期刊
JOURNAL OF VIROLOGY
卷 90, 期 13, 页码 5850-5854出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01979-15
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资金
- IZKF Erlangen [A62, A71]
- Deutsche Forschungsgemeinschaft (DFG) [SFB796 B3]
Research in the last 2 decades has demonstrated that a specific organelle of the cell nucleus, termed PML nuclear body (PML-NB) or nuclear domain 10 (ND10), is frequently modified during viral infection. This correlates with antagonization of a direct repressive function of individual PML-NB components, such as the PML, hDaxx, Sp100, or ATRX protein, that are able to act as cellular restriction factors. Recent studies now reveal an emerging role of PML-NBs as coregulatory structures of both type I and type II interferon responses. This emphasizes that targeting of PML-NBs by viral regulatory proteins has evolved as a strategy to compromise intrinsic antiviral defense and innate immune responses.
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