期刊
PHYTOTHERAPY RESEARCH
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1002/ptr.7813
关键词
depression; fecal microbiota transplantation; gut barrier; microbiota-gut-brain axis; Polygonum sibiricum polysaccharides
The study found that Polygonum sibiricum polysaccharides (PSP) exerted antidepressant-like effects via the microbiota-gut-brain (MGB) axis. Transplantation of fecal microbiota (FMT) from PSP administration mice significantly reversed depressive-like behaviors in CUMS-induced mice and influenced neurotransmitter levels and inflammation.
Polygonum sibiricum polysaccharides (PSP) are one of the main active components of Polygonatum sibiricum, which is a traditional Chinese medicine with food and drug homologies. Recent studies have revealed the antidepressant-like effects of PSP. However, the precise mechanisms have not been clarified. Therefore, the present study was conducted to explore that whether PSP could exert the antidepressant-like effects via microbiota-gut-brain (MGB) axis in chronic unpredictable mild stress (CUMS)-induced depressive mice by transplantation of fecal microbiota (FMT) from PSP administration mice. FMT markedly reversed the depressive-like behaviors of CUMS-induced mice in the open field, the sucrose preference, the tail suspension, the forced swimming, and the novelty-suppressed feeding tests. FMT significantly increased the levels of 5-hydroxytryptamine and norepinephrine, decreased the levels of the pro-inflammatory cytokines in the hippocampus and reduced the levels of corticosterone, an adrenocorticotropic-hormone, in the serum of CUMS-induced mice. In addition, administration of PSP and FMT significantly increased the expressions of ZO-1 and occludin in the colon and decreased the levels of lipopolysaccharide and interferon-gamma in the serum of CUMS-induced mice. Moreover, administration of PSP and FMT regulated the signaling pathways of PI3K/AKT/TLR4/NF-kappa B and ERK/CREB/BDNF. Taken together, these findings indicated that PSP exerted antidepressant-like effects via the MGB axis.
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