4.7 Article

Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Environmental Sciences

Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine

Li Zhang et al.

Summary: Corilagin exhibits significant anticancer effects in gastric cancer treatment by increasing antioxidants levels, improving cell morphology, and reducing the expression of transcription factors, ultimately inducing apoptosis in gastric cancer cells.

ENVIRONMENTAL TOXICOLOGY (2022)

Article Biochemistry & Molecular Biology

PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer

Shahid Karim et al.

Summary: This study found that thymoquinone inhibits glycolytic metabolism in colorectal cancer cells by modulating the PI3/AKT axis and inhibiting the glycolytic enzyme HK2. Overexpression of HK2 is essential for fueling glycolytic metabolism and sustaining tumorigenicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Plant Sciences

Paeonol inhibits the malignancy of Apatinib-resistant gastric cancer cells via LINC00665/miR-665/MAPK1 axis

Ming Li et al.

Summary: This study found that paeonol can inhibit the malignant behaviors of Apatinib-resistant gastric cancer cells by regulating the LINC00665/miR-665/MAPK1 axis. This study suggests for the first time that paeonol may be a potential drug to reverse Apatinib resistance in gastric cancer cells.

PHYTOMEDICINE (2022)

Article Oncology

Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2-mediated autophagy

Lang Fang et al.

Summary: This study reveals the crucial role of circCPM in regulating gastric cancer autophagy and 5-FU resistance by targeting PRKAA2. High expression of circCPM is positively associated with poor survival, and silencing circCPM significantly improves chemosensitivity.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

Nigrosporins B, a Potential Anti-Cervical Cancer Agent, Induces Apoptosis and Protective Autophagy in Human Cervical Cancer Ca Ski Cells Mediated by PI3K/AKT/mTOR Signaling Pathway

Jing Zhang et al.

Summary: This study characterizes the anti-cancer potential of Nigrosporins B, a derivative from marine fungus, in human cervical cancer cells. It was found that Nigrosporins B inhibited cell proliferation, induced apoptosis and autophagy, and suppressed the PI3K/AKT/mTOR signaling pathway. This suggests that Nigrosporins B may be a promising alternative therapeutic agent for cervical cancer.

MOLECULES (2022)

Article Plant Sciences

Combinatorial effect of thymoquinone with chemo agents for tumor therapy

Shah Jehan et al.

Summary: This study highlights the potential of Thymoquinone (TQ) as an adjuvant therapy in cancer treatment. TQ has been shown to enhance the anticancer effects of various chemotherapeutics while reducing their toxicity to vital organs. Further evaluation at preclinical and clinical trial levels is recommended to explore its potential as a novel combinatorial therapy for cancer with minimal adverse effects.

PHYTOMEDICINE (2022)

Review Chemistry, Medicinal

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Milad Iranshahy et al.

Summary: This study investigates the potential of Persian Medicine-recommended foods in preventing and treating CNS-related tremors, specifically Parkinson's disease. The findings suggest that certain plants and substances, such as garlic, cabbage, chickpea seed, cinnamon, saffron, black cumin, black pepper, pistachio, and resveratrol, possess beneficial properties in alleviating and preventing the progression of Parkinson's disease through their antioxidant and anti-inflammatory effects.

PHYTOTHERAPY RESEARCH (2022)

Review Pharmacology & Pharmacy

Aconiti Lateralis Radix Praeparata as Potential Anticancer Herb: Bioactive Compounds and Molecular Mechanisms

Wen Zhang et al.

Summary: Aconiti Lateralis Radix Praeparata (Fuzi) is a traditional herbal medicine widely used in China and other Asian countries, with considerable anticancer, anti-inflammatory, and analgesic effects. Its main components, alkaloids and polysaccharides, have been shown to induce apoptosis and autophagy, inhibit proliferation, migration and invasion, regulate immune function, and affect energy metabolism, making them attractive candidates for anticancer drug development.

FRONTIERS IN PHARMACOLOGY (2022)

Article Oncology

Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways

He Pang et al.

Summary: Baicalin exhibits antitumor effects on osteosarcoma cells by reducing proliferation and invasive potential, inducing apoptosis and autophagy, and inhibiting signaling pathways.

JOURNAL OF BONE ONCOLOGY (2022)

Review Biochemistry & Molecular Biology

Targeting Inflammatory Mediators: An Anticancer Mechanism of Thymoquinone Action

Zakia Akter et al.

Summary: Thymoquinone exhibits anti-inflammatory and immunomodulatory activities in cancer cells, targeting and modulating inflammatory molecules to play a significant role in anticancer activities beyond its chemopreventive role. Further attention is needed to study its role in immunotherapeutics and its development as a future anticancer drug.

CURRENT MEDICINAL CHEMISTRY (2021)

Article Oncology

Thymoquinone Inhibits Proliferation and Migration of MDA-MB-231 Triple Negative Breast Cancer Cells by Suppressing Autophagy, Beclin-1 and LC3

Tuba D. Unal et al.

Summary: The study demonstrates that Thymoquinone (TQ) inhibits cell proliferation, migration, and autophagic activity in triple negative breast cancer cells, as well as suppresses the expression of Beclin-1 and LC3. Additionally, TQ treatment leads to the inhibition of Integrin-beta 1, VEGF, MMP-2, and MMP-9 in TNBC cells.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

Article Food Science & Technology

Thymoquinone induces oxidative stress-mediated apoptosis through downregulation of Jak2/STAT3 signaling pathway in human melanoma cells

Pawan Kumar Raut et al.

Summary: Melanoma is a highly aggressive and treatment-resistant cancer, and a new study found that TQ can induce apoptosis in melanoma cells by hindering the Jak2/STAT3 signaling pathway through ROS generation.

FOOD AND CHEMICAL TOXICOLOGY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Pharmacology & Pharmacy

Nigella Plants - Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies

Bahare Salehi et al.

Summary: The Nigella genus, especially Nigella sativa, is well-known for its culinary and medicinal properties in regions like Eastern Europe and the Middle East. The seeds of Nigella plants contain beneficial omega-6 fatty acids and phytochemicals like thymoquinone, making them a potential source of functional ingredients. Further research, including clinical trials, is needed to standardize the use of Nigella for health benefits and culinary applications.

FRONTIERS IN PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells

Xuejian Zhou et al.

Summary: This study confirms the multifaceted effects of thymoquinone (TQ) on bladder carcinoma cells, including inhibition of autophagy and activation of microRNA pathways in suppressing survival, proliferation, migration, and invasion.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Review Gastroenterology & Hepatology

Gastric Cancer: Where Are We Heading?

Pawel Petryszyn et al.

DIGESTIVE DISEASES (2020)

Review Medicine, Research & Experimental

Recent Advances in the Surgical Treatment of Advanced Gastric Cancer: A Review

Zhaoyang Tan

MEDICAL SCIENCE MONITOR (2019)

Review Oncology

Updates on Management of Gastric Cancer

Fabian M. Johnston et al.

CURRENT ONCOLOGY REPORTS (2019)

Review Biochemistry & Molecular Biology

Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine et al.

Review Medicine, Research & Experimental

Thymoquinone: A novel strategy to combat cancer: A review

Muhammad Imran et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Oncology

Targeting Autophagy in Cancer

Angelique V. Onorati et al.

CANCER (2018)

Review Biochemistry & Molecular Biology

Thymoquinone Shows the Diverse Therapeutic Actions by Modulating Multiple Cell Signaling Pathways: Single Drug for Multiple Targets

Masood A. Khan et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2018)

Review Oncology

Progress in the treatment of advanced gastric cancer

Zheyu Song et al.

TUMOR BIOLOGY (2017)

Article Gastroenterology & Hepatology

Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation

Hsi-Hsien Hsu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Review Food Science & Technology

Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa

Amin F. Majdalawieh et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

Article Gastroenterology & Hepatology

Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro

Wen-Qian Zhu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Review Plant Sciences

Naturally derived anti-inflammatory compounds from Chinese medicinal plants

Qiuhong Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2013)