相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article
Biochemistry & Molecular Biology
Aref Hosseini et al.
Summary: Neutrophil extracellular traps (NETs) and oxidative stress play important roles in the immune defense against pathogens. However, impaired clearance of NETs in the lungs of COVID-19 patients may contribute to severe respiratory syndrome infection. Through RNA sequencing (RNA-seq) and immunofluorescence and immunohistochemistry methods, the study identified increased oxidative stress and viral-related signaling pathways in COVID-19 patients' lungs. Excess neutrophil infiltration and NET formation, with oxidized extracellular DNA co-localizing with myeloperoxidase (MPO), were observed. The lipid peroxidation marker 4-hydroxynonenal (4-HNE) showed high colocalization with NETs and correlated with lung neutrophil infiltration, suggesting its potential as a marker for identifying NETs and disease severity. Local inhalation therapy to reduce lipid oxidation and NETs may benefit severely infected patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Myrtani Pieri et al.
Summary: This critical review explores the relationship between COVID-19 and CVD, focusing on cardio-specific miRNAs and their association with various CVDs. Limited research suggests that changes in expression levels of COVID-19-related miRNAs may be linked to CVDs. Further research on the relationship between SARS-CoV-2, CVDs, and miRNAs will enhance our understanding and may lead to the use of these miRNAs as biomarkers or therapeutic targets for both pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Leire Moya et al.
Summary: COVID-19 has caused significant impacts globally, infecting over 112 million people and causing more than 2.5 million deaths. In Europe, Spain and Italy had a high number of COVID-19 related deaths, while many infected individuals did not develop severe illness. Researchers speculated that unique genomic characteristics in these populations could contribute to a poorer prognosis.
Article
Pharmacology & Pharmacy
Jessica Gambardella et al.
Summary: We hypothesized that exosomal microRNAs may play a role in the development of thromboembolic complications in COVID-19. We isolated circulating exosomes from COVID-19 patients and categorized them based on D-dimer levels. We found that exosomal miR-145 and miR-885 were significantly correlated with D-dimer levels. Furthermore, human endothelial cells treated with serum from COVID-19 patients showed reduced release of miR-145 and miR-885, increased apoptosis, and impaired angiogenetic properties compared to cells treated with non-COVID-19 serum.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Immunology
Chengyan Zhang et al.
Summary: This study used transcriptomic and single-cell analysis to detect common molecular and cellular intersections between COVID-19 and IBD, finding common immune responses and suggesting that COVID-19 may promote the progression of IBD through cytokine storms. These findings help understand the linkage between COVID-19 and IBD and provide potential therapeutic methods.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Magloire Pandoua Nekoua et al.
Summary: Viral infections have long been associated with physiological and pathological changes in the endocrine system. The current pandemic of COVID-19 has revealed numerous endocrine complications, highlighting the need to better understand the impact of viral infections on the endocrine system. Several viruses can directly damage endocrine cells or indirectly disrupt the system through the activation of the host antiviral immune response, leading to inflammation or organ-specific autoimmunity. Furthermore, endocrine disorders can also impact susceptibility to viral infections due to the immunoregulatory functions of endocrine hormones.
Review
Cardiac & Cardiovascular Systems
Lauren M. Arguinchona et al.
Summary: As 2023 nears, the COVID-19 pandemic continues to claim millions of lives. While vaccines have been vital, there are limited effective medications available for prevention and treatment of COVID-19 in breakthrough cases or in individuals who are unvaccinated or immunocompromised. The activation of TGF-beta 1 protein may exacerbate clotting, cause immune dysregulation, and contribute to tissue fibrosis in COVID-19.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Cristina Capatina et al.
Summary: There is increasing interest in understanding how COVID-19 affects the endocrine system, specifically the pituitary gland. Studies have shown that COVID-19 can lead to various pituitary dysfunctions, such as hypopituitarism, pituitary apoplexy, and hypophysitis. Patients with pre-existing pituitary conditions, such as acromegaly, Cushing's disease, and hypopituitarism, may have an increased risk of complications with COVID-19. Further research is still being conducted to fully understand the impact of COVID-19 on pituitary function.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Charlotte Steenblock et al.
Summary: The SARS-CoV-2 virus can infect various tissues including endocrine organs, leading to organ damage or dysfunction. The main receptor ACE2 is expressed in cells of the endocrine system, and the virus has been found in post-mortem samples from COVID-19 patients. The exact mechanisms are not fully understood and further research is needed. Additionally, endocrine diseases may impact the severity of COVID-19, highlighting the importance of reducing their prevalence or improving treatment in the future.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Genetics & Heredity
Kaifee Arman et al.
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, known as COVID-19, has entered the human population, causing loss of life and a significant economic crisis. Understanding the characteristics and interactions of this virus with human host cells is crucial. Non-coding RNAs, such as micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been found to play significant roles in regulating gene expression in various cancers and viral diseases. In this review, we discuss the role of miRNAs and lncRNAs in regulating the immune response against SARS-CoV-2, their mechanisms of action, and their potential as therapeutic targets.
Article
Immunology
Asieh Asadpour-Behzadi et al.
Summary: The expression levels of T helper subsets-related transcription factors, Th17 products, and microRNAs were evaluated in Iranian hospitalized patients with severe COVID-19. The results showed increased levels of ROR gamma t and FOXP3 mRNA, and decreased levels of IL-17A, IL-8, and CCL20 mRNA in SARS-CoV-2 infected patients. MiR-194 was found to have correlations with ROR gamma t and IL-17A expression in healthy controls.
News Item
Infectious Diseases
Sharmila Devi
LANCET INFECTIOUS DISEASES
(2023)
Article
Physiology
Carla Roberta Peachazepi Moraes et al.
Summary: In this study, the researchers found that the serum from COVID-19 patients can disrupt the endothelial barrier integrity in cell monolayers. They also observed that the levels of soluble Tie2 were increased and soluble VE-cadherin were decreased in these patients compared to healthy individuals. Furthermore, the magnitude of this disruption was proportional to disease severity and levels of VEGF-A and Ang-2. These findings provide important insights into the pathogenesis of acute lung injury in COVID-19 and may contribute to the development of new biomarkers and therapeutic targets.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cell Biology
Albert Leng et al.
Summary: The development of long-term symptoms of COVID-19, known as long COVID or PASC, can involve persistent neurological complications in up to one third of patients. These complications include fatigue, brain fog, headaches, cognitive impairment, and neuropsychiatric symptoms. The underlying pathological mechanisms behind these symptoms are still unclear, but hypotheses suggest involvement of nervous system and systemic factors such as viral persistence, abnormal immune response, and endothelial dysfunction. Current therapeutic approaches focus on antivirals, inflammation reduction, and olfactory epithelium regeneration.
Review
Cell Biology
Tristram A. J. Ryan et al.
Summary: Microbial detection by innate immune cells induces the expression of type I interferons (IFNs), which play a crucial role in coordinating innate immune responses. However, type I IFNs also interact with coagulation-related factors and modulate vascular function and thrombosis. This interaction may contribute to the increased risk of thrombotic complications in infection and type I interferonopathies. Pharmacological regulation of type I IFN signalling could be a potential therapeutic approach for treating aberrant coagulation and thrombosis.
Article
Cell Biology
Carla Petrella et al.
Summary: This pilot study aimed to investigate the impact of COVID-19 on brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9, and neurofilament light chain (NFL) pathways in aged men. The results showed disrupted serum BDNF, NFL, and MMP-2 presence in severe or fatal COVID-19 cases, along with changes in routine blood parameters. The ratio of MMPs (2 and 9) to BDNF and NFL was found to be a useful tool for predicting fatal outcomes of COVID-19.
Review
Biochemistry & Molecular Biology
Irina Gilyazova et al.
Summary: COVID-19 is a severe acute illness caused by the novel coronavirus infection, which can lead to respiratory distress syndrome. It is a global problem that requires in-depth study of its pathogenesis and molecular changes in severe cases. Among the factors involved, viral and host non-coding RNAs, particularly microRNAs and long non-coding RNAs, play important roles. Furthermore, COVID-19 not only affects the respiratory system but also the liver, kidneys, and nervous system.
NON-CODING RNA RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Samuel Reyes-Long et al.
Summary: The ongoing COVID-19 pandemic has resulted in over 6.7 million deaths and a large percentage of survivors experiencing long COVID, characterized by chronic symptoms lasting at least 6 months. Common symptoms include headache, joint pain, fatigue, and myalgia. This systematic review evaluated the prevalence of pain-like symptoms in long COVID patients and the role of miRNAs in COVID-19, suggesting potential molecular pathways associated with chronic pain and fatigue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Thais G. Moreira et al.
Summary: The nasal administration of a fully human anti-CD3 monoclonal antibody (Foralumab) in COVID-19 patients reduces lung inflammation and serum inflammatory protein levels, modulates T cell types, and improves the disease outcome by affecting specific gene expression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cardiac & Cardiovascular Systems
Clemens Gutmann et al.
Summary: Research shows that circulating miRNAs from different tissue origins play a crucial role in the severity and prognosis of COVID-19, with miR-133a and miR-122 potentially associated with the risk of mortality in patients.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
S. M. Akula et al.
Summary: The role of circulating miRNAs as biomarkers for COVID-19 remains uncertain. However, analysis of circulating miRNA profiles in COVID-19 patients revealed significant changes, with miR-150-5p potentially playing a crucial role in SARS-CoV-2 infection. Further investigation into the mechanism by which COVID-19-induced changes in miR-150-5p levels may promote SARS-CoV-2 infection is warranted.
Review
Virology
Sujay Paul et al.
Summary: This article explores the clinical relevance and biological roles of miRNAs in COVID-19. It suggests that miRNAs could serve as potential biomarkers and therapeutic targets for this disease, aiding in diagnosis and treatment.
Article
Immunology
Asier Fernandez-Pato et al.
Summary: COVID-19 deeply affects the plasma miRNome from an early stage, indicating that miRNAs can serve as valuable early predictors of severity and mortality.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Genetics & Heredity
Ales Eichmeier et al.
Summary: The use of high-throughput small RNA sequencing is a well-established technique for uncovering miRNAs in various tissues. In this study, we compared the miRNA profiles of SARS-CoV-2 positive and negative RNA samples extracted from human nasopharynx tissue samples. We identified differentially expressed miRNAs, with miR-21 showing the most significant differential expression and likely having a close association with the presence of SARS-CoV-2 in nasopharynx tissues. These findings contribute to our understanding of the role of miRNAs in SARS-CoV-2 pathogenesis and may be important for understanding disease symptom development in humans.
Article
Immunology
Pedro Martinez-Fleta et al.
Summary: This study compared plasma miRNA and cytokine profiles between COVID-19 and other community-acquired pneumonias (CAP), revealing 15 dysregulated miRNAs and differential cytokine signatures. These findings provide new insights into the etiopathological mechanisms of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Reut Kassif-Lerner et al.
Summary: This study investigated circulating miRNAs in hospitalized COVID-19 patients and found that miR-155 expression was lower in mild and severe patients compared to healthy individuals. The researchers also identified miR-155 as a good predictor of COVID-19 mortality and suggested testing miR-155 levels upon admission to improve patient care.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pathology
Jeffrey Laurence et al.
Summary: This study identified tissue correlates of the clinical stage of COVID-19 using skin biopsy specimens and found microthrombi, deposition of C5b-9 and MASP2, as well as differential expression of MxA and SIN3A in severe/critical cases. These findings suggest the potential use of skin biopsies in identifying individuals at risk for disease progression.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marta Kopanska et al.
Summary: This study reviewed the latest research on the long-term effects of COVID-19 and found that the virus can potentially cause long-term complications in the nervous, circulatory, and respiratory systems. However, the studies included in the analysis were small or short-lasting, and further research is needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Angelica Giuliani et al.
Summary: This study aimed to identify circulating miRNAs associated with the risk of in-hospital mortality in COVID-19 patients. Serum samples of 12 COVID-19 patients were analyzed and the findings were validated in a separate cohort. The study identified significantly elevated levels of miR-320b and miR-483-5p in deceased patients compared to survivors.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Ryan J. Farr et al.
Summary: Host biomarkers, specifically miRNAs, are being studied for their potential as tools for improved COVID-19 detection. This study analyzed the expression of miRNAs in anterior nasal tissues from COVID-19 patients and identified eight miRNAs with altered expression, with miR-142-3p showing the strongest upregulation. Machine learning analysis revealed a three-miRNA signature (miR-30c-2-3p, miR-628-3p, and miR-93-5p) that can independently classify COVID-19 cases with 100% accuracy. These findings provide further insight into the host miRNA response to SARS-CoV-2 infection and suggest potential biomarkers for improved COVID-19 detection.
Review
Immunology
Hsiuying Wang
Summary: COVID-19 might induce anti-NMDA receptor encephalitis, but the risk is not high. This study reviewed the literature to explore the association between COVID-19 and anti-NMDA receptor encephalitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenzhe Wu et al.
Summary: This study reveals the impact of SARS-CoV-2 on the sncRNA profiles, with tRFs being the most significantly affected. It also identifies novel CoV2-derived small ncRNAs.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Qiqi Zeng et al.
Article
Cardiac & Cardiovascular Systems
Jason D. Roh et al.
Summary: A case-control plasma proteomics study in COVID-19 patients reveals that the senescence-associated secretory phenotype is the dominant process associated with disease severity and cardiac involvement. FSTL3 and ADAMTS13 are among the proteins most strongly associated with myocardial stress and injury. These findings are validated in a larger COVID-19 patient cohort and animal models, providing new insights into the pathophysiology of COVID-19 cardiovascular complications.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Yu Liang et al.
Review
Neurosciences
Harikesh Dubey et al.
Summary: Pregnant women are particularly vulnerable to SARS-CoV-2 infection and it could negatively impact fetal brain development through various mechanisms. There is evidence of mother to fetus transmission, which could lead to neuroinvasion. Even in the absence of transmission, disrupted placental development and immune activation could result in negative neurodevelopmental outcomes. Long-term studies are needed to understand the potential neurodevelopmental disorders in pregnant women caused by SARS-CoV-2.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ceren Eyileten et al.
Summary: By utilizing bioinformatic and co-expression analysis, this study identified and validated miRNAs associated with thrombosis in COVID-19 patients, which can serve as potential diagnostic and prognostic biomarkers for disease severity. The findings contribute to our understanding of the pathogenesis of COVID-19 and the identification of novel predictive markers.
Article
Genetics & Heredity
Asuman Gedikbasi et al.
Summary: This study found that the miRNA miR-155-5p was significantly upregulated in COVID-19 patients and was associated with disease severity. Overexpression of miR-155-5p increased inflammatory cytokine production and promoted COVID-19 progression. The study suggests that miR-155 may facilitate immune inflammation by targeting SOCS1 and is associated with disease prognosis.
Article
Immunology
Alessandra Giannella et al.
Summary: This study identified circulating miRNAs associated with the severity and mortality of COVID-19. The findings suggest that the pathogenesis of COVID-19 may involve impaired interferon and antiviral responses, inflammation, organ damage, and cardiovascular failure.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Tania R. Dias et al.
Summary: This article discusses miRNAs related to SARS-CoV-2 that are dysregulated in cancer and may impact the immune response to vaccines. The authors propose seven potential miRNAs as prognostic biomarkers for stratifying cancer patients, aiding in personalized treatment.
Review
Immunology
Seyed Shahabeddin Mortazavi-Jahromi et al.
Summary: Immunothrombosis is a pivotal immunohemostatic response, closely related to interactions between the immune and coagulation systems. Uncontrolled immunothrombosis in critical COVID-19 patients can be life-threatening due to hyperinflammation and cytokine storms activating the coagulation system, leading to a vicious cycle of immune-inflammatory responses and severe complications. MicroRNAs play a key role in balancing pro/anticoagulant and pro-/antiinflammatory factors, and any disruption in their optimal expression levels can result in complications. Various interfering factors, such as miRNA-single nucleotide polymorphisms, complement system components, NADPH oxidases, and reactive oxygen species, can affect the expressions/functions of miRNAs in the context of uncontrolled immunothrombosis in critical COVID-19 patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Yusheng Li et al.
Summary: In this study, miR-548d-5p was found to be downregulated in OA samples and IL-1 beta-stimulated chondrocytes. It was shown to protect chondrocytes against IL-1 beta-induced damage through direct inhibition of SP1.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Andrea Latini et al.
Summary: This study reveals a low expression of hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients and demonstrates its functional role in regulating ACE2 and DPP4 levels, suggesting its potential as a therapeutic target for COVID-19.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Mamta Panda et al.
Summary: This review provides an overview of the critical miRNA molecules and their regular expression in patients with COVID-19 infection and associated comorbidities. It discusses the potential of miRNA in reducing the severity of the illness and highlights the role of host and viral miRNAs in COVID-19 pathogenesis.
Article
Leyla Tahrani Hardin et al.
International Journal of Cell Biology
(2022)
Article
Genetics & Heredity
Kiarash Roustai Geraylow et al.
Summary: This article summarizes the data on miRNA dysregulation in COVID-19. miRNAs are considered as factors affecting the course of COVID-19 and have potential therapeutic targets.
Article
Cell Biology
Mandana AmeliMojarad et al.
Summary: This study investigated the effects of simvastatin on patients with Type 2 diabetes mellitus (T2DM) and COVID-19. The results showed that simvastatin can increase the expression of miR-150-5p, leading to downregulation of immune-stimulating genes and a decrease in lipid levels. Therefore, simvastatin can be suggested as an adjunct therapy, especially for T2DM patients with COVID-19.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Alexandra Ioana Moatar et al.
Summary: This study characterized the biological impact of differentially expressed microRNAs in COVID-19 disease by analyzing their effect on five distinct tissue transcriptomes. The results revealed that upregulated microRNAs control processes such as mitochondrial respiration and cytokine and cell surface receptor signaling pathways, while downregulated microRNAs are primarily involved in processes related to the mitotic cell cycle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Chih-Yun Yang et al.
Summary: SARS-CoV-2 infection can lead to immunosuppression and cytokine storm, causing lung damage and death. miRNAs play crucial roles in the immune response and pathogenesis of SARS-CoV-2, potentially participating in the regulation of SARS-CoV-2 infection and replication through various mechanisms. SARS-CoV-2-related miRNAs may serve as biomarkers for predicting patient outcomes, and dietary polyphenolic compounds could protect against SARS-CoV-2 infection by modulating miRNA expression.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Ankita Garg et al.
Summary: Elevated levels of cardiovascular and inflammatory microRNAs were observed in critically ill COVID-19 patients, suggesting a specific response and cardiac involvement of COVID-19. MiR profiles showed potential for differentiating between severe COVID-19 and Influenza-ARDS patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cell Biology
Jacopo Sabbatinelli et al.
Summary: The expression levels of miR-146a-5p related to inflammaging changed in COVID-19 patients after receiving treatment with Tocilizumab, with patients who did not respond to the drug having lower levels of miR-146a-5p and experiencing worse outcomes. This blood-based biomarker may offer insights into the molecular link between inflammaging and the clinical course of COVID-19, providing a better understanding for using biologic drugs against this global health threat.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Infectious Diseases
Mohammad Fayyad-Kazan et al.
Summary: The study compared the expression of circulating miRNAs in COVID-19 patients and healthy donors, revealing miR-19a-3p, miR-19b-3p, and miR-92a-3p as potential diagnostic biomarkers and therapeutic targets. ROC curve analyses showed high AUC values for these miRNAs, indicating their robust diagnostic value.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Ruth P. Duecker et al.
Summary: This study investigated the post-transcriptional gene regulation by global microRNA expression in 21 critically ill SARS-CoV-2 patients, revealing significantly elevated inflammatory and coagulation markers in severe respiratory failure patients. The dysregulation of miRNA expression, particularly the downregulation of miR-320 family members, was found to be associated with disease severity, highlighting the potential of miRNA-320s as biomarkers for severe progressive SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Song Zhang et al.
Summary: This article summarizes the role of miRNA in COVID-19 infection and suggests that COVID-19 cleverly exploits the interaction between miRNA and other biomolecules to evade host immune response. The study proposes that the miRNA-based interplay between the host and SARS-CoV-2 may be the primary cause of SARS-CoV-2 accessing and attacking host cells.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Agriculture, Dairy & Animal Science
Syed Waqas Ali Shah et al.
Summary: Ammonia induced autophagy in chicken BF by reducing ATPase activity and altering autophagy-related factors, leading to disturbance in energy metabolism. MiRNA-99a-3p was found to be the key player in this process.
Article
Medical Laboratory Technology
David De Gonzalo-Calvo et al.
Summary: This study demonstrated a close association between the circulating miRNA profile of COVID-19 patients and disease severity. Analysis of miRNA levels proved useful in distinguishing between ICU patients and ward patients, as well as between ICU nonsurvivors and survivors. The potential of miRNA signatures in predicting disease progression in critical COVID-19 patients was found to be superior to traditional laboratory parameters such as leukocyte counts, CRP, and D-dimer levels.
TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
J. Tyson McDonald et al.
Summary: The research demonstrates that miR-2392 is associated with SARS-CoV-2 infection, with potential for use in COVID-19 detection and as a target for antiviral therapy. Targeting miR-2392 can significantly reduce SARS-CoV-2 viability, indicating a potential treatment for COVID-19.
Article
Cell Biology
Shasha Li et al.
Article
Cell Biology
Hang Wu et al.
Summary: miR-27a-3p plays a crucial role in human adipogenesis by repressing PPARγ, while LPL is not involved in the regulation of human adipogenesis.
Article
Cell Biology
Cai-xia Li et al.
Summary: The study revealed decreased leukocytes and lymphocytes in COVID-19 patients, as well as identified numerous differentially expressed mRNAs, miRNAs, and lncRNAs involved in immune responses and cytokine pathways.
MEDIATORS OF INFLAMMATION
(2021)
Article
Oncology
Hongliang Liao et al.
Summary: Accumulating studies have suggested the significant role of microRNAs (miRs) in the development and progression of lung cancer, particularly in non-small cell lung cancer (NSCLC). This study investigated the association between miR-454-3p and NSCLC progression and found that miR-454-3p suppressed NSCLC cell proliferation and metastasis by targeting TGFB2, suggesting it as a promising strategy for treating NSCLC.
Review
Pediatrics
Madhusudan Samprathi et al.
Summary: Biomarkers play a crucial role in the COVID-19 pandemic, providing important information for clinical diagnosis and treatment. Different categories of biomarkers offer valuable insights, but there is still a lack of definitive answers on which biomarkers to evaluate when and in whom, and how best to utilize this information.
FRONTIERS IN PEDIATRICS
(2021)
Review
Infectious Diseases
Rafael Marchi et al.
Summary: MicroRNAs play crucial roles in SARS-CoV-2 infection and COVID-19 by regulating the immune response through interfering with viral gene cleavage and translation. The potential therapeutic use of miRNAs against COVID-19 and other viral infections has been highlighted in the identified studies.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Virology
Claudius Grehl et al.
Summary: The study conducted high throughput sequencing to analyze small circulating RNAs in the plasma of COVID-19 patients, revealing the presence of SARS-CoV-2 derived small RNAs. These virus-derived small RNAs were detectable even after recovery, and differential abundance of miRNAs discriminated between different severity of cases.
Article
Microbiology
Ryan J. Farr et al.
Summary: This study analyzed the host miRNA response to COVID-19 and identified a three-miRNA signature that can independently classify COVID-19 cases with high accuracy. The findings suggest that miRNA profiling could potentially improve COVID-19 detection and patient management.
Article
Cell Biology
Irma Saulle et al.
Summary: Research has shown that the transcriptomic profile of pregnant women is significantly altered in different anatomical districts following SARS-CoV-2 infection, even in the absence of clinical symptoms and vertical transmission. The combination of miRNA and antiviral/immune factors seems to control both the infection and the dysfunctional immune reaction, representing a potential therapeutic target against SARS-CoV-2.
Article
Biochemistry & Molecular Biology
Bobin Mi et al.
Summary: The upregulation of miR-4485 in COVID-19 patients negatively regulates osteogenic differentiation, potentially targeting Toll-like receptor 4 (TLR-4) and suppressing osteoblastic differentiation in vitro. These findings suggest a promising target for promoting fracture healing and treating osteoporosis in COVID-19 patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Immunology
Kumari Chandan et al.
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Muserref Duygu Sacar Demirci et al.
Article
Medical Laboratory Technology
Caixia Li et al.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Article
Genetics & Heredity
Rahila Sardar et al.
FRONTIERS IN GENETICS
(2020)
Article
Oncology
Hao Tang et al.
CLINICAL AND TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Yan-Mei Chen et al.
Article
Biochemistry & Molecular Biology
Ahmedz Widiasta et al.
NON-CODING RNA RESEARCH
(2020)
Article
Genetics & Heredity
Mekala Janaki Ramaiah
Article
Physiology
Kun Tang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Medicine, Research & Experimental
Xuebiao Tang et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Review
Endocrinology & Metabolism
Jacob O'Brien et al.
FRONTIERS IN ENDOCRINOLOGY
(2018)
Review
Genetics & Heredity
Erika Girardit et al.
FRONTIERS IN GENETICS
(2018)
Article
Oncology
Dongli Zhao et al.
Article
Biochemistry & Molecular Biology
James P. Broughton et al.
Review
Oncology
Shuibin Lin et al.
NATURE REVIEWS CANCER
(2015)
Article
Medicine, General & Internal
Chiu-Jung Huang et al.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2014)
Article
Clinical Neurology
Raquel Ferreira et al.
Review
Pathology
M. Bhaskaran et al.
VETERINARY PATHOLOGY
(2014)
Article
Multidisciplinary Sciences
Ian Dunham et al.
Review
Cell Biology
Zhuo Zhang et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2012)
Review
Biotechnology & Applied Microbiology
Maria I. Almeida et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
(2011)
Review
Cell Biology
Masafumi Inui et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2010)
Review
Biochemistry & Molecular Biology
Tomoko Kawamata et al.
TRENDS IN BIOCHEMICAL SCIENCES
(2010)
Review
Biochemistry & Molecular Biology
David P. Bartel
Review
Multidisciplinary Sciences
Danesh Moazed
Article
Multidisciplinary Sciences
Chimari Okada et al.
Review
Biochemistry & Molecular Biology
RS Pillai
Article
Multidisciplinary Sciences
AM Denli et al.
Article
Biochemistry & Molecular Biology
P Shannon et al.