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Viruses and amyloids-a vicious liaison

PRION (2023)

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Article Clinical Neurology

Rapidly evolving Creutzfeldt-Jakob disease in COVID-19: from early status epilepticus to fatal outcome

Sasha Olivo et al.

Summary: We present a case of a 70-year-old man who developed rapidly progressing CJD with SARS-CoV-2 co-infection, ultimately leading to his death after 15 days of hospitalization. This rare clinical presentation highlights the challenges in diagnosis.

ACTA NEUROLOGICA BELGICA (2023)

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Article Neurosciences

Virus exposure and neurodegenerative disease risk across national biobanks

Kristin S. Levine et al.

NEURON (2023)

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Letter Medicine, General & Internal

Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke

Nicholas J. J. Reish et al.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

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Review Geriatrics & Gerontology

Poliomyelitis is a current challenge: long-term sequelae and circulating vaccine-derived poliovirus

Jorge Quarleri

Summary: The World Health Organization Western Pacific Region has been free of polio for over 20 years, but two challenges remain. Firstly, elderly polio survivors experience late polio sequelae that greatly affect their daily lives and quality of life. Secondly, vaccine-derived poliovirus strains are circulating and pose a significant obstacle to polio elimination. Maintaining high vaccination rates and improving living conditions in poorer nations are crucial for eradicating polio.

GEROSCIENCE (2023)

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Editorial Material Pharmacology & Pharmacy

COVID-19 Neurologic Manifestations

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

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Article Multidisciplinary Sciences

Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells

Razie Amraei et al.

Summary: Vimentin (VIM) is identified as an important attachment factor for SARS-CoV-2 on human endothelial cells. Exogenous VIM binds to the SARS-CoV-2 spike protein and facilitates viral infection. Co-expression of VIM increases SARS-CoV-2 entry in HEK-293 cells, while knockdown of VIM reduces virus infection in human endothelial cells. In addition, binding of VIM with the CR3022 antibody inhibits viral entry, suggesting a key role for VIM in SARS-CoV-2 infection of endothelial cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Review Endocrinology & Metabolism

Impact of COVID-19 on the Endocrine System: A Mini-review

Sophie A. Clarke et al.

Summary: This review summarizes the effects of COVID-19 on various endocrine axes to guide appropriate investigations and optimal management.

ENDOCRINOLOGY (2022)

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Review Biochemistry & Molecular Biology

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

Douglas B. Kell et al.

Summary: Post-acute sequelae of COVID, commonly known as Long COVID, is a frequent consequence of SARS-CoV-2 infection. Fibrin amyloid microclots may underpin the majority of symptoms by blocking capillaries and limiting oxygen exchange.

BIOCHEMICAL JOURNAL (2022)

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Article Chemistry, Multidisciplinary

Amyloidogenesis of SARS-CoV-2 Spike Protein

Sofie Nystrom et al.

Summary: SARS-CoV-2 infection is associated with various morbidities. The spike protein of SARS-CoV-2 shows similarities to amyloid-disease associated blood coagulation and fibrinolytic disturbances, as well as neurologic and cardiac problems. Through experiments, researchers identified seven amyloidogenic sequences within the spike protein, and found that synthetic spike peptides can form amyloid-like fibrils when co-incubated with the protease neutrophil elastase. These findings suggest a potential molecular mechanism for amyloidogenesis of SARS-CoV-2 spike protein, which may be important in understanding COVID-19 disease-associated pathogenesis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Multidisciplinary Sciences

SARS-CoV-2 is associated with changes in brain structure in UK Biobank

Gwenaelle Douaud et al.

Summary: Through long-term observation of participants' MRI images, it was found that COVID-19 infection is associated with abnormal brain changes, including a reduction in gray matter thickness in the orbitofrontal cortex and parahippocampal gyrus, greater changes in markers of tissue damage in regions functionally connected to the primary olfactory cortex, and a greater reduction in global brain size. Infected individuals also showed significant cognitive decline.

NATURE (2022)

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Review Biochemistry & Molecular Biology

Unexplained post-acute infection syndromesUnexplained post-acute infection syndromes

Jan Choutka et al.

Summary: Unexplained post-acute infection syndromes (PAISs) represent a group of chronic illnesses with overlapping clinical features with chronic fatigue syndrome (ME/CFS). This review summarizes the current knowledge of PAISs and discusses the need for basic biomedical research into the underlying mechanisms of these enigmatic chronic diseases, including the post-acute sequelae of SARS-CoV-2 infection (PASC).

NATURE MEDICINE (2022)

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Article Cell Biology

Challenges and directions in studying cell-cell communication by extracellular vesicles

Guillaume van Niel et al.

Summary: Extracellular vesicles (EVs) play a significant role in cell-cell communication, but there are still many questions regarding their delivery in vivo. This article highlights the progress and challenges in understanding the importance of EV-mediated communication and provides recommendations for addressing these issues.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Endocrinology & Metabolism

Risk of incident diabetes post-COVID-19: A systematic review and meta-analysis

Mainak Banerjee et al.

Summary: It remains unclear whether newly diagnosed diabetes during acute COVID-19 persists in the post-acute COVID phase. This meta-analysis aimed to summarize available literature and estimate the risk of developing incident diabetes following hospital discharge or at least 28 days after COVID-19 diagnosis. The analysis showed a 59% higher risk of developing incident diabetes in the post-acute COVID-19 phase compared to healthy controls. Similar results were observed when comparing COVID-19 to severity matched non-COVID-19 respiratory tract infections.

PRIMARY CARE DIABETES (2022)

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Article Multidisciplinary Sciences

Medin co-aggregates with vascular amyloid-β in Alzheimer's disease

Jessica Wagner et al.

Summary: Medin amyloid aggregates in blood vessels and co-localizes with vascular amyloid-beta deposits. MFGE8 expression levels are associated with cognitive decline in Alzheimer's disease patients. Medin interacts directly with amyloid-beta to promote its aggregation.

NATURE (2022)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection and persistence in the human body and brain at autopsy

Sydney B. Stein et al.

Summary: This study provides new insights into the extent of COVID-19 infection in patients. It reveals that SARS-CoV-2 can be widely distributed throughout the body, including the brain, and can persist for up to 230 days, particularly in severe cases.

NATURE (2022)

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Article Neurosciences

Association of COVID-19 with New-Onset Alzheimer's Disease

Lindsey Wang et al.

Summary: This retrospective cohort study found that COVID-19 infection is associated with an increased risk of Alzheimer's disease, particularly in older adults and women.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Article Hematology

The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1

Claire S. Whyte et al.

Summary: This study investigates the dysregulation of the fibrinolytic system in COVID-19 disease and finds that elevated levels of PAI-1 suppress plasmin generation, leading to suboptimal fibrinolysis. These findings have important implications for the treatment and prognostic potential of COVID-19 disease.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

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Article Biochemistry & Molecular Biology

Creutzfeldt-Jakob disease after COVID-19: infection-induced prion protein misfolding? A case report

Andrea Bernardini et al.

Summary: This article describes a case of a young patient developing Creutzfeldt-Jakob disease (CJD) two months after mild COVID-19. The patient initially presented with visuospatial deficits and ataxia, which progressed to being bedridden with myoclonus. The diagnostic work-up suggested CJD. This case highlights the potential link between neuroinflammation and protein misfolding, and further studies are needed to establish the role of SARS-CoV-2 in neurodegeneration.

PRION (2022)

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Article Neurosciences

A postmortem study suggests a revision of the dual-hit hypothesis of Parkinson's disease

Per Borghammer et al.

Summary: The dual-hit hypothesis of Parkinson's disease suggests that a neurotropic pathogen leads to formation of alpha-synuclein pathology that enters the brain from the olfactory bulb and the dorsal motor nucleus of the vagus. However, a re-analysis of postmortem datasets found that early body-first Lewy body disease (LBD) cases rarely had olfactory bulb pathology, while early brain-first LBD cases almost always showed olfactory bulb pathology. This supports the idea that the pathological process starts in either the olfactory bulb or the enteric nervous system, but not both simultaneously.

NPJ PARKINSONS DISEASE (2022)

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Article Multidisciplinary Sciences

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

Saba Islam et al.

Summary: The authors report the presence of toxic clumps of protein in the COVID-19 virus that resemble amyloid assemblies found in Alzheimer's disease. They suggest that these clumps may play a role in the neurological symptoms observed in long-COVID.

NATURE COMMUNICATIONS (2022)

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Article Hematology

Amyloidosis and COVID-19: experience from an amyloid program in Canada

Ellen Lewis et al.

Summary: Patients with amyloidosis are likely to be at a high risk of severe COVID-19 infection and mortality, especially those who are older, undergoing chemotherapy, or have concomitant B-cell or plasma cell disorders. Further research is needed to investigate the impact of virtual healthcare visits and pandemic measures on the observed excess deaths.

ANNALS OF HEMATOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system

Arneaux Kruger et al.

Summary: Post-acute sequelae of COVID-19 (PASC), also known as long COVID, has become a global health and economic burden. The most challenging aspect of this condition is that traditional pathology tests may not detect the presence of insoluble fibrin amyloid microclots and the trapped inflammatory molecules. A study found that long COVID patients have symptoms such as constant fatigue, cognitive impairment, depression, and anxiety. The presence of pro-inflammatory molecules and significant platelet hyperactivation in these patients suggests a failed fibrinolytic system and potential implications for individuals with comorbidities.

CARDIOVASCULAR DIABETOLOGY (2022)

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Article Clinical Neurology

Aβ Deposits in the Neocortex of Adult and Infant Hypoxic Brains, Including in Cases of COVID-19

David S. Priemer et al.

Summary: This study found unusual A beta deposits in the brain of a woman who died due to COVID-19, as well as in the brains of other young COVID-19 patients. These deposits, which may be linked to hypoxia, could potentially contribute to neurocognitive sequelae observed in some COVID-19 patients.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2022)

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Article Biochemistry & Molecular Biology

Long-term neurologic outcomes of COVID-19

Evan Xu et al.

Summary: Individuals with COVID-19 have an increased risk of developing a range of neurologic disorders at 12 months, even if they were not hospitalized during the acute phase of the infection.

NATURE MEDICINE (2022)

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Article Immunology

Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults

Joseph Fraiman et al.

Summary: This study found that mRNA COVID-19 vaccines are associated with an excess risk of serious adverse events, emphasizing the need for formal harm-benefit analyses, particularly those stratified according to risk of serious COVID-19 outcomes.

VACCINE (2022)

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Review Clinical Neurology

Genetic aspects of human prion diseases

Brian S. Appleby et al.

Summary: This article reviews the genetic aspects of human prion disease, including the impact of genetic variations on the disease and the related epidemiology, clinicopathologic phenotype, diagnostics, clinical management, and potential treatment approaches.

FRONTIERS IN NEUROLOGY (2022)

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Article Immunology

A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19

Michael Moerz

Summary: This report presents a case of a 76-year-old man with Parkinson's disease who died three weeks after receiving his third COVID-19 vaccination. Post-mortem examinations confirmed Parkinson's disease and revealed signs of aspiration pneumonia and systemic arteriosclerosis. Histopathological analyses showed acute vasculitis and multifocal necrotizing encephalitis in the brain, as well as chronic cardiomyopathy and myocarditis in the heart. Immunohistochemistry testing detected only spike protein in the inflammation foci of the brain and the heart, suggesting the presence of spike protein is due to vaccination rather than viral infection.

VACCINES (2022)

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Article Biochemistry & Molecular Biology

Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee

Joel N. Buxbaum et al.

Summary: The Nomenclature Committee of the International Society of Amyloidosis has proposed a nomenclature recommendation, adding six new proteins to the list of human amyloid fibril proteins, including intracellular amyloid fibrils associated with neurodegenerative diseases.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2022)

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Article Clinical Neurology

Association of herpes zoster with dementia and effect of antiviral therapy on dementia: a population-based cohort study

Seongman Bae et al.

Summary: The study revealed that patients with herpes zoster have a higher risk of dementia, but this risk can be reduced by receiving antiviral therapy.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2021)

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Review Cell Biology

Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning

Daniel J. Drucker

Summary: The increased prevalence of obesity, diabetes, and cardiovascular risk factors in severe COVID-19 patients has sparked interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology. This update focuses on how metabolic disorders and their co-morbidities affect susceptibility, natural history, and treatment of SARS-CoV-2 infection in individuals with obesity and diabetes. New data on genetics, epidemiology, immune responses, disease severity, and therapy are highlighted, informing our understanding of COVID-19 in this vulnerable population.

CELL METABOLISM (2021)

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Review Biochemistry & Molecular Biology

Mechanisms and therapeutic potential of interactions between human amyloids and viruses

Emiel Michiels et al.

Summary: Research has shown that amyloids can encode important cellular functions, one of which involves interaction with microbial pathogens, including viruses. Amyloids expressed in humans can act as both innate restriction molecules against viruses and agents that promote viral infectivity. The underlying molecular driving forces of amyloid-virus interactions are not completely understood at present.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Chemistry, Multidisciplinary

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes

Danilo Milardi et al.

Summary: The possible link between hIAPP accumulation and beta-cell death in diabetic patients has sparked a lot of research on amyloid structures and aggregation pathways. Recent studies have highlighted the importance of early oligomeric intermediates and their interactions with lipid membranes, pH, insulin, and zinc in the mechanism of hIAPP aggregation. Challenges in characterizing the aggregation process have led to the development of various biophysical and chemical approaches, with studies suggesting that restoring hIAPP proteostasis could be a promising strategy for therapy.

CHEMICAL REVIEWS (2021)

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Review Chemistry, Medicinal

HBsAg, Subviral Particles, and Their Clearance in Establishing a Functional Cure of Chronic Hepatitis B Virus Infection

Andrew Vaillant

Summary: Excessive production of spherical subviral particles (SVP) in chronic HBV infection is a commonly observed immune evasion mechanism that inhibits immune response and contributes to the chronic nature of HBV infection. The goal of current therapies for HBV infection is to achieve functional cure, which is challenging due to the distinct mechanisms of SVP assembly, secretion, and persistence. Current therapies struggle to target these mechanisms effectively, making the clearance of SVP a rare outcome.

ACS INFECTIOUS DISEASES (2021)

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Review Medicine, General & Internal

Cardiac Complications in COVID-19: A Systematic Review and Meta-analysis

Mehrdad Sahranavard et al.

Summary: This study systematically reviewed cardiac complications in COVID-19 patients, finding pooled incidence rates of 10.11% for arrhythmia, 17.85% for myocardial injury, and 22.34% for heart failure. The pooled level of unadjusted cTnI was significantly higher in expired cases compared with surviving cases.

ARCHIVES OF IRANIAN MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Herpes simplex virus encoded ICP6 protein forms functional amyloid assemblies with necroptosis-associated host proteins

Nirukshan Shanmugam et al.

Summary: The ICP6 viral protein has a RHIM structure that can interact with host proteins to form amyloid complexes, potentially serving as a general mechanism for viral adaptation against host immune responses.

BIOPHYSICAL CHEMISTRY (2021)

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Article Medicine, General & Internal

Herpes simplex viruses (1 and 2) and varicella-zoster virus infections in an adult population with aseptic meningitis or encephalitis A nine-year retrospective clinical study

Gha-Hyun Lee et al.

Summary: This study aimed to assess the clinical manifestations, laboratory findings, and outcomes in patients with HSV-1, HSV-2, and VZV CNS infections. It found that HSV-1 infection was commonly associated with encephalitis and poor prognosis, while HSV-2 and VZV infections were associated with a low risk of mortality and neurological sequelae.

MEDICINE (2021)

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Review Pathology

Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution

Yuki Tateishi et al.

Summary: The study reviewed 131 autopsy cases of amyloidosis to identify the Japanese characteristics of each type. Results showed that the transthyretin type was significantly associated with certain patterns, while the AA type showed different associations. About 90% of cases were successfully classified using commercially available antibodies.

PATHOLOGY RESEARCH AND PRACTICE (2021)

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Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

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Article Multidisciplinary Sciences

Causes of death and comorbidities in hospitalized patients with COVID-19

Sefer Elezkurtaj et al.

Summary: The study conducted autopsies on 26 patients who died after SARS-CoV-2 infection and COVID-19, finding that septic shock and multi organ failure were the most common immediate causes of death, often due to suppurative pulmonary infection. Most patients had comorbidities such as hypertension, ischemic heart disease, and obesity. The majority of deaths were found to be directly related to COVID-19, with contributory implications of preexisting health conditions to the mechanism of death.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Shu Liu et al.

Summary: Protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells via extracellular vesicles or direct cell-to-cell contact. The study shows that viral glycoproteins can contribute to intercellular proteopathic seed transmission via both routes.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Serum Amyloid A in Inflammatory Rheumatic Diseases: A Compendious Review of a Renowned Biomarker

Iva Soric Hosman et al.

Summary: SAA plays a central role in the pathogenesis of inflammatory rheumatic diseases (IRD) by activating the inflammasome cascade and recruiting interleukin 17 producing T helper cells. Although overshadowed by markers like CRP and ESR, recent studies have shown the potential of SAA as a sensitive biomarker in predicting and monitoring response to biological immunotherapy in IRD patients. Additionally, SAA has emerged as a biomarker for severe COVID-19, suggesting its potential in disease management and development of new therapeutic strategies.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Clinical and Radiological Deterioration in a Case of Creutzfeldt-Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration

Dumitru Ciolac et al.

Summary: This study describes a case of an elderly female patient with Creutzfeldt-Jakob disease (CJD) who experienced clinical deterioration and neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. Despite efforts to control the disease progression, a poor outcome was observed. The report suggests a vulnerability to CJD and increased CJD progression following COVID-19, indicating age-dependent neurological effects of SARS-CoV-2 infection.

BIOMEDICINES (2021)

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Review Cardiac & Cardiovascular Systems

Fundamentals in Covid-19-Associated Thrombosis: Molecular and Cellular Aspects

Daniella M. Mizurini et al.

Summary: COVID-19 infection is associated with a high incidence of coagulopathy and venous thromboembolism, characterized by increased D-dimer levels and release of inflammatory cytokines that activate vascular cells leading to a prothrombotic state. The review summarizes the cellular mechanisms proposed for the establishment of COVID-19-associated thrombosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Editorial Material Biochemistry & Molecular Biology

Likelihood of amyloid formation in COVID-19-induced ARDS

Nabodita Sinha et al.

Summary: Severe COVID-19 infection can cause ARDS with limited therapeutic success, and the pathophysiology of ARDS or post-ARDS is not well understood. The hypothesis suggests that amyloid formation due to disruption of protein homeostasis may be a complication associated with COVID-19-induced ARDS.

TRENDS IN MICROBIOLOGY (2021)

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Article Clinical Neurology

COVID-19-associated encephalitis or Creutzfeldt-Jakob disease: a case report

Gooya Tayyebi et al.

Summary: The COVID-19 pandemic has posed challenges to the accurate diagnosis and management of patients with rapidly progressive dementia, but making a timely and accurate diagnosis of Creutzfeldt-Jakob disease can help patients receive good healthcare and avoid extensive evaluations for other conditions.

NEURODEGENERATIVE DISEASE MANAGEMENT (2021)

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Article Biochemistry & Molecular Biology

Protease resistance of ex vivo amyloid fibrils implies the proteolytic selection of disease-associated fibril morphologies

Jonathan Schoenfelder et al.

Summary: Recent studies have shown that ex vivo fibrils are more protease stable than in vitro fibrils, supporting the proteolytic selection hypothesis. These findings help explain why only a few amino acid sequences lead to amyloid diseases.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2021)

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Article Biochemistry & Molecular Biology

Old dog, new tricks: Influenza A virus NS1 and in vitro fibrillogenesis

A. A. Shaldzhyan et al.

Summary: The influenza NS1 protein can form amyloid-like fibrils in vitro, with significant structural changes occurring during fibril formation. A protein fragment capable of inducing fibrillogenesis was also discovered, suggesting a potential relationship between influenza A infection and modulation of the immune response.

BIOCHIMIE (2021)

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Article Cardiac & Cardiovascular Systems

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

Etheresia Pretorius et al.

Summary: Individuals with Long COVID/PASC may exhibit persistent symptoms due to the presence of persistent circulating plasma microclots that are resistant to fibrinolysis, including fatigue, shortness of breath, sleep issues, and anxiety or depression.

CARDIOVASCULAR DIABETOLOGY (2021)

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Article Biochemistry & Molecular Biology

PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice

Christophe Chevalier et al.

Summary: In this study, researchers investigated the correlation between PB1-F2 protein structures and the resulting inflammatory response in influenza A virus-infected mice. The results showed a proinflammatory effect of PB1-F2 fibers compared to other forms of the protein, leading to respiratory distress. This suggests that the virulence mechanisms of PB1-F2 may depend on its sequence and oligomerization status.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Virology

Zika virus capsid anchor forms cytotoxic amyloid-like fibrils

Kumar Udit Saumya et al.

Summary: The study investigated the amyloid-forming propensity of the Capsid-anchor protein of Zika virus at physiological conditions, revealing the formation of characteristic amyloid-like fibrils with beta-sheet secondary structure and cytotoxic nature on mammalian cells.

VIROLOGY (2021)

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Review Cell Biology

Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections

Maximilian Hirschenberger et al.

Summary: Non-persistent viruses can cause post-acute sequelae (PAS) leading to persistent or new symptoms in patients after the acute phase. Immune dysregulation and chronic inflammation may play key roles in the development of PAS associated with non-persistent viral infections.

CELLS (2021)

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Review Clinical Neurology

Frequency of Neurologic Manifestations in COVID-19 A Systematic Review and Meta-analysis

Shubham Misra et al.

Summary: Up to one-third of patients with COVID-19 experienced at least one neurologic manifestation in this review. 1 in 50 patients experienced stroke. In patients over 60 years of age, more than one-third had acute confusion/delirium; the presence of neurologic manifestations in this group was associated with nearly a doubling of mortality.

NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

Hypothesis: AA amyloidosis is a factor causing systemic complications after coronavirus disease

Alexey P. Galkin

Summary: Severe COVID-19 leads to systemic chronic inflammation and thrombosis, with high levels of cytokines triggering overproduction of Serum amyloid A protein, potentially causing systemic AA amyloidosis.

PRION (2021)

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Article Medicine, General & Internal

Long-term sequelae following previous coronavirus epidemics

Oliver O'Sullivan

Summary: Both survivors of SARS and MERS faced chronic problems, which could provide insights for the medical planning for survivors of COVID-19, particularly focusing on cardiopulmonary sequelae, fatigue, and psychological burden.

CLINICAL MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Causes of AA amyloidosis: a systematic review

Anne Floor Brunger et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2020)

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Article Pharmacology & Pharmacy

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Canrong Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Article Biochemistry & Molecular Biology

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

Furong Qi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Cell Biology

Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

Thomas Menter et al.

HISTOPATHOLOGY (2020)

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Article Critical Care Medicine

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

Julie Helms et al.

INTENSIVE CARE MEDICINE (2020)

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Article Cell Biology

Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins

Tobias Langenberg et al.

CELL REPORTS (2020)

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Article Urology & Nephrology

Acute kidney injury in patients hospitalized with COVID-19

Jamie S. Hirsch et al.

KIDNEY INTERNATIONAL (2020)

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Article Medicine, General & Internal

Multiorgan and Renal Tropism of SARS-CoV-2

Victor G. Puelles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Gastroenterology & Hepatology

Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis

Ren Mao et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

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Review Endocrinology & Metabolism

Endocrine Significance of SARS-CoV-2's Reliance on ACE2

Eric Lazartigues et al.

ENDOCRINOLOGY (2020)

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Article Immunology

Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?

Michael J. Young et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

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Review Biochemistry & Molecular Biology

Extrapulmonary manifestations of COVID-19

Aakriti Gupta et al.

NATURE MEDICINE (2020)

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Review Virology

Silencing and Transcriptional Regulation of Endogenous Retroviruses: An Overview

Franziska K. Geis et al.

VIRUSES-BASEL (2020)

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Article Microbiology

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death

Megan Steain et al.

PLOS PATHOGENS (2020)

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Review Biochemistry & Molecular Biology

Comprehensive Review on Alzheimer's Disease: Causes and Treatment

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MOLECULES (2020)

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Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study

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LANCET RHEUMATOLOGY (2020)

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Review Clinical Neurology

A Narrative Review of the Role of Transthyretin in Health and Disease

Marcia Almeida Liz et al.

NEUROLOGY AND THERAPY (2020)

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Review Cell Biology

Endoplasmic reticulum: a focal point of Zika virus infection

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JOURNAL OF BIOMEDICAL SCIENCE (2020)

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Article Cell & Tissue Engineering

Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study

Peixun Zhang et al.

BONE RESEARCH (2020)

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Article Materials Science, Biomaterials

Amyloid Fibrils with Positive Charge Enhance Retroviral Transduction in Mammalian Cells

Sneha Kirti et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Materials Science, Biomaterials

Amyloid Fibrils with Positive Charge Enhance Retroviral Transduction in Mammalian Cells

Sneha Kirti et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Neurosciences

Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer's disease?

Tamas Fulop et al.

JOURNAL OF NEUROVIROLOGY (2019)

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Review Clinical Neurology

Genetics of amyotrophic lateral sclerosis: A review

Stephane Mathis et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2019)

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Article Evolutionary Biology

Molecular Chaperones Accelerate the Evolution of Their Protein Clients in Yeast

David Alvarez-Ponce et al.

GENOME BIOLOGY AND EVOLUTION (2019)

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The viral protein corona directs viral pathogenesis and amyloid aggregation

Kariem Ezzat et al.

NATURE COMMUNICATIONS (2019)

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Review Biochemical Research Methods

Fibrinogen alpha amyloidosis: insights from proteomics

Jessica Chapman et al.

EXPERT REVIEW OF PROTEOMICS (2019)

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Article Multidisciplinary Sciences

Proteostasis collapse is a driver of cell aging and death

Mantu Santra et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

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Article Psychiatry

Depression as a Mediator of Chronic Fatigue and Post-Traumatic Stress Symptoms in Middle East Respiratory Syndrome Survivors

So Hee Lee et al.

PSYCHIATRY INVESTIGATION (2019)

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Article Biochemistry & Molecular Biology

Plasminogen activation triggers transthyretin amyloidogenesis in vitro

P. Patrizia Mangione et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

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Article Psychology, Clinical

Herpes Zoster and Dementia: A Nationwide Population-Based Cohort Study

Vincent Chin-Hung Chen et al.

JOURNAL OF CLINICAL PSYCHIATRY (2018)

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Article Clinical Neurology

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections-a Nationwide, Population-Based Cohort Study in Taiwan

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NEUROTHERAPEUTICS (2018)

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Article Multidisciplinary Sciences

Enhancement of Ebola virus infection by seminal amyloid fibrils

Stephen M. Bart et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Biochemistry & Molecular Biology

Human Endogenous Retroviruses in Neurological Diseases

Patrick Kuery et al.

TRENDS IN MOLECULAR MEDICINE (2018)

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Pseudotyping exosomes for enhanced protein delivery in mammalian cells

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Immunology

Neurological Implications of Zika Virus Infection in Adults

Laura S. Munoz et al.

JOURNAL OF INFECTIOUS DISEASES (2017)

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Article Multidisciplinary Sciences

Influence of C-terminal truncation of murine Serum amyloid A on fibril structure

Matthies Rennegarbe et al.

SCIENTIFIC REPORTS (2017)

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Semen amyloids participate in spermatozoa selection and clearance

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ELIFE (2017)

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Article Immunology

Human Coronavirus-HKU1 Infection Among Adults in Cleveland, Ohio

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OPEN FORUM INFECTIOUS DISEASES (2017)

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Increased risk of dementia following herpes zoster ophthalmicus

Ming-Chieh Tsai et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders

Yasmin Zeinolabediny et al.

SCIENTIFIC REPORTS (2017)

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Article Hematology

VLITL is a major cross-β-sheet signal for fibrinogen Aα-chain frameshift variants

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BLOOD (2017)

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Review Biochemistry & Molecular Biology

Functional Amyloids in Reproduction

Aveline Hewetson et al.

BIOMOLECULES (2017)

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Familial Mediterranean fever, review of the literature

Mansour Alghamdi

CLINICAL RHEUMATOLOGY (2017)

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The spectrum of neuropathological changes associated with congenital Zika virus infection

Leila Chimelli et al.

ACTA NEUROPATHOLOGICA (2017)

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DnaK-Dependent Accelerated Evolutionary Rate in Prokaryotes

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GENOME BIOLOGY AND EVOLUTION (2016)

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Mammalian prions and their wider relevance in neurodegenerative diseases

John Collinge

NATURE (2016)

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Review Multidisciplinary Sciences

Defects in trafficking bridge Parkinson's disease pathology and genetics

Asa Abeliovich et al.

NATURE (2016)

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Distinctive proteomic profiles among different regions of human carotid plaques in men and women

Wenzhao Liang et al.

SCIENTIFIC REPORTS (2016)

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Review Medicine, General & Internal

Systematic review of the literature on viral persistence and sexual transmission from recovered Ebola survivors: evidence and recommendations

Anna Thorson et al.

BMJ OPEN (2016)

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MALDI-Mass Spectrometry Imaging Identifies Vitronectin as a Common Constituent of Amyloid Deposits

Martin Winter et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2015)

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Article Biochemistry & Molecular Biology

Hsp90 Promotes Kinase Evolution

Jennifer Lachowiec et al.

MOLECULAR BIOLOGY AND EVOLUTION (2015)

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Review Biochemistry & Molecular Biology

Assembly, stability and dynamics of virus capsids

Mauricio G. Mateu

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2013)

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Infection of the central nervous system caused by varicella zoster virus reactivation: a retrospective case series study

Juan Carlos Lozano Becerra et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2013)

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Article Clinical Neurology

Intensity of human prion disease surveillance predicts observed disease incidence

Genevieve M. J. A. Klug et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2013)

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Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

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LANCET INFECTIOUS DISEASES (2013)

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Review Infectious Diseases

HIV-associated neurocognitive disorder

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LANCET INFECTIOUS DISEASES (2013)

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Review Biochemistry & Molecular Biology

Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention

James P. Solomon et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Amyloid Fibrils Trigger the Release of Neutrophil Extracellular Traps (NETs), Causing Fibril Fragmentation by NET-associated Elastase

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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Article Dermatology

A Novel Form of Amyloid Deposited at the Site of Enfuvirtide Injection

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JOURNAL OF CUTANEOUS PATHOLOGY (2012)

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Review Biotechnology & Applied Microbiology

Non-canonical translation in RNA viruses

Andrew E. Firth et al.

JOURNAL OF GENERAL VIROLOGY (2012)

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Article Biochemistry & Molecular Biology

Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness

Jacinte Beerten et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2012)

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Article Microbiology

Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection

Nadia R. Roan et al.

CELL HOST & MICROBE (2011)

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Article Biotechnology & Applied Microbiology

Protein Transfer Into Human Cells by VSV-G-induced Nanovesicles

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MOLECULAR THERAPY (2011)

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Modeling familial British and Danish dementia

Holly J. Garringer et al.

BRAIN STRUCTURE & FUNCTION (2010)

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Editorial Material Pharmacology & Pharmacy

Enfuvirtide: from basic investigations to current clinical use

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EXPERT OPINION ON PHARMACOTHERAPY (2010)

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PB1-F2 Influenza A Virus Protein Adopts a β-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments

Christophe Chevalier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Review Virology

Herpesviruses and Chromosomal Integration

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JOURNAL OF VIROLOGY (2010)

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Mental Morbidities and Chronic Fatigue in Severe Acute Respiratory Syndrome Survivors Long-term Follow-up

Marco Ho-Bun Lam et al.

ARCHIVES OF INTERNAL MEDICINE (2009)

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Article Oncology

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

M. A. Wozniak et al.

JOURNAL OF PATHOLOGY (2009)

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Anterograde Spread of Herpes Simplex Virus Type 1 Requires Glycoprotein E and Glycoprotein I but Not Us9

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JOURNAL OF VIROLOGY (2009)

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Article Multidisciplinary Sciences

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

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SCIENCE (2009)

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Article Clinical Neurology

The varicella zoster virus vasculopathies -: Clinical, CSF, imaging, and virologic features

M. A. Nagel et al.

NEUROLOGY (2008)

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Article Biochemistry & Molecular Biology

Semen-derived amyloid fibrils drastically enhance HIV infection

Jan Muench et al.

CELL (2007)

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Letter Hematology

Increased plasmin-α2-antiplasmin levels indicate activation of the fibrinolytic system in systemic amyloidoses

B. Bouma et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)

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Letter Biochemistry & Molecular Biology

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

Gian Gaetano Tartaglia et al.

TRENDS IN BIOCHEMICAL SCIENCES (2007)

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Article Hematology

Association of acquired von Willebrand syndrome with AL amyloidosis

Cynthia A. Kos et al.

AMERICAN JOURNAL OF HEMATOLOGY (2007)

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Letter Hematology

Prevalence and pathology of amyloid in atherosclerotic arteries

C Röcken et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Review Biochemistry & Molecular Biology

Prion disease genetics

S Mead

EUROPEAN JOURNAL OF HUMAN GENETICS (2006)

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Article Biochemistry & Molecular Biology

How evolutionary pressure against protein aggregation shaped chaperone specificity

F Rousseau et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

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The importance of sequence diversity in the aggregation and evolution of proteins

CF Wright et al.

NATURE (2005)

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Article Biochemistry & Molecular Biology

Amyloid accomplices and enforcers

Andrei T. Alexandrescu

PROTEIN SCIENCE (2004)

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Review Biochemistry & Molecular Biology

Conformational constraints for amyloid fibrillation: the importance of being unfolded

VN Uversky et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)

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Article Multidisciplinary Sciences

Sequence-dependent denaturation energetics:: A major determinant in amyloid disease diversity

P Hammarström et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Article Biochemistry & Molecular Biology

Tissue-type plasminogen activator is a multiligand cross-β structure receptor

O Kranenburg et al.

CURRENT BIOLOGY (2002)

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Article Hematology

Life-threatening bleeding and acquired factor V deficiency associated with primary systemic amyloidosis

Y Emori et al.

BLOOD COAGULATION & FIBRINOLYSIS (2002)

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Article Multidisciplinary Sciences

Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation

JS Richardson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

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Article Hematology

Bleeding symptoms and coagulation abnormalities in 337 patients with AL-amyloidosis

AD Mumford et al.

BRITISH JOURNAL OF HAEMATOLOGY (2000)

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Article Biochemistry & Molecular Biology

Large conformational changes in the maturation of a simple RNA virus, Nudaurelia capensis ω virus (NωV)

MA Canady et al.

JOURNAL OF MOLECULAR BIOLOGY (2000)

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Review Clinical Neurology

Cerebral amyloid angiopathy: An overview

M Yamada

NEUROPATHOLOGY (2000)

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