Review: A silent concert in developing plants: Dynamic assembly of cullin-RING ubiquitin ligases

Plants appear quiet: quietly, they break the ground, expand leaves, search for resources, alert each other to invaders, and heal their own wounds. In contrast to the stationary appearance, the inside world of a plant is full of movements: cells divide to increase the body mass and form new organs; signaling molecules migrate among cells and tissues to drive transcriptional cascades and developmental programs; macromolecules, such as RNAs and proteins, collaborate with different partners to maintain optimal organismal function under changing cellular and environmental conditions. All these activities require a dynamic yet appropriately controlled mo-lecular network in plant cells. In this short review, we used the regulation of cullin-RING ubiquitin ligases (CRLs) as an example to discuss how dynamic biochemical processes contribute to plant development. CRLs comprise a large family of modular multi-unit enzymes that determine the activity and stability of diverse regulatory pro-teins playing crucial roles in plant growth and development. The mechanism governing the dynamic assembly of CRLs is essential for CRL activity and biological function, and it may provide insights and implications for the regulation of other dynamic multi-unit complexes involved in fundamental processes such as transcription, translation, and protein sorting in plants.

Automated summary

Plants may seem quiet on the surface, but inside, there are various dynamic activities happening, such as cell division, signaling molecule migration, and macromolecule collaboration. These activities require a dynamic yet controlled molecular network. This article uses the regulation of cullin-RING ubiquitin ligases as an example to discuss how dynamic biochemical processes contribute to plant development.