期刊
JOURNAL OF VIROLOGY
卷 90, 期 10, 页码 5200-5204出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.03174-15
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资金
- Wellcome Trust [097997/Z/11/Z]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/I012303/1, BB/J001708/1]
- Ministry of Science, ICT and Future Planning (MSIP) [2014R1A2A2A01004292]
- Marie Curie Cancer Care [628373]
- Biotechnology and Biological Sciences Research Council [BB/I012303/2, BB/I012303/1, BB/N001176/1, BB/J001708/1] Funding Source: researchfish
- BBSRC [BB/I012303/1, BB/I012303/2, BB/N001176/1, BB/J001708/1] Funding Source: UKRI
The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that unwinds RNA structure in the 5' untranslated region (UTR) of mRNAs. Here, we investigated the role of eIF4A in porcine sapovirus VPg-dependent translation. Using inhibitors and dominant-negative mutants, we found that eIF4A is required for viral translation and infectivity, suggesting that despite the presence of a very short 5' UTR, eIF4A is required to unwind RNA structure in the sapovirus genome to facilitate virus translation.
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