期刊
RENAL FAILURE
卷 45, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/0886022X.2023.2199097
关键词
Omicron infection; end stage kidney disease; abnormal liver function; ICU; platelet-albumin-bilirubin score; neutrophil-to-lymphocyte ratio; inflammation
The objective of this study was to develop clinical scores to predict the risk of ICU admission in patients with ESKD and COVID-19. Clinical characteristics and liver function changes were analyzed in 100 patients, and ROC curves were plotted to identify predictive scores. Patients transferred to the ICU commonly experienced symptoms such as shortness of breath and gastrointestinal bleeding. The PALBI and NLR scores showed good predictive value for ICU admission risk.
Objectives: The objective of this study was to develop clinical scores to predict the risk of intensive care unit (ICU) admission in patients with COVID-19 and end stage kidney disease (ESKD). Methods: This was a prospective study in which 100 patients with ESKD were enrolled and divided into two groups: the ICU group and the non-ICU group. We utilized univariate logistic regression and nonparametric statistics to analyze the clinical characteristics and liver function changes of both groups. By plotting receiver operating characteristic curves, we identified clinical scores that could predict the risk of ICU admission. Results: Out of the 100 patients with Omicron infection, 12 patients were transferred to the ICU due to disease aggravation, with an average of 9.08 days from hospitalization to ICU transfer. Patients transferred to the ICU more commonly experienced shortness of breath, orthopnea, and gastrointestinal bleeding. The peak liver function and changes from baseline in the ICU group were significantly higher, with p values <.05. We found that the baseline platelet-albumin-bilirubin score (PALBI) and neutrophil-to-lymphocyte ratio (NLR) were good predictors of ICU admission risk, with area under curve values of 0.713 and 0.770, respectively. These scores were comparable to the classic Acute Physiology and Chronic Health Evaluation II (APACHE-II) score (p > .05). Conclusion: Patients with ESKD and Omicron infection who are transferred to the ICU are more likely to have abnormal liver function. The baseline PALBI and NLR scores can better predict the risk of clinical deterioration and early transfer to the ICU for treatment.
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