期刊
JOURNAL OF VIROLOGY
卷 90, 期 12, 页码 5538-5540出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00737-15
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资金
- Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)
- Gouvernement du Canada | Canadian Institutes of Health Research (CIHR) [MOP-81244]
To replicate, all viruses depend entirely on the enslavement of host cell ribosomes for their own advantage. To this end, viruses have evolved a multitude of translational strategies to usurp the ribosome. RNA-based structures known as internal ribosome entry sites (IRESs) are among the most notable mechanisms employed by viruses to seize host ribosomes. In this article, we spotlight the intergenic region IRES from the Dicistroviridae family of viruses and its importance as a model for IRES-dependent translation and in understanding fundamental properties of translation.
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