Did the UK's public health shielding policy protect the clinically extremely vulnerable during the COVID-19 pandemic in Wales? Results of EVITE Immunity, a linked data retrospective study

Article Medicine, General & Internal

Association between multimorbidity and mortality in a cohort of patients admitted to hospital with COVID-19 in Scotland

Utkarsh Agrawal et al.

Summary: The presence of multimorbidity among COVID-19 hospitalized patients is significantly associated with mortality risk. Multimorbidity is an independent risk factor for mortality in these individuals.

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE (2022)

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Article Public, Environmental & Occupational Health

The impact of the COVID-19 pandemic on mental health and well-being of people living with a long-term physical health condition: a qualitative study

A. Fisher et al.

Summary: This study found that living with long-term physical health conditions during the COVID-19 pandemic had a significant impact on mental health and well-being. Key issues included fear and anxiety, the impact of isolation on mental health, healthcare experience, and anxiety about the future. Providing practical and social support is crucial for individuals with LTCs during a pandemic.

BMC PUBLIC HEALTH (2021)

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Article Medicine, General & Internal

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

Damian F. Santomauro et al.

Summary: This study aimed to quantify the impact of the COVID-19 pandemic on the prevalence and burden of major depressive disorder and anxiety disorders globally in 2020. The findings showed that the pandemic led to increased prevalence of major depressive disorder and anxiety disorders, with females and younger age groups being more affected. The pandemic has created an increased urgency to strengthen mental health systems in most countries and mitigation strategies are needed to address the burden of these mental disorders.

LANCET (2021)

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Review Immunology

A Systematic Review and Meta-Analysis of Inpatient Mortality Associated With Nosocomial and Community COVID-19 Exposes the Vulnerability of Immunosuppressed Adults

Mark J. Ponsford et al.

Summary: The risk of mortality is higher in hospital-acquired COVID-19 patients compared to those with community-acquired infection, especially among immunosuppressed patients. The findings emphasize the importance of tailored clinical interventions for preventing nosocomial COVID-19, particularly for at-risk populations.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Relation of severe COVID-19 in Scotland to transmission-related factors and risk conditions eligible for shielding support: REACT-SCOT case-control study

Paul M. McKeigue et al.

Summary: This study investigated the rate ratio of severe COVID-19 in individuals eligible for the shielding programme in Scotland during the epidemic waves, as well as the relationship between severe COVID-19 and transmission-related factors. The findings showed that vulnerable individuals in shielding had a higher risk of severe COVID-19 compared to the general population, with risks associated with the number of household members and recent exposure to hospitals.

BMC MEDICINE (2021)

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Article Respiratory System

Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults

Mark J. Ponsford et al.

Summary: The burden of nosocomial SARS-CoV-2 infection remains poorly defined. Inpatient mortality for nosocomial infection was consistently higher than community-acquired infection. Those with hospital-acquired infection were older and frailer than those infected within the community, with a median diagnosis occurring 30 days following admission.

THORAX (2021)

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Article Multidisciplinary Sciences

Comparison of COVID-19 outcomes among shielded and non-shielded populations

Bhautesh D. Jani et al.

Summary: The study in West of Scotland found that while shielding high-risk individuals can reduce the infection and mortality rates of COVID-19, they still face a higher risk of death. Therefore, to be more effective as a population strategy, the criteria for shielding would need to be expanded to include more conditions, especially the elderly.

SCIENTIFIC REPORTS (2021)

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Article Respiratory System