期刊
JOURNAL OF VIROLOGY
卷 90, 期 13, 页码 6148-6158出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00419-16
关键词
-
类别
资金
- Agence Nationale de Recherches sur le Sida et les Hepatites Virales (ANRS) [2011409]
- Foundation pour la Recherche Medicale
- ISCIII [CIIP15/00014, PI11/00249, PI14/01058]
- Belgian Fund for Scientific Research (FRS-FNRS)
- Redes Tematicas de Investigacion en SIDA
- Accion Estrategica en Salud, Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica
- Instituto de Salud Carlos III, Fondos FEDER [ISCIII RETIC RD12/0017/0002]
- ICREA Funding Source: Custom
HIV establishes reservoirs of infected cells that persist despite effective antiretroviral therapy (ART). In most patients, the virus begins to replicate soon after treatment interruption. However, a low frequency of infected cells at the time of treatment interruption has been associated with delayed viral rebound. Likewise, individuals who control the infection spontaneously, so-called HIV-1 controllers (HICs), carry particularly low levels of infected cells. It is unclear, however, whether and how this small number of infected cells contributes to durable viral control. Here we compared 38 HICs with 12 patients on effective combined antiretroviral therapy (cART) and found that the low frequency of infected cells in the former subjects was associated both with less efficient viral reactivation in resting CD4(+) T cells and with less efficient virion production ex vivo. We also found that a potent HIV-specific CD8(+) T cell response was present only in those HICs whose CD4(+) T cells produced virus ex vivo. Long-term spontaneous control of HIV infection in HICs thus appears to be sustained on the basis of the inefficient reactivation of viruses from a limited number of infected cells and the capacity of HICs to activate a potent HIV-specific CD8(+) T cell response to counteract efficient viral reactivation events.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据