Comparison of perioperative serum osteocrin concentrations between surgical techniques in dogs with cranial cruciate ligament rupture

The cranial cruciate ligament (CCL) rupture is a common orthopedic disease in dogs that is usually managed with tibial plateau leveling osteotomy (TPLO) or extracapsular lateral suture (ECLS). Osteotomy is generally associ-ated with some complications, including nonunion. The periosteum plays an important role in bone growth and remodeling. Osteocrin (OSTN), which was recently identified and is involved in bone formation and differen-tiation, is produced in the periosteum and osteoblasts. The aimed to investigate whether the concentrations of serum OSTN change before and after stifle surgery in dogs and compare the OSTN concentrations in the two surgical techniques (TPLO: n = 20 vs. ECLS: n = 36). The postoperative serum OSTN concentration in the TPLO group was significantly lower than the preoperative value (p < 0.05), while serum OSTN concentrations differed statistically between the preoperative and suture-removal periods. In contrast, no significant differences were observed in the ECLS group. In conclusion, osteotomy affects serum OSTN concentrations during the perioper-ative period in dogs, which may be related to periosteal injury.

Automated summary

Cranial cruciate ligament (CCL) rupture is a common orthopedic disease in dogs, and it is usually treated with tibial plateau leveling osteotomy (TPLO) or extracapsular lateral suture (ECLS). This study aimed to investigate the changes in serum OSTN concentrations before and after stifle surgery in dogs and compare the concentrations between TPLO and ECLS. The results showed that serum OSTN concentrations decreased significantly after TPLO surgery, while no significant differences were observed in the ECLS group.