4.5 Article

Fat mass index and airway hyperresponsiveness in Korean adults

期刊

POSTGRADUATE MEDICINE
卷 135, 期 5, 页码 480-485

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/00325481.2023.2188000

关键词

Asthma; airway hyperresponsiveness; body composition; fat mass; muscle mass; obesity

向作者/读者索取更多资源

This study investigated the effect of changes in fat mass on the development of asymptomatic airway hyperresponsiveness (AHR) in adults. The results showed that a rapid gain of fat mass over time may be a risk factor for the development of AHR. Further prospective studies are needed to confirm the results and evaluate the role of fat mass reduction in preventing AHR development in obese adults.
ObjectiveAirway hyperresponsiveness (AHR) is associated with asthma and obesity, which is defined as a high body mass index. Body mass mainly comprises fat mass (FM) and muscle mass (MM), which are independent of each other. We investigated the effect of changes in FM over time on the development of asymptomatic AHR in adults.MethodsThis long-term longitudinal study included adults who were underwent health checkups at the Seoul National University Hospital Gangnam Center. The participants underwent two methacholine bronchial provocation tests with a follow-up period (between the first and second tests) of more than 3 years and bioelectrical impedance analysis (BIA) at all visits. FM index (FMI; FM normalized for height) and MM index (MMI; MM normalized for height) were calculated using BIA.ResultsThe study included 328 adult participants (61 women and 267 men). The mean number of BIA measurements was 6.96 and the follow-up duration was 6.69 years. In total, 13 participants showed a positive conversion of AHR. Multivariate analysis indicated that a high rate of change in FMI ([g/m(2)]/year), not MMI, was significantly associated with the risk of AHR development (P = 0.037) after adjustment for age, sex, smoking status, and FEV1 predicted.ConclusionA rapid gain of FM over time may be a risk factor for developing AHR in adults. Prospective studies are needed to confirm our results and evaluate the role of FM reduction in preventing AHR development in obese adults.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据