期刊
JOURNAL OF VIROLOGY
卷 90, 期 19, 页码 8384-8388出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00502-16
关键词
-
类别
资金
- Wellcome Trust [Wtd004098]
- MRC [MC_UU_12014/3] Funding Source: UKRI
The human papillomavirus (HPV) life cycle is tightly linked to differentiation of the infected epithelium. This means that viral proteins must exert control over epithelial gene expression in order to optimize viral production. The HPV E2 protein controls replication, transcription, and viral genome partitioning during the viral infectious life cycle. It consists of a nucleic acid-binding domain and a protein-protein interaction domain separated by a flexible serine and arginine-rich hinge region. Over the last few years, mounting evidence has uncovered an important new role for E2 in viral and cellular RNA processing. This Gem discusses the role of E2 in controlling the epithelial cellular environment and how E2 might act to coordinate late events in the viral replication cycle.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据