Mapping CircRNA-miRNA-mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 infection

Article Biochemistry & Molecular Biology

miRTarBase update 2022: an informative resource for experimentally validated miRNA-target interactions

Hsi-Yuan Huang et al.

Summary: miRTarBase is a large biological database that provides experimentally verified miRNA-target interactions, making it one of the most research-friendly MTI databases with comprehensive and experimentally verified annotations.

NUCLEIC ACIDS RESEARCH (2022)

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Review Virology

The cytokine storm and COVID-19

Biying Hu et al.

Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Review Biochemistry & Molecular Biology

The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents

Faryal Mehwish Awan et al.

Summary: circRNAs, formed by back-splicing of pre-mRNAs, show high stability and resistance to degradation, which may have potential therapeutic applications. Despite their diverse biological roles, the circular structure and sequence overlap with linear mRNA counterparts make circRNAs challenging to study in depth, especially their involvement in viral infections and immune responses. Understanding circRNA-mediated viral protein regulations could enhance knowledge of these novel molecules and their implications for antiviral immunity and therapy.

RNA BIOLOGY (2021)

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Article Ophthalmology

circRNA-miRNA-mRNA network in age-related macular degeneration: From construction to identification

Yu Su et al.

Summary: This study aimed to investigate the pathogenesis of age-related macular degeneration (AMD) by constructing a regulatory circRNA-miRNA-mRNA network. Through network analysis, a potential regulation axis of hsa_circRNA7329/hsa-miR-9/SCD was identified, suggesting a role in promoting inflammation and pathologic angiogenesis in AMD development. Further investigation is required to elucidate the underlying mechanisms.

EXPERIMENTAL EYE RESEARCH (2021)

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Article Multidisciplinary Sciences

Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium

Rajaneesh K. Gupta et al.

Summary: Drug repurposing strategy was used to identify potential drugs for COVID-19 treatment by analyzing differentially expressed genes related to SARS-CoV-2 infection. A total of 15 potential novel drug candidates were identified among 283 differentially expressed genes, showing promise for effective intervention against the ongoing pandemic.

PLOS ONE (2021)

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Article Virology

Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection

Yajie Hu et al.

Summary: In this study, RNA sequencing was used to characterize the expression of circRNAs during EV-A71 infection, identifying key circRNAs associated with the progression of viral infection.

VIRUS RESEARCH (2021)

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Article Biology

Longitudinal proteomic profiling of dialysis patients with COVID-19 reveals markers of severity and predictors of death

Jack Gisby et al.

Summary: Analysis of blood samples from ESKD patients with COVID-19 revealed protein markers associated with clinical severity, including epithelial damage, immune activation, and cell-cell interactions, providing potential drug targets.

ELIFE (2021)

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Article Multidisciplinary Sciences

Diosmectite inhibits the interaction between SARS-CoV-2 and human enterocytes by trapping viral particles, thereby preventing NF-kappaB activation and CXCL10 secretion

Marco Poeta et al.

Summary: The study shows that Diosmectite can alleviate COVID-19-associated diarrhea by binding SARS-CoV-2 components and inhibiting inflammation, suggesting it as a potential management option for this symptom.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

Role of miR-2392 in driving SARS-CoV-2 infection

J. Tyson McDonald et al.

Summary: The research demonstrates that miR-2392 is associated with SARS-CoV-2 infection, with potential for use in COVID-19 detection and as a target for antiviral therapy. Targeting miR-2392 can significantly reduce SARS-CoV-2 viability, indicating a potential treatment for COVID-19.

CELL REPORTS (2021)

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Article Medicine, General & Internal

HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study

Rita Bergqvist et al.

Summary: This cohort study in Stockholm residents found a modest negative association between statin treatment and COVID-19 mortality. The association did not vary significantly across different age groups, genders, or COVID-19 risk groups. Further confirmation from randomized clinical trials is needed, but this study supports the continued use of statin treatment for medical prevention during the COVID-19 pandemic.

PLOS MEDICINE (2021)

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Article Infectious Diseases

Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2

Mengmei Yang et al.

Summary: The study revealed that during SARS-CoV-2 infection, the dynamic expression and functions of circRNAs changed, particularly in immune and inflammatory responses. Dysregulated circRNAs could regulate gene stability, immunity, and cell death by binding RNA binding proteins, and indirectly modulate gene expression by absorbing miRNAs.

INFECTION GENETICS AND EVOLUTION (2021)

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Article Biology

Unraveling the molecular crosstalk between Atherosclerosis and COVID-19 comorbidity

Deepyaman Das et al.

Summary: There is a molecular link between atherosclerosis and COVID-19, with inflammation being a common factor in both diseases. Through analysis of transcription factors and target genes, MYD88 is identified as a crucial factor linking the two diseases.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 infection initiates interleukin-17-enriched transcriptional response in different cells from multiple organs

Md Zobaer Hasan et al.

Summary: The study identified key genes and pathways uniquely associated with SARS-CoV-2 infection by analyzing publicly available RNA-seq datasets. Of note, the activation of the IL-17 signaling pathway was particularly strong in SARS-CoV-2 infection compared with other respiratory viruses. The transcriptomic signature was also analyzed to predict potential drug repurposing and small molecule inhibitors.

SCIENTIFIC REPORTS (2021)

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Article Microbiology

Altered microRNA expression in COVID-19 patients enables identification of SARS-CoV-2 infection

Ryan J. Farr et al.

Summary: This study analyzed the host miRNA response to COVID-19 and identified a three-miRNA signature that can independently classify COVID-19 cases with high accuracy. The findings suggest that miRNA profiling could potentially improve COVID-19 detection and patient management.

PLOS PATHOGENS (2021)

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Article Oncology

Blood DNA methylation and COVID-19 outcomes

Joseph Balnis et al.

Summary: The study compared DNA CpG methylation in blood samples from COVID-19 patients and healthy controls collected before the pandemic, revealing differentially methylated regions associated with acute illness and autoimmune disorders. The results also showed a correlation between hyper-methylation in COVID-19 patients and worse outcomes, suggesting that DNA methylation may influence the expression of genes that regulate COVID-19 progression.

CLINICAL EPIGENETICS (2021)

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Article Multidisciplinary Sciences

AHR signaling is induced by infection with coronaviruses

Federico Giovannoni et al.

Summary: It has been found that coronaviruses activate AHR signaling, potentially impacting antiviral immunity and lung epithelial cells. The activation of AHR by coronaviruses is a common strategy to evade antiviral immunity and promote viral replication. This suggests that AHR could be a target for host-directed antiviral therapy.

NATURE COMMUNICATIONS (2021)

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Article Medicine, General & Internal

Differential expression of miRNAs in a human developing neuronal cell line chronically infected with Zika virus

Omar Bagasra et al.

Summary: This research uncovers the impact of ZIKV infection on miRNAs dysregulations in neurons, potentially leading to neurological disorders. Specific miRNAs were found significantly upregulated or downregulated, highlighting their crucial role in ZIKV infection. Target gene alignment of these miRNAs with the ZIKV genome provides insights into their functions and potential directions for further research.

LIBYAN JOURNAL OF MEDICINE (2021)

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Article Mathematical & Computational Biology

Circular RNA-MicroRNA-MRNA interaction predictions in SARS-CoV-2 infection

Yilmaz Mehmet Demirci et al.

Summary: Different types of noncoding RNAs, such as miRNAs and circRNAs, play important roles in various cellular processes including gene regulation during infection. Human miRNAs may be involved in host-pathogen interactions and target viral mRNAs, such as SARS-CoV-2, as a potential antiviral defense mechanism. Machine learning approaches can be used to predict differential expression patterns of human miRNAs during SARS-CoV-2 infection.

JOURNAL OF INTEGRATIVE BIOINFORMATICS (2021)

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Article Multidisciplinary Sciences

IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression

Sujan K. Dhar et al.

Summary: This study conducted a comprehensive meta-analysis to establish the association between induced cytokines and COVID-19 disease severity, focusing on 13 cytokines identified from 18 clinical studies. The results showed that IL-6 and IL-10 had statistically significant standardized mean differences across studies, and a classifier built using the mean values of both cytokines as covariates had an accuracy of around 92%, outperforming previous literature using them as individual covariates.

HELIYON (2021)

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Article Biochemistry & Molecular Biology

miRDB: an online database for prediction of functional microRNA targets

Yuhao Chen et al.

NUCLEIC ACIDS RESEARCH (2020)

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Review Biotechnology & Applied Microbiology

Revealing new landscape of cardiovascular disease through circular RNA-miRNA-mRNA axis

Qiang Su et al.

GENOMICS (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Review Allergy

Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19

Ahmet Kursat Azkur et al.

ALLERGY (2020)

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Article Biochemistry & Molecular Biology

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo et al.

CELL (2020)

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Editorial Material Cell Biology

COVID-19: treating and managing severe cases

Jingwen Ai et al.

CELL RESEARCH (2020)

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Article Immunology

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

Chuan Qin et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Allergy

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

Yang Yang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Clinical and immunological features of severe and moderate coronavirus disease 2019

Guang Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Immunology

RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection

Lu Shuang et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Genetics & Heredity

Long Non-coding RNAs Involved in Pathogenic Infection

Shintaro Shirahama et al.

FRONTIERS IN GENETICS (2020)

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Article Medicine, General & Internal

Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients

Jin Liu et al.

EBIOMEDICINE (2020)

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Article Cell Biology

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Yadi Zhou et al.

CELL DISCOVERY (2020)

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Review Microbiology

Circular RNAs: New Epigenetic Signatures in Viral Infections

Javid Sadri Nahand et al.

FRONTIERS IN MICROBIOLOGY (2020)

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Review Immunology

Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past

Vibhuti Kumar Shah et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Immunology

Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China

Ying Chi et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Letter Neurosciences

Clomipramine Could Be Useful in Preventing Neurological Complications of SARS-CoV-2 Infection

B. Nobile et al.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2020)

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Article Immunology

Long-term infection of SARS-CoV-2 changed the body's immune status

Lan Lin et al.

CLINICAL IMMUNOLOGY (2020)

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Article Virology

The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for Comorbidities

Elif Damla Arisan et al.

VIRUSES-BASEL (2020)

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Article Biochemistry & Molecular Biology

Intussusceptive angiogenesis in Covid-19: hypothesis on the significance and focus on the possible role of FGF2

Simone Meini et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Biochemistry & Molecular Biology

An inflammatory cytokine signature predicts COVID-19 severity and survival

Diane Marie Del Valle et al.

NATURE MEDICINE (2020)

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Article Genetics & Heredity

Prediction and Analysis of SARS-CoV-2-Targeting MicroRNA in Human Lung Epithelium

Jonathan Tak-Sum Chow et al.

GENES (2020)

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Article Genetics & Heredity

Unravelling host-pathogen interactions: ceRNA network in SARS-CoV-2 infection (COVID-19)

Shweta Arora et al.

GENE (2020)

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Review Virology

Non-Coding RNAs and SARS-Related Coronaviruses

Hanna Henzinger et al.

VIRUSES-BASEL (2020)

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Article Chemistry, Medicinal

Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles

Catherine Z. Chen et al.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Circbank: a comprehensive database for circRNA with standard nomenclature

Ming Liu et al.

RNA BIOLOGY (2019)

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Review Immunology

The Opening of Pandora's Box: An Emerging Role of Long Noncoding RNA in Viral Infections

Pin Wang

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, Research & Experimental

Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus

Shanxin Peng et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

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Review Virology

LncRNA, miRNA and lncRNA-miRNA interaction in viral infection

Linlin Chen et al.

VIRUS RESEARCH (2018)

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miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9

Jie Song et al.

EMERGING MICROBES & INFECTIONS (2018)

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Review Genetics & Heredity

On the Importance of Host MicroRNAs During Viral Infection

Erika Girardit et al.

FRONTIERS IN GENETICS (2018)

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Review Genetics & Heredity

Diagnostic and Prognostic Value of MicroRNA in Viral Diseases

Eeva Auvinen

MOLECULAR DIAGNOSIS & THERAPY (2017)

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Review Oncology

An emerging function of circRNA-miRNAs-mRNA axis in human diseases

Dawei Rong et al.

ONCOTARGET (2017)

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CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs

Dawood B. Dudekulay et al.

RNA BIOLOGY (2016)

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Long noncoding RNAs in viral infections

Puri Fortes et al.

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Downregulation of microRNA-637 Increases Risk of Hypoxia-Induced Pulmonary Hypertension by Modulating Expression of Cyclin Dependent Kinase 6 (CDK6) in Pulmonary Smooth Muscle Cells

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MEDICAL SCIENCE MONITOR (2016)

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Viral noncoding RNAs: more surprises

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Predicting effective microRNA target sites in mammalian mRNAs

Vikram Agarwal et al.

ELIFE (2015)

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Inhibition of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by HIV-1 Nef and Cellular MicroRNA hsa-miR-1258

Qin Yan et al.

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Evidence for a crucial role of a host non-coding RNA in influenza A virus replication

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NCBI GEO: archive for functional genomics data sets-update

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Viruses, microRNAs, and Host Interactions

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miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1

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miRDB: A microRNA target prediction and functional annotation database with a wiki interface

Xiaowei Wang

RNA (2008)

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MicroRNAs and viral infection

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Cytoscape: A software environment for integrated models of biomolecular interaction networks

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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

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KEGG: Kyoto Encyclopedia of Genes and Genomes

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NUCLEIC ACIDS RESEARCH (2000)

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Mapping CircRNA-miRNA-mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 infection

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