期刊
JOURNAL OF VETERINARY MEDICAL SCIENCE
卷 78, 期 6, 页码 1051-1054出版社
JAPAN SOC VET SCI
DOI: 10.1292/jvms.15-0711
关键词
canine rheumatoid arthritis; cranial cruciate ligament rupture; dog; idiopathic polyarthritis; matrix metalloproteinase
资金
- Grants-in-Aid for Scientific Research [15H04590, 15KK0275, 16K15045] Funding Source: KAKEN
The activity of matrix metalloproteinase (MMP)-2 and MMP-9 in synovial fluids (SF) sampled from dogs with joint disorders was investigated by gelatin zymography and densitometry. Pro-MMP-2 showed similar activity levels in dogs with idiopathic polyarthritis (IPA; n=17) or canine rheumatoid arthritis (cRA; n=4), and healthy controls (n=10). However, dogs with cranial cruciate ligament rupture (CCLR; n=5) presented significantly higher pro-MMP-2 activity than IPA and healthy dogs. Meanwhile, dogs with IPA exhibited significantly higher activity of pro- and active MMP-9 than other groups. Activity levels in pro- and active MMP-9 in cRA and CCLR dogs were not significantly different from those in healthy controls. Different patterns of MMP-2 and MMP-9 activity may reflect the differences in the underlying pathological processes.
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