☆ 4.6 Article

Hydroxycamptothecin regulates scar formation of the filtration channel under scleral flap by inhibiting the proliferation of scleral fibroblasts

PLOS ONE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Immunology

Protectin DX promotes the inflammatory resolution via activating COX-2/ L-PGDS-PGD2 and DP1 receptor in acute respiratory distress syndrome

Xin Hu et al.

Summary: This study found that PDX promotes the resolution of inflammation in ARDS models by enhancing the expression of the secondary peak of COX-2/L-PGDS-PGD2 and activating the DP1 receptor. This suggests that PDX has promising therapeutic potential in the clinical management of ARDS.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Differential response to hypoxia in leiomyoma and myometrial cells

Mariko Miyashita-Ishiwata et al.

Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.

LIFE SCIENCES (2022)

添加到收藏夹

Article Plant Sciences

Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer

Jin-hua Fan et al.

Summary: The study confirmed that the main ingredients of Zuojin Capsules can target multiple genes to combat colorectal cancer. The results provide a basis for future clinical trials.

PHYTOMEDICINE (2022)

添加到收藏夹

Article Cell Biology

WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia

Yunqi Zhu et al.

Summary: WTIP, a potential tumor suppressor, is significantly reduced in AML, and low levels of WTIP are associated with decreased overall survival in AML patients. Overexpression of WTIP inhibits cell proliferation and induces apoptosis through the transcriptional activation of FOXO3a.

CELL DEATH & DISEASE (2022)

添加到收藏夹

Article Cell Biology

LncRNA TUG1 promotes bladder cancer malignant behaviors by regulating the miR-320a/FOXQ1 axis

Jing Tan et al.

Summary: The study showed that TUG1 is upregulated in bladder cancer and promotes malignant behaviors of BC cells by acting as a sponge for miR-320a, providing a potential therapeutic target for BC.

CELLULAR SIGNALLING (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Effect of oral statin use on mitomycin-C augmented trabeculectomy outcomes

Abhibol Inobhas et al.

Summary: This study found that oral statin use was associated with higher rates of trabeculectomy failure, as well as increased numbers of 5-FU injections and bleb-needling procedures.

PLOS ONE (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Phenylboronic Acid-Modified Polyamidoamine Mediated the Transfection of Polo-Like Kinase-1 siRNA to Achieve an Anti-Tumor Efficacy

Gu Gong et al.

Summary: The phenylboronic acid-modified polyamidoamine (PP) was used as a carrier for delivering Polo-like kinase-1 siRNA, leading to a significant anti-tumor response in hepatocarcinoma cells. The PP/siPlk-1 nanoparticles exhibited strong anti-proliferation effects and could efficiently suppress the migration and invasion of tumor cells. The derivative PP holds great potential as an ideal tumor-targeting carrier for gene therapy in malignant tumors.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

添加到收藏夹

Article Cell Biology

Involvement of METTL3/m(6)Adenosine and TGF beta/Smad3 signaling on Tenon's fibroblasts and in a rabbit model of glaucoma surgery

Yan Liu et al.

Summary: The study revealed the importance of N-6-methyladenosine (m(6)A) in the process of glaucoma filtration surgery (GFS), with METTL3 playing a role in modulating Smad3 in TGF-beta 1-induced HTFs, providing novel theoretical strategies for inhibiting scar formation after GFS.

JOURNAL OF MOLECULAR HISTOLOGY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Identification and Heterologous Expression of the Kendomycin B Biosynthetic Gene Cluster from Verrucosispora sp. SCSIO 07399

Jiang Chen et al.

Summary: SCSIO07399 strain of Verrucosispora sp. produces ansamycin-like polyketides kendomycin B-D with potent antibacterial activities and moderate tumor cytotoxicity. The biosynthetic gene cluster for kendomycin B was identified, and the essential role of the kmy cluster in biosynthesis was confirmed through gene disruption and heterologous expression. Insights into kendomycin B biosynthesis were gained and a foundation was set for further research into exploiting the carbacylic ansa scaffold.

MARINE DRUGS (2021)

添加到收藏夹

Article Ophthalmology

Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision

Rumi Kawashima et al.

Summary: In this study, the safety and efficiency of 5-flourouracil (5-FU) as an adjunctive anti-metabolite in Infrared monitor-guided bleb revision (IRGBR) for failing filtering blebs were evaluated. The use of adjunctive 5-FU in IRGBR led to a higher success rate for failing trabeculectomy blebs. Risk factors for failure included no use of 5-FU and intraocular pressure (IOP) >= 10 mmHg 1 week after IRGBR.

BMC OPHTHALMOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb

Ai Kido et al.

Summary: Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels and can be used to evaluate changes in blood vessels post-trabeculectomy. CAAs were detected in most cases after surgery and their extent decreased over time, but they were not significantly associated with surgical success. Using OCTA for objective evaluation of bleb vascularity may be helpful.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract

Haiyang Wu et al.

Summary: The gut symbiont Ruminococcus gnavus strain-specific glycoside hydrolases GH98 shows strict specificity for blood group A tetrasaccharide, enabling colonization in different nutritional niches in the human gut and potential applications in diagnostic and therapeutic interventions against infection.

PLOS BIOLOGY (2021)

添加到收藏夹

Article Food Science & Technology

The Antagonistic Effect of Glutamine on Zearalenone-Induced Apoptosis via PI3K/Akt Signaling Pathway in IPEC-J2 Cells

Tianhu Wang et al.

Summary: The study demonstrated that Glutamine exhibited significant protective effects on Zearalenone-induced cytotoxicity in IPEC-J2 cells, potentially through activation of the PI3K/Akt signaling pathway.

TOXINS (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

A novel GSH-triggered polymeric nanomicelles for reversing MDR and enhancing antitumor efficiency of hydroxycamptothecin

Lanlan Zong et al.

Summary: A bio-responsive anti-drug-resistant polymer micelle was designed to deliver HCPT in the tumor microenvironment, showing improved anti-tumor activity, biosafety, and reversal of drug resistance. This nanoplatform can serve as a flexible and powerful system for delivery of other drugs tolerated by tumors or bacteria.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Article Ophthalmology

MuLLER CELL CONE-ASSOCIATED FOVEAL DETACHMENT AS A RISK FACTOR FOR VISUAL ACUITY LOSS AFTER GLAUCOMA FILTERING SURGERY

Etsuo Chihara et al.

Summary: Hypotony-associated foveal lesions were found to be significant risk factors for visual acuity loss after trabeculectomy, with detachment of photoreceptors and acquired vitelliform lesions being common manifestations. The presence of foveal lesions was associated with lower visual acuity at 3 and 12 months post-surgery, indicating the long-lasting impact of Muller cell cone-associated foveal lesions on visual function.

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES (2021)

添加到收藏夹

Article Engineering, Biomedical

Combating liver cancer through GO-targeted biomaterials

Xing Huang et al.

Summary: Hydroxycamptothecin (HCPT) is a topoisomerase I inhibitor widely used in the treatment of primary liver cancer and gastric cancer, but its clinical application is limited by water solubility. This study developed a GO-CMC-HA/HCPT drug delivery system to enhance HCPT uptake in HepG-2 cells, leading to inhibition of proliferation and improved efficacy in vivo and in vitro.

BIOMEDICAL MATERIALS (2021)

添加到收藏夹

Article Biophysics

Sustained-Release Hydrogel-Based Rhynchophylline Delivery System Improved Injured Tendon Repair

Qian Qian Yang et al.

Summary: The study demonstrates that Rhy has a good therapeutic effect by inhibiting adhesion formation, promoting tendon healing, and improving tendon function. Rhy can regulate tendon cell and collagen growth through multiple pathways, showing great potential for the treatment of tendon injuries.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

添加到收藏夹

Article Surgery

USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar-Derived Fibroblasts by Deubiquitinating TGF-βR1 In Vitro

Longxiang Tu et al.

Summary: Hypertrophic scars are fibroproliferative disorders caused by skin injury. USP15 enhances the functions of hypertrophic scar-derived fibroblasts, including proliferation, migration, invasion, and collagen deposition, by deubiquitinating T beta RI.

PLASTIC AND RECONSTRUCTIVE SURGERY (2021)

添加到收藏夹

Article Emergency Medicine

Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts

Jie Li et al.

Summary: MicroRNA-101 (miR-101) is a tumor suppressor microRNA associated with various diseases, but its role in hypertrophic scars (HS) remained unclear. Research showed that low miR-101 expression in HS and HSF, overexpressing miR-101 reduced collagen expression in HSF, while high EZH2 expression was detected in HS and HSF. MiR-101 targeted EZH2 to suppress collagen deposition in HS.

BURNS & TRAUMA (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Design, synthesis and in vitro evaluation of fangchinoline derivatives as potential anticancer agents

Yan-chun Zhang et al.

BIOORGANIC CHEMISTRY (2020)

添加到收藏夹

Editorial Material Ophthalmology

Reporting Complications in Glaucoma Surgery: A Systematic Review

Alan Kastner et al.

OPHTHALMOLOGY (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Extracellular vesicles from hydroxycamptothecin primed umbilical cord stem cells enhance anti-adhesion potential for treatment of tendon injury

Juehong Li et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Adipose tissue-derived stem cells inhibit hypertrophic scar (HS) fibrosis via p38/MAPK pathway

Chi-Yung Chai et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hydroxycamptothecin Prevents Fibrotic Pathways in Fibroblasts In Vitro

Zhixiao Yao et al.

IUBMB LIFE (2019)

添加到收藏夹

Review Medicine, General & Internal

Current management of glaucoma

Jed Lusthaus et al.

MEDICAL JOURNAL OF AUSTRALIA (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Hydroxycamptothecin Inhibits Peritendinous Adhesion via the Endoplasmic Reticulum Stress-Dependent Apoptosis

Zhixiao Yao et al.

FRONTIERS IN PHARMACOLOGY (2019)

添加到收藏夹

Article Oncology

(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

Mengqiu Song et al.

CANCERS (2019)

添加到收藏夹

Article Pharmacology & Pharmacy

Hydroxycamptothecin induces apoptosis of fibroblasts and prevents intraarticular scar adhesion in rabbits by activating the IRE-1 signal pathway

Xiaolei Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Effect of Hydroxycamptothecin on Wound Healing Following Reduction of the Knee Intra-Articular Adhesion in Rabbits

Lianqi Yan et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2015)

添加到收藏夹

Article Ophthalmology

MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon's capsule fibroblasts upon hydroxycamptothecin exposure

Xinyu Xu et al.

EXPERIMENTAL EYE RESEARCH (2014)

添加到收藏夹

Article Ophthalmology

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040 A Systematic Review and Meta-Analysis

Yih-Chung Tham et al.

OPHTHALMOLOGY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells

Xue-mei Wu et al.

ACTA PHARMACOLOGICA SINICA (2011)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.