Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

Article Biochemistry & Molecular Biology

Kaempferol attenuates diabetic nephropathy in streptozotocin-induced diabetic rats by a hypoglycaemic effect and concomitant activation of the Nrf-2/Ho-1/antioxidants axis

Ali S. Alshehri

Summary: This study found that Kaempferol can prevent streptozotocin-induced diabetic nephropathy through its antioxidant potential, which is mediated by upregulation of the Nrf-2/HO-1 axis.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Review Biochemistry & Molecular Biology

Epigenetics in the pathogenesis of diabetic nephropathy

Xue Li et al.

Summary: This review discusses the important role of epigenetics in diabetic nephropathy, which affects the progression of the disease through various mechanisms and ultimately leads to a poor prognosis.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2022)

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Article Biochemistry & Molecular Biology

Triptolide Alleviates Podocyte Epithelial-Mesenchymal Transition via Kindlin-2 and EMT-Related TGF-β/Smad Signaling Pathway in Diabetic Kidney Disease

Lingyan Ren et al.

Summary: The study aimed to decipher the mechanism by which triptolide may prevent podocyte epithelial-mesenchymal transition, possibly by activating kindlin-2 and TGF-beta/Smad pathways. Triptolide treatment in diabetic mice was found to alleviate structural injuries and functional variations, increase protein and mRNA levels of key markers, and decrease expression of alpha-SMA through inactivation of kindlin-2 and downregulation of P-SMAD3 in the TGF-beta/Smad signaling pathway.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)

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Letter Oncology

Confusion about the article: Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-II

Jianquan Yang et al.

CANCER LETTERS (2022)

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Correction Cell Biology

Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy (vol 36, pg 243, 2020)

Lei Du et al.

CELL BIOLOGY AND TOXICOLOGY (2022)

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Article Biochemistry & Molecular Biology

MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy

Meng-Ran Li et al.

Summary: Recent studies have shown that upregulated MAD2B expression contributes to Numb depletion, activation of the Notch 1 signaling pathway, and ultimately leads to podocyte injury in diabetic nephropathy.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Triptolide Suppresses NF-κB-Mediated Inflammatory Responses and Activates Expression of Nrf2-Mediated Antioxidant Genes to Alleviate Caerulein-Induced Acute Pancreatitis

Jing Yang et al.

Summary: This study demonstrates that Triptolide can alleviate inflammation and tissue damage caused by acute pancreatitis by inhibiting NF-kappa B transactivation, modulating immune cell responses, and activating the Nrf2-mediated antioxidative system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Fisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome

Wenmin Dong et al.

Summary: This study finds that fisetin can alleviate high glucose-induced podocyte injury and STZ-induced DN by restoring autophagy-mediated CDKN1B/P70S6K pathway and inhibiting NLRP3 inflammasome.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

miR-188-3p abolishes germacrone-mediated podocyte protection in a mouse model of diabetic nephropathy in type I diabetes through triggering mitochondrial injury

Yunguang Wang et al.

Summary: This study investigates the role and functional mechanism of germacrone in type I diabetic nephropathy (DN). Germacrone was found to reduce blood glucose and proteinuria, protect against mitochondrial damage, limit ROS accumulation, and prevent podocyte apoptosis in a mouse model of type I DN. Furthermore, the upregulation of miR-188-3p in type I DN was reversed by germacrone, and miR-188-3p was found to aggravate mitochondrial damage and podocyte apoptosis in DN. The combination of germacrone and miR-188-3p antagonists may be a promising therapeutic strategy for DN.

BIOENGINEERED (2022)

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Article Chemistry, Medicinal

Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

Yan Jiao et al.

Summary: By screening against NLRP3-dependent pyroptosis, a novel compound J114 was discovered, which displayed significant inhibitory activity against human cell pyroptosis and showed distinct differences from existing pyroptosis inhibitors. Further studies revealed that J114 inhibited inflammasome activation by disrupting the interaction between NLRP3 or AIM2 and the adaptor protein ASC.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Immunology

Penehyclidine hydrochloride suppresses inflammation response and reduces podocyte injury in diabetic nephropathy by targeting fibrinogen-like protein 2

Hong-Bao Tan et al.

Summary: In this study, it was found that penehyclidine hydrochloride (PHC) may prevent podocyte injury in diabetic nephropathy (DN) through the inhibition of fibrinogen-like protein 2 (Fgl2), thereby suppressing inflammation.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Immunology

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model

Yanmin Gao et al.

Summary: Podocyte pyroptosis, an inflammatory form of cell death associated with Diabetic nephropathy (DN), can be protected against by ManNAc therapy through inhibiting mitochondrial injury and ROS/NLRP3 signaling pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Cell Biology

LncRNA FAF attenuates hypoxia/ischaemia-induced pyroptosis via the miR-185-5p/PAK2 axis in cardiomyocytes

Jie Gu et al.

Summary: This study reveals a novel lncRNA FAF/miR-185-5p/PAK2 axis as a crucial regulator in cardiomyocyte pyroptosis, which might be a potential therapeutic target of AMI.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Endocrinology & Metabolism

cAMP-response element binding protein mediates podocyte injury in diabetic nephropathy by targeting lncRNA DLX6-AS1

Wen Zheng et al.

Summary: The study identified cAMP-response element binding protein (CREB) as a key regulator of long non-coding RNA DLX6-AS1 in diabetic nephropathy (DN). CREB targeted DLX6-AS1 and aggravated renal inflammation, leading to podocyte injury. Inhibition of CREB reduced DLX6-AS1 levels and attenuated renal damage, suggesting that CREB may be a potential therapeutic target for the treatment of DN.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

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Article Biochemistry & Molecular Biology

Fungus-Derived 3-Hydroxyterphenyllin and Candidusin A Ameliorate Palmitic Acid-Induced Human Podocyte Injury via Anti-Oxidative and Anti-Apoptotic Mechanisms

Suchada Kaewin et al.

Summary: Diabetic nephropathy is a leading cause of end-stage renal disease. This study identified and characterized two natural compounds, 3-hydroxyterphenyllin and candidusin A, derived from a marine fungus, which can protect human podocytes from palmitic acid-induced injury through mechanisms involving free radical scavenging and upregulation of the anti-apoptotic Bcl2 protein.

MOLECULES (2022)

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Article Pharmacology & Pharmacy

Kaempferol From Penthorum chinense Pursh Attenuates Hepatic Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Inflammation Through Activation of the Nrf2/HO-1 Signaling Pathway

Yifan Chen et al.

Summary: This study investigates the protective effect of kaempferol (KAE) from Penthorum chinense Pursh on hepatic ischemia/reperfusion injury (HI/RI) and its specific mechanism. The results demonstrate that KAE pretreatment alleviates hepatocellular damage caused by ischemia/reperfusion, mainly by reducing oxidative stress and inflammation through the activation of the Nrf2/HO-1 signaling pathway.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Saikosaponin d Alleviates Liver Fibrosis by Negatively Regulating the ROS/NLRP3 Inflammasome Through Activating the ERβ Pathway

Kehui Zhang et al.

Summary: This study revealed that SSd alleviated liver fibrosis by negatively regulating the ROS/NLRP3 inflammasome through activating the ER beta pathway. The intervention of SSd in liver fibrosis mouse models decreased liver pathology damage, reduced expression of fibrosis markers, and lowered fibrosis scores.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Src Activation Aggravates Podocyte Injury in Diabetic Nephropathy via Suppression of FUNDC1-Mediated Mitophagy

Ting Zheng et al.

Summary: This study found that Src plays a key role in the development of diabetic nephropathy through the inhibition of FUNDC1-mediated mitophagy.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Cell Biology

Podocyte Injury in Diabetic Kidney Disease: A Focus on Mitochondrial Dysfunction

Simeng Liu et al.

Summary: Podocytes are essential for maintaining the glomerular filtration barrier and their injury plays a critical role in the development of albuminuria and diabetic kidney disease (DKD). Mitochondrial dysfunction is a key driver in podocyte injury in DKD, leading to energy crisis, oxidative stress, inflammation, and cell death. This review summarizes the recent advances in understanding the molecular mechanisms of mitochondrial damage and its impact on podocytes. It discusses various mitochondrial pathways involved in podocyte injury in DKD, such as mitochondrial dynamics, mitophagy, mitochondrial biogenesis, oxidative stress, and protein quality control. The review also explores the formation of mitochondria-associated membranes (MAMs) and their role in podocyte mitochondrial function. Finally, it examines the experimental evidence and potential future directions for targeting podocyte mitochondrial function in the treatment of DKD.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Pharmacology & Pharmacy

SGLT2 inhibitors suppress epithelial-mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway

Ruixue Guo et al.

Summary: This study demonstrates that the SGLT2 inhibitor dapagliflozin protects podocytes from diabetic nephropathy by regulating the IGF1R/PI3K signaling pathway.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Cdk5-Mediated Phosphorylation of Sirt1 Contributes to Podocyte Mitochondrial Dysfunction in Diabetic Nephropathy

Shuo Wang et al.

Summary: This study demonstrated that in diabetic conditions, the overactivity of Cdk5 leads to podocyte injury and mitochondrial dysfunction, whereas inhibition of Cdk5 can attenuate these injuries and dysfunctions by modulating Sirt1 phosphorylation. This suggests that Cdk5 may be a potential therapeutic target for the treatment of DN.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Article Chemistry, Multidisciplinary

Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy

Qian Cheng et al.

Summary: The study found that under hyperglycemic condition, caspase-11/4 and GSDMD-mediated pyroptosis are activated and involved in podocyte loss.

ACTA PHARMACOLOGICA SINICA (2021)

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Review Urology & Nephrology

The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease

Yu Sun et al.

Summary: Disorder of podocyte lipid metabolism is closely associated with various proteinuric kidney diseases, excessive lipid accumulation can lead to cellular dysfunction, ultimately resulting in cell hypertrophy, detachment, and death. Targeting podocyte lipid metabolism may represent a novel therapeutic strategy for patients with proteinuric kidney disease.

KIDNEY DISEASES (2021)

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Article Cell Biology

Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

Qiang Chen et al.

Summary: This study found that TPL improved neurobehavioral functions, reduced neuroinflammation and oxidative stress, and inhibited microglial activation and cell death in DHCA rats. Additionally, TPL activated the Nrf2 pathway and suppressed NF-kappa B activity, suggesting potential mechanisms for its neuroprotective effects.

AGING-US (2021)

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Review Medical Laboratory Technology

Pyroptosis in diabetic nephropathy

Abdullah Al Mamun et al.

Summary: Pyroptosis, a new mechanism in diabetic nephropathy, may be triggered by NLRP3 inflammasome activation, leading to excessive secretion of interleukins. Current studies have shown that pyroptosis-induced cell death is associated with various diabetic complications.

CLINICA CHIMICA ACTA (2021)

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Article Biochemistry & Molecular Biology

Dapagliflozin Reduces Urinary Albumin Excretion by Downregulating the Expression of cAMP, MAPK, and cGMP-PKG Signaling Pathways Associated Genes

Guoping Chen et al.

Summary: Dapagliflozin (DAP) can reduce urinary albumin excretion in patients with type 2 diabetes and renal impairment, mainly by regulating the expression of genes related to cell membrane components and cell connections. In addition, DAP also reduces urinary albumin excretion by downregulating gene clusters associated with key signaling pathways in the progression of diabetic nephropathy.

GENETIC TESTING AND MOLECULAR BIOMARKERS (2021)

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Article Immunology

Carnosine alleviates podocyte injury in diabetic nephropathy by targeting caspase-1-mediated pyroptosis

Wei Zhu et al.

Summary: The study demonstrates the protective effects of carnosine on glomerular podocytes in diabetic nephropathy, highlighting its potential as a therapeutic agent by targeting caspase-1. The mechanism involves inhibition of podocyte pyroptosis and inflammation, with promising results in both in vivo and in vitro models. This novel role of carnosine in alleviating podocyte injury provides new insights for potential treatment of diabetic nephropathy.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

Triptolide Improves Renal Injury in Diabetic Nephropathy Rats through TGF-β1/Smads Signal Pathway

Ruoyu Pang et al.

Summary: The study demonstrated that Triptolide significantly alleviated renal injury in diabetic rats, potentially by inhibiting the TGF-beta 1/Smads signaling pathway.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2021)

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Article Pharmacology & Pharmacy

Triptolide improves myocardial fibrosis in rats through inhibition of nuclear factor kappa B and NLR family pyrin domain containing 3 inflammasome pathway

Jianyao Shen et al.

Summary: The study found that treatment with TPL effectively improved cardiac function in rats with myocardial fibrosis, reduced tissue injury and pathological damage, inhibited inflammatory and fibrosis factor levels, and suppressed the activation of the NLRP3 inflammasome.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Guoyi Tang et al.

Summary: Chinese medicine has shown promising clinical benefits in the treatment and management of diabetic nephropathy, with its multi-target function affecting crucial mechanisms such as glucose/lipid metabolism regulation, antioxidation, anti-inflammation, anti-fibrosis, and podocyte protection. Studies have emphasized the clinical efficacy of Chinese medicines and their bioactive components, with a focus on identifying the underlying mechanisms and molecular targets.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Nutrition & Dietetics

AMPK Activity: A Primary Target for Diabetes Prevention with Therapeutic Phytochemicals

Min-Yu Chung et al.

Summary: Natural phytochemicals found in plants have been traditionally used as medicines for preventing chronic diseases like diabetes in East Asia since ancient times. These compounds are characterized as having few side effects, and scientific research has accumulated mounting evidence for their efficacy in preventing metabolic syndrome disorders including diabetes.

NUTRIENTS (2021)

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Article Medicine, Research & Experimental

Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation

Qijing Wu et al.

Summary: Apigenin has a protective role against DOX-induced nephrotoxicity without compromising its cytotoxicity in malignant tumors. It may serve as a potential protective agent against renal injury and inflammatory diseases, offering promise in attenuating renal toxicity in cancer patients undergoing DOX treatment.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Cell Biology

Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy

Li Chen et al.

Summary: The study revealed senescence occurring in DN mice and the reversal effect of CO, which improved autophagy dysfunction through dissociating Beclin-1-Bcl-2 complex. Further results showed that autophagy inhibitors blocked the improvement of CO on senescence, and autophagy regulated the degradation of senescence-related secretory phenotype.

CELL PROLIFERATION (2021)

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Review Immunology

The Multiple Roles of Fibroblast Growth Factor in Diabetic Nephropathy

Junyu Deng et al.

Summary: Diabetic nephropathy is a common complication in the late stages of diabetes, with risk factors including type 1 diabetes, hypertension, high protein intake, and smoking. The development of DN is associated with metabolism, oxidative stress, genetic factors, and renal microvascular disease. The role of fibroblast growth factor in DN development is discussed in this review, with potential implications for new prevention and treatment strategies.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Multidisciplinary Sciences

Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy

Jeong Suk Kang et al.

Summary: This study demonstrates that klotho has a protective effect against podocyte injury in diabetic nephropathy by modulating oxidative stress, endoplasmic reticulum stress, inflammation, and fibrosis pathways induced by lipotoxicity.

PLOS ONE (2021)

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Review Biochemistry & Molecular Biology

Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway

Bercis Imge Ucar et al.

Summary: Ischemia/reperfusion (I/R) injury has significant clinical implications for various organs. Oxidative stress plays a critical role in I/R pathogenesis, and the Nrf2/HO-1 pathway could be a promising therapeutic strategy for preventing I/R injury.

ANTIOXIDANTS (2021)

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Review Medicine, General & Internal

The Active Compounds and Therapeutic Target of Tripterygium wilfordii Hook. f. in Attenuating Proteinuria in Diabetic Nephropathy: A Review

Peng Liu et al.

Summary: Tripterygium wilfordii Hook. f. (TWHF) and its active compounds, such as tripterygium wilfordii polyglycosides (TWPs), triptolide (TP), and celastrol, have been found to exhibit effects in attenuating diabetic nephropathy through anti-inflammation, anti-oxidative stress, anti-fibrosis, and other mechanisms.

FRONTIERS IN MEDICINE (2021)

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Article Urology & Nephrology

Novel Anti-inflammatory and Anti-fibrotic Agents for Diabetic Kidney Disease-From Bench to Bedside

Susanne B. Nicholas

Summary: Chronic low-grade inflammation, known as metaflammation or metainflammation, is linked to chronic kidney disease and diabetes. The interplay among hyperglycemia, oxidative stress, and inflammation in the pathogenesis of diabetic kidney disease has been explored. Therapeutic agents targeting inflammatory processes and signaling pathways have potential for improving the management of DKD, but may be insufficient due to the complex nature of the disease.

ADVANCES IN CHRONIC KIDNEY DISEASE (2021)

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Review Biochemistry & Molecular Biology

Triptolide: reflections on two decades of research and prospects for the future

Lu Tong et al.

Summary: This review summarizes the progress in material sourcing, molecular mechanisms, clinical progress, and new drug design strategies of triptolide over the past two decades, and discusses some prospects for the future development of triptolide.

NATURAL PRODUCT REPORTS (2021)

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Article Cell Biology

Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy

Lei Du et al.

CELL BIOLOGY AND TOXICOLOGY (2020)

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Article Oncology

Dopamine 1 receptor activation protects mouse diabetic podocytes injury via regulating the PKA/NOX-5/p38 MAPK axis

Xiaoting Shao et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Lucas Opazo-Rios et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Urology & Nephrology

Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease

Jakob Appel Ostergaard et al.

JOURNAL OF NEPHROLOGY (2020)

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Article Cell Biology

Sodium-glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice

Ting Cai et al.

CELL DEATH & DISEASE (2020)

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Article Cell Biology

Inhibition of miR-17∼92 Cluster Ameliorates High Glucose-Induced Podocyte Damage

Xiaobao Fan et al.

MEDIATORS OF INFLAMMATION (2020)

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Review Biochemistry & Molecular Biology

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

Li Wang et al.

MOLECULAR ASPECTS OF MEDICINE (2020)

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Article Medicine, General & Internal

Dapagliflozin in Patients with Chronic Kidney Disease

Hiddo J. L. Heerspink et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Endocrinology & Metabolism

Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial

David C Wheeler et al.

Lancet Diabetes & Endocrinology (2020)

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Article Immunology

Therapeutic Potential of Triptolide as an Anti-Inflammatory Agent in Dextran Sulfate Sodium-Induced Murine Experimental Colitis

Bufu Tang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Correction Biochemistry & Molecular Biology

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway (vol 13, pg 1266, 2017)

Fei Han et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Article Medicine, Research & Experimental

PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease

Yajuan Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Biochemistry & Molecular Biology

3′-O-β-d-glucopyranosyl-α,4,2′,4′,6′-pentahydroxy-dihydrochalcone, from Bark of Eysenhardtia polystachya Prevents Diabetic Nephropathy via Inhibiting Protein Glycation in STZ-Nicotinamide Induced Diabetic Mice

Rosa Martha Perez Gutierrez et al.

MOLECULES (2019)

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Article Cell Biology

Klotho inhibits PKCα/p66SHC-mediated podocyte injury in diabetic nephropathy

Wei Jiang et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2019)

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Article Endocrinology & Metabolism

CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy

Jia Sun et al.

JOURNAL OF ENDOCRINOLOGY (2019)

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Article Cell Biology

Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway

Fei Han et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Medicine, Research & Experimental

A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

Jay C. Jha et al.

CLINICAL SCIENCE (2018)

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Article Biochemistry & Molecular Biology

Triptolide Attenuates Renal Tubular Epithelial-mesenchymal Transition Via the MiR-188-5p-mediated PI3K/AKT Pathway in Diabetic Kidney Disease

Mei Xue et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

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Article Cell Biology

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

Ming Wu et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

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Article Biochemistry & Molecular Biology

Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway

Fei Han et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

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Article Toxicology

Nephrotoxicity in Rats Exposed to Paracetamol: The Protective Role of Moralbosteroid, a Steroidal Glycoside

Gaurav Gupta et al.

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY (2017)

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Article Biochemistry & Molecular Biology

Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy

Xing-gang Dong et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2017)

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Article Medicine, General & Internal

Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-β/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues

Zhong Ju Xu et al.

MEDICINE (2017)

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Article Medicine, Research & Experimental

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

Xiao-yu Li et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

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Review Urology & Nephrology

Diagnosis and Management of Type 2 Diabetic Kidney Disease

Simit M. Doshi et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway

Haijie Yu et al.

CARDIOVASCULAR TOXICOLOGY (2016)

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Review Biochemistry & Molecular Biology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

Vijay A. K. Rathinam et al.

CELL (2016)

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Review Biochemistry & Molecular Biology

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Agnieszka Loboda et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

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Article Endocrinology & Metabolism

Triptolide Improves Diabetic Nephropathy by Regulating Th Cell Balance and Macrophage Infiltration in Rat Models of Diabetic Nephropathy

H. Guo et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2016)

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Article Physiology

Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-kappa B Signaling Pathway

Ying Zhou et al.

KIDNEY & BLOOD PRESSURE RESEARCH (2016)

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Review Urology & Nephrology

Podocyte injury and its consequences

Michio Nagata

KIDNEY INTERNATIONAL (2016)

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Review Pharmacology & Pharmacy

Targeting the podocyte to treat glomerular kidney disease

Mark A. Lal et al.

DRUG DISCOVERY TODAY (2015)

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Article Immunology

Anti-inflammatory effects of triptolide on IgA nephropathy in rats

Liyu He et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2015)

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Article Medicine, Research & Experimental

Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy

Ruixia Ma et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)

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Article Cell Biology

Modulation of Nrf2 expression alters high glucose-induced oxidative stress and antioxidant gene expression in mouse mesangial cells

Hang Li et al.

CELLULAR SIGNALLING (2011)

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Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

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