Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling

Article Plant Sciences

Baicalin suppresses the progression of Type 2 diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Capase3 pathway

Hongpeng Jiang et al.

Summary: Baicalin can suppress the progression of T2D-induced liver tumors by regulating the METTL3/m(6)A/HKDC1 axis, indicating its potential application in prevention and treatment of T2D-induced liver cancer.

PHYTOMEDICINE (2022)

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Article Biophysics

Meningioma-associated protein 30 accelerates the proliferation and invasion of hepatocellular carcinoma by modulating Wnt/GSK-3β/β-catenin signaling

Yu Zhang et al.

Summary: MAC30 is upregulated in HCC tissues and cell lines, promoting proliferation and invasion of HCC cells through the activation of Wnt/beta-catenin signaling. Inhibition of MAC30 leads to decreased tumor growth and invasiveness, suggesting it as a potential anticancer target in HCC.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2021)

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Review Biochemistry & Molecular Biology

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc

Sarah K. Madden et al.

Summary: Direct inhibition of c-Myc, a transcription factor overexpressed in many human cancers, has shown promising results in triggering tumor regression with reversible side effects. Challenges and lessons from current inhibitors are evaluated to explore future strategies for translating c-Myc inhibitors into clinical practice, such as miniaturisation of Omomyc and targeting E-box binding.

MOLECULAR CANCER (2021)

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Review Pharmacology & Pharmacy

Baicalin mediated regulation of key signaling pathways in cancer

Shilpi Singh et al.

Summary: Baicalin has shown significant anti-proliferative potential in various cancer cell lines, attracting interest as a potential chemotherapeutic modality. However, its clinical use is limited by low bioavailability, fast metabolism, and other factors. Improving pharmacokinetics and pharmacodynamics, as well as addressing knowledge and technology gaps, are essential for establishing baicalin as an effective and safe compound for cancer treatment.

PHARMACOLOGICAL RESEARCH (2021)

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Article Medicine, Research & Experimental

LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer

Wei Wang et al.

Summary: LINC00491 is highly expressed in liver cancer patients and is associated with poor prognosis. It promotes liver cancer progression by acting as a sponge for miR-324-5p/ROCK1, suggesting it may be a potential therapeutic target for liver cancer.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Chemistry, Medicinal

Synergistic effect of combined treatment with baicalin and emodin on DSS-induced colitis in mouse

Bo Xu et al.

Summary: Combining baicalin and emodin in the treatment of colitis has been found to have a synergistic effect in alleviating inflammation symptoms in mice, involving the modulation of multiple inflammatory pathway proteins.

PHYTOTHERAPY RESEARCH (2021)

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Article Neurosciences

Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice

Yutaka Koizumi et al.

Summary: ROCK inhibition with Y-27632 has been shown to significantly increase the number of synapses in cochlear synaptopathy, demonstrating promising clinical applications for the treatment of sensorineural hearing loss caused by this major pathology.

MOLECULAR BRAIN (2021)

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Review Immunology