Antimicrobial prophylaxis: To do or not to do? This is the question

Article Oncology

The transition from transrectal to transperineal prostate biopsy without antibiotic prophylaxis: Cancer detection rates and complication rates

Renee Hogenhout et al.

Summary: TPB has no different csPCa detection rate from TRB taking CR/IDC into account. TPB is, however, preferable because of less infectious complications, even if AP is omitted.

PROSTATE CANCER AND PROSTATIC DISEASES (2023)

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Article Urology & Nephrology

Should Transperineal Prostate Biopsy Be the Standard of Care?

Rand N. Wilcox Vanden N. Berg et al.

Summary: The study reviewed the advantages and disadvantages of transperineal prostate biopsy (TP-bx) and evaluated its potential to become the standard of care for prostate biopsy. Research findings suggested that TP-bx and transrectal biopsy (TR-bx) had similar prostate cancer detection rates, but TP-bx may have an increased detection rate for anterior prostate tumors. The use of anesthetic techniques has eliminated the need for sedation during TP-bx, making it a cost-effective office-based procedure.

CURRENT UROLOGY REPORTS (2023)

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Article Oncology

Comprehensive analysis of complications after transperineal prostate biopsy without antibiotic prophylaxis: results of a multicenter trial with 30 days' follow-up

Tobias Kohl et al.

Summary: This study investigated infectious and non-infectious complications after transperineal prostate biopsy (TPB) without antibiotic prophylaxis, finding that an increased number of cores was associated with an increase in overall complications, specifically bleeding complications, but not with infectious complications. Post-biopsy erectile dysfunction was mainly present in patients diagnosed with prostate cancer.

PROSTATE CANCER AND PROSTATIC DISEASES (2022)

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Article Infectious Diseases

Antibiotic prophylaxis versus no antibiotic prophylaxis in transperineal prostate biopsies (NORAPP): a randomised, open-label, non-inferiority trial

Maciej Jacewicz et al.

LANCET INFECTIOUS DISEASES (2022)

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Editorial Material Infectious Diseases

Is it time to abandon routine antibiotics for transperineal prostate biopsy?

Ola Bratt

LANCET INFECTIOUS DISEASES (2022)

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Review Urology & Nephrology

Nonantibiotic Strategies for the Prevention of Infectious Complications following Prostate Biopsy: A Systematic Review and Meta-Analysis

Benjamin Pradere et al.

Summary: The study identified that transperineal biopsy reduces infectious complications compared to transrectal biopsy, while rectal preparation with povidone-iodine is effective in reducing infections and hospitalization post-prostate biopsy. Other investigated nonantibiotic strategies did not have a significant impact on infection or hospitalization outcomes.

JOURNAL OF UROLOGY (2021)

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Article Oncology

Sectoral cancer detection and tolerability of freehand transperineal prostate biopsy under local anaesthesia

Peter Ka-Fung Chiu et al.

Summary: A total of 611 patients underwent freehand transperineal prostate biopsies under local anesthesia. The study found that omitting basal sector biopsies had minimal impact on the detection of high-grade prostate cancer. The procedure was well tolerated with minimal sepsis risk and low post-biopsy fever occurrence.

PROSTATE CANCER AND PROSTATIC DISEASES (2021)

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Article Urology & Nephrology

The negative aftermath of prostate biopsy: prophylaxis, complications and antimicrobial stewardship: results of the global prevalence study of infections in urology 2010-2019

Jakhongir F. Alidjanov et al.

Summary: The study found that the rates of complications after P-Bx tended to increase over time, as well as the rates of patients seeking additional medical help in the post-P-Bx period. To reduce the risk of infectious complications and to comply with the principles of antibiotic stewardship, clinicians should switch to the transperineal biopsy route.

WORLD JOURNAL OF UROLOGY (2021)

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Article Urology & Nephrology

Infective Complications After Prostate Biopsy: Outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, A Prospective Multinational Multicentre Prostate Biopsy Study

Florian M. E. Wagenlehner et al.

EUROPEAN UROLOGY (2013)

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Article Urology & Nephrology

Systematic transperineal ultrasound-guided template biopsy of the prostate: Three-year experience

DM Pinkstaff et al.

UROLOGY (2005)

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Antimicrobial prophylaxis: To do or not to do? This is the question

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