,4-triazines with arynes. 2-(3,4-Diarylisoqunolin-1-yl)quinolines are obtained in up to 65% yield through the inverse-demand Diels-Alder reaction between 5,6-diaryl-3-(quinolone-2-yl)-1,2,4-triazines and benzyne, generated in situ.

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Summary: This study tested various conditions for the inverse electron-demand aza-Diels-Alder reaction in order to obtain 4,5-diaryl-3-hydroxy-2,2'-bipyridine-6-carbonitriles from the series of 5-aryl-3-(2-pyridyl)-1,2,4-triazine-5-carbonitriles and 2-amino-4-aryloxazoles. Heating in 1,2-dichlorobenzene or under solvent-free conditions were found to be the most effective.

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