4.7 Article

WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease

Joshua Stevenson-Hoare et al.

Summary: Plasma biomarkers for Alzheimer's disease-related pathologies have made significant progress in recent years, with well-validated blood tests available for the detection of amyloid and tau pathology, as well as neurodegeneration and astrocytic activation. This study demonstrates that a combination of five plasma biomarkers, along with genetic variants associated with these biomarkers, can be used to accurately diagnose and predict the onset of Alzheimer's disease.
Article Geriatrics & Gerontology

Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes

Adam J. Dugan et al.

Summary: The genetic locus containing the WWOX and MAF genes is implicated in neurological changes, specifically limbic-predominant age-related TDP-43 encephalopathy neuropathological changes, hippocampal sclerosis, and brain arteriolosclerosis, but not with Alzheimer's disease neuropathological changes.

NEUROBIOLOGY OF AGING (2022)

Article Clinical Neurology

Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel A Meta-analysis

Brian W. Kunkle et al.

Summary: This study identified additional Alzheimer disease risk loci in African American individuals, indicating that the disease risk in this population differs from other ethnic groups.

JAMA NEUROLOGY (2021)

Review Clinical Neurology

Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects

Srinivasarao Repudi et al.

Summary: WWOX-related epileptic encephalopathy (WOREE) syndrome is a neurodevelopmental disorder caused by bi-allelic mutations in the WWOX gene, leading to symptoms such as intractable epilepsy and developmental delay. Studies in mice and human brain organoids have shown evidence of myelination defects and hyperexcitability associated with WWOX function.
Article Genetics & Heredity

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease

Ganqiang Liu et al.

Summary: A genome-wide survival study identified variants at RIMS2 associated with progression of Parkinson's disease to dementia and highlights divergence in the genetic architecture of disease onset and progression.

NATURE GENETICS (2021)

Review Biochemistry & Molecular Biology

Neuroinflammation-Associated Alterations of the Brain as Potential Neural Biomarkers in Anxiety Disorders

Eunsoo Won et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders

C. Marcelo Aldaz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Sarah Jakel et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Loss of Wwox Causes Defective Development of Cerebral Cortex with Hypomyelination in a Rat Model of Lethal Dwarfism with Epilepsy

Yuki Tochigi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

WWOX, the FRA16D gene: A target of and a contributor to genomic instability

Tabish Hussain et al.

GENES CHROMOSOMES & CANCER (2019)

Article Gastroenterology & Hepatology

Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease

Marijn C. Visschedijk et al.

JOURNAL OF CROHNS & COLITIS (2018)

Article Multidisciplinary Sciences

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

Andrew T. McKenzie et al.

SCIENTIFIC REPORTS (2018)

Review Behavioral Sciences

Aggression, Social Stress, and the Immune System in Humans and Animal Models

Aki Takahashi et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2018)

Article Multidisciplinary Sciences

Loss of Wwox drives metastasis in triple-negative breast cancer by JAK2/STAT3 axis

Renxu Chang et al.

NATURE COMMUNICATIONS (2018)

Review Neurosciences

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration

Chan-Chuan Liu et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Anatomy & Morphology

The Absolute Number of Oligodendrocytes in the Adult Mouse Brain

Bruna Valerio-Gomes et al.

FRONTIERS IN NEUROANATOMY (2018)

Article Biochemistry & Molecular Biology

Wwox-Brca1 interaction: role in DNA repair pathway choice

M. S. Schrock et al.

ONCOGENE (2017)

Article Physiology

Loss of lung WWOX expression causes neutrophilic inflammation

Sunit Singla et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

Review Multidisciplinary Sciences

Maternal immune activation: Implications for neuropsychiatric disorders

Myka L. Estes et al.

SCIENCE (2016)

Review Cell Biology

Microglia: Architects of the Developing Nervous System

Jeffrey L. Frost et al.

TRENDS IN CELL BIOLOGY (2016)

Article Oncology

Tumor Suppressor WWOX Moderates the Mitochondrial Respiratory Complex

Amanda Choo et al.

GENES CHROMOSOMES & CANCER (2015)

Article Biochemistry & Molecular Biology

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation

M. Abu-Remaileh et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Cardiac & Cardiovascular Systems

The WWOX Gene Modulates High-Density Lipoprotein and Lipid Metabolism

Iulia Iatan et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2014)

Article Multidisciplinary Sciences

Conditional Wwox Deletion in Mouse Mammary Gland by Means of Two Cre Recombinase Approaches

Brent W. Ferguson et al.

PLOS ONE (2012)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Review Immunology

Inflammation in neurodegenerative diseases

Sandra Amor et al.

IMMUNOLOGY (2010)

Review Immunology

The Role of the Transcription Factor CREB in Immune Function

Andy Y. Wen et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Genetics & Heredity

WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels

Jenny C. Lee et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2008)

Review Neurosciences

From inflammation to sickness and depression: when the immune system subjugates the brain

Robert Dantzer et al.

NATURE REVIEWS NEUROSCIENCE (2008)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

JH Ludes-Meyers et al.

ONCOGENE (2004)

Review Cell Biology

Transcriptional regulation by the phosphorylation-dependent factor CREB

B Mayr et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)