期刊
JOURNAL OF VIRAL HEPATITIS
卷 24, 期 1, 页码 75-79出版社
WILEY
DOI: 10.1111/jvh.12621
关键词
antibody dynamics; anti-HEV IgG; hepatitis E virus; negative seroconversion; reinfection
Hepatitis E virus (HEV) is highly endemic in industrialized countries, but there is a lack of knowledge on individual and overall antibody concentration dynamics. The aim of this study was to characterize longitudinal concentration changes of anti-HEV immunoglobulin G (anti-HEV IgG) by enzyme immunoassay (EIA). In total, 199 serum samples collected from 45 subjects over 18years were analysed. A wide range of anti-HEV IgG levels was found. Overall, anti-HEV IgG significantly decreased after an observation period of at least 5years. One negative seroconversion was observed. Four individual profiles suggested single and even multiple HEV reinfections despite pre-existing HEV antibodies.
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