Respiratory infections and type 1 diabetes: Potential roles in pathogenesis

Among the environmental factors associated with type 1 diabetes (T1D), viral infections of the gut and pancreas has been investigated most intensely, identifying enterovirus infections as the prime candidate trigger of islet autoimmunity (IA) and T1D development. However, the association between respiratory tract infections (RTI) and IA/T1D is comparatively less known. While there are significant amounts of epidemiological evidence supporting the role of respiratory infections in T1D, there remains a paucity of data characterising infectious agents at the molecular level. This gap in the literature precludes the identification of the specific infectious agents driving the association between RTI and T1D. Furthermore, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the development of IA/T1D remains undeciphered. Here, we provide a comprehensive overview of the evidence to date, implicating RTIs (viral and non-viral) as potential risk factors for IA/T1D.

Automated summary

Among environmental factors associated with T1D, enterovirus infections have been identified as the main trigger for T1D development. However, the association between respiratory tract infections and T1D is not well understood. There is a lack of molecular-level data characterizing infectious agents, preventing the identification of specific agents driving the association between respiratory infections and T1D. The impact of SARS-CoV-2 infections on IA/T1D development remains unclear.