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Christy Hong et al.
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STING agonist promotes CAR T cell trafficking and in breast cancer
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Cancer cell-intrinsic STING is associated with CD8+T-cell infiltration and might serve as a potential immunotherapeutic target in hepatocellular carcinoma
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TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
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STING enhances cell death through regulation of reactive oxygen species and DNA damage
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Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C
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The cGAS-STING pathway as a therapeutic target in inflammatory diseases
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STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
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The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer
John Kwon et al.
CANCER DISCOVERY (2020)
TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
Katherine R. Balka et al.
CELL REPORTS (2020)
Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma
Lihong Wang-Bishop et al.
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STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
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NATURE CELL BIOLOGY (2020)
Molecular mechanisms and cellular functions of cGAS-STING signalling
Karl-Peter Hopfner et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Crosstalk between cGAS-STING signaling and cell death
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Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
Mengze Lv et al.
CELL RESEARCH (2020)
STEEP mediates STING ER exit and activation of signaling
Bao-cun Zhang et al.
NATURE IMMUNOLOGY (2020)
EGFR-mediated tyrosine phosphorylation ofSTINGdetermines its trafficking route and cellular innate immunity functions
Chenyao Wang et al.
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DNA Damage and Cancer Immunotherapy: A STING in the Tale
Timo Reislander et al.
MOLECULAR CELL (2020)
The interactions between cGAS-STING pathway and pathogens
Zhangliang Cheng et al.
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The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-κ2B signaling and STING's dual role during MCMV infection
Markus Stempel et al.
EMBO JOURNAL (2019)
STING-associated lung disease in mice relies on T cells but not type I interferon
Hella Luksch et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
Jianjun Wu et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Xiang Gui et al.
NATURE (2019)
Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer
Triparna Sen et al.
CANCER DISCOVERY (2019)
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer
Constantia Pantelidou et al.
CANCER DISCOVERY (2019)
STING: a master regulator in the cancer-immunity cycle
Yuanyuan Zhu et al.
MOLECULAR CANCER (2019)
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
Hiroshi Maekawa et al.
CELL REPORTS (2019)
STIM1 moonlights as an anchor for STING
Jianjun Wu et al.
NATURE IMMUNOLOGY (2019)
The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
Sonal Srikanth et al.
NATURE IMMUNOLOGY (2019)
Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles
Shannon Grabosch et al.
ONCOGENE (2019)
Responses to Cytokines and Interferons that Depend upon JAKs and STATs
George R. Stark et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)
The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer
Tuo Li et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression
Jing Nan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Kelsey E. Sivick et al.
CELL REPORTS (2018)
Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling
Isabelle Melki et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)
A noncanonical function of cGAMP in inflammasome priming and activation
Karen V. Swanson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
STING-associated vasculopathy develops independently of IRF3 in mice
James D. Warner et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
Immune Diseases Associated with TREX1 and STING Dysfunction
Nan Yan
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2017)
Mitotic progression following DNA damage enables pattern recognition within micronuclei
Shane M. Harding et al.
NATURE (2017)
Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections
Wenshi Wang et al.
SCIENCE SIGNALING (2017)
Signalling strength determines proapoptotic functions of STING
Muhammet F. Gulen et al.
NATURE COMMUNICATIONS (2017)
Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections
Wenshi Wang et al.
SCIENCE SIGNALING (2017)
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt et al.
CELL (2017)
Ubiquitination of STING at lysine 224 controls IRF3 activation
Guoxin Ni et al.
SCIENCE IMMUNOLOGY (2017)
JAK inhibition in STING-associated interferonopathy
Mathieu P Rodero et al.
ANNALS OF THE RHEUMATIC DISEASES (2016)
STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection
Xin Wang et al.
CELL HOST & MICROBE (2016)
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
Wei-Wei Luo et al.
NATURE IMMUNOLOGY (2016)
Activation of STING requires palmitoylation at the Golgi
Kojiro Mukai et al.
NATURE COMMUNICATIONS (2016)
Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis
Tianli Xia et al.
CELL REPORTS (2016)
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
Nicole Dobbs et al.
CELL HOST & MICROBE (2015)
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
Olivier Demaria et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Siqi Liu et al.
SCIENCE (2015)
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
Surya Pandey et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
STING: infection, inflammation and cancer
Glen N. Barber
NATURE REVIEWS IMMUNOLOGY (2015)
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
Nadia Jeremiah et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Activated STING in a Vascular and Pulmonary Syndrome
Y. Liu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
HyeonJoo Cheon et al.
EMBO JOURNAL (2013)
Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ
Nikolay Burnaevskiy et al.
NATURE (2013)
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
Qian Yin et al.
MOLECULAR CELL (2012)
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
Yasuo Tanaka et al.
SCIENCE SIGNALING (2012)
STING is a direct innate immune sensor of cyclic di-GMP
Dara L. Burdette et al.
NATURE (2011)
STAT2 Contributes to Promotion of Colorectal and Skin Carcinogenesis
Ana M. Gamero et al.
CANCER PREVENTION RESEARCH (2010)
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Hiroki Ishikawa et al.
NATURE (2009)
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Hiroki Ishikawa et al.
NATURE (2008)
An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
Ralph R. Weichselbaum et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
STAT2 nuclear trafficking
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)