FOXP1 inhibits pancreatic cancer growth by transcriptionally regulating IRF1 expression

FOXP1, known as a Forkhead-box (FOX) family protein, plays an important role in human tumorigenesis. However, the function and molecular mechanism of FOXP1 in pancreatic cancer (PC) remain unclear. Here, we report that PC patients with FOXP1 overexpression had a higher survival rate compared to patients with low- FOXP1 expression. Additionally, high expression of FOXP1 can markedly inhibit the growth of pancreatic cancer in vivo and in vitro, whereas low expression of FOXP1 effectively promoted the tumorigenesis. Mechanistically, FOXP1 could directly bind the IRF1 promoter, which triggered the transcriptional activity of IRF1. Taken together, FOXP1 suppressed PC growth via IRF1-dependent manner, serving as a potential prognostic biomarker for patients with PC.

Automated summary

FOXP1 overexpression is associated with a higher survival rate in pancreatic cancer patients. High expression of FOXP1 inhibits pancreatic cancer growth, while low expression of FOXP1 promotes tumorigenesis. FOXP1 suppresses pancreatic cancer growth via an IRF1-dependent pathway and could serve as a potential prognostic biomarker for pancreatic cancer patients.