期刊
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
卷 43, 期 8, 页码 1425-1428出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IAE.0000000000003847
关键词
Birdshot chorioretinopathy; inner retina; lymphocytic infiltrate
This study describes new histological findings of the inner retina in birdshot chorioretinopathy. The study found focal perivascular lymphocytic infiltration at the optic nerve head, extending into the adjacent inner retina, particularly affecting the ganglion and nerve fiber layers. This may result in bipolar and Muller cell dysfunction, leading to an electronegative electroretinogram.
Purpose:To describe new histological findings involving the inner retina in birdshot chorioretinopathy.Methods:Evaluation of the inner retinal pathology of the eye of a patient with bilateral birdshot chorioretinopathy who underwent enucleation for a unilateral ciliochoroidal melanoma.Results:Histopathological sections showed focal perivascular lymphocytic infiltration at the optic nerve head that extended into the adjacent inner retina, mainly involving the ganglion and nerve fiber layers.Conclusion:We have previously shown that birdshot chorioretinopathy has multiple foci of lymphocytes in the choroid. This is the first report that demonstrates lymphocytic infiltration of the inner retinal layers. This may lead to the bipolar and Muller cell dysfunction that ultimately results in an electronegative electroretinogram.
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