A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment

Article Integrative & Complementary Medicine

Dopamine relieves inflammatory responses through the D2 receptor after electroacupuncture at ST36 in a mouse model of chronic obstructive pulmonary disease

Xuemei Liu et al.

Summary: Electroacupuncture (EA) at ST36 can alleviate inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) through the dopamine D2 receptor pathway.

ACUPUNCTURE IN MEDICINE (2023)

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Article Medicine, Research & Experimental

Study on the mechanism of Yupingfeng powder in the treatment of immunosuppression based on UPLC.QTOF.MS, network pharmacology and molecular biology verification

Yuhua Li et al.

Summary: This study investigated the effect of Yupingfeng powder on immunosuppression, identifying 98 monomer compounds and 47 effective components. The powder was found to reduce Candida albicans infection in mice, alleviate inflammation, and improve immune response pathways such as IL-17 signaling.

LIFE SCIENCES (2022)

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Article Chemistry, Medicinal

Identifying absorbable bioactive constituents of Yupingfeng Powder acting on COVID-19 through integration of UPLC-Q/TOF-MS and network pharmacology analysis

Linyan Wang et al.

Summary: This study aimed to determine the active constituents of Yupingfeng Powder (YPF) and elucidate its potential mechanisms for the treatment of coronavirus disease 2019 (COVID-19). UPLC-Q/TOF-MS and LC-QQQ-MS were used to identify the components and absorbable constituents of YPF. Network pharmacology was employed to search for the targets of YPF's absorbable bioactive constituents and identify the key targets of COVID-19. The study found important constituents and targets for the treatment of COVID-19, as well as the metabolic reactions and functional pathways involved.

CHINESE HERBAL MEDICINES (2022)

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Review Chemistry, Medicinal

Network Pharmacology Approach for Medicinal Plants: Review and Assessment

Fatima Noor et al.

Summary: The use of natural products, specifically medicinal plants, in medicine has proven to be crucial due to their ability to interact with cellular targets involved in diseases. Network pharmacology has emerged as a systematic paradigm in drug discovery, providing a comprehensive understanding of the bioactive components found in medicinal plants.

PHARMACEUTICALS (2022)

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Article Integrative & Complementary Medicine

Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases

Minye Qu et al.

Summary: By utilizing network pharmacology and molecular docking technology, this study explored the potential mechanisms of Yupingfeng Powder (YPFP) in the treatment of allergic diseases. The active ingredients and targets of YPFP were identified, and the biological processes and signaling pathways involved in allergy treatment were elucidated. The findings provide a theoretical basis for subsequent allergy treatment and drug development.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Review Pediatrics

Adjuvant treatment with yupingfeng granules for recurrent respiratory tract infections in children: A systematic review and meta-analysis

Lu Zhang et al.

Summary: This study demonstrated that adjuvant YPFG therapy can improve clinical response rate and increase serum immunoglobulin levels while decreasing TNF-alpha level in children with recurrent respiratory tract infections.

FRONTIERS IN PEDIATRICS (2022)

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Article Mathematical & Computational Biology

Molecular Mechanism of YuPingFeng in the Treatment of Asthma Based on Network Pharmacology and Molecular Docking Technology

Li Shen et al.

Summary: Using network pharmacology and molecular docking, this study explored the molecular targets and mechanism of the traditional Chinese medicine YuPingFeng (YPF) for the treatment of asthma. The results showed that YPF can alleviate asthma symptoms through multiple pathways and targets, and has good affinity with core genes related to asthma.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2022)

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Article Pediatrics

Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection: A randomized clinical trial

Baoping Xu et al.

Summary: This study evaluated the safety and efficacy of YPF granules in treating children with RRTI. The results showed that YPF granules were noninferior to the active control drug pidotimod and superior to placebo in treating RRTI in children, with a high safety profile.

PEDIATRIC INVESTIGATION (2022)

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Article Allergy

Real-world evidence Patient views on asthma in respiratory specialist clinics in America

John Oppenheimer et al.

Summary: In specialty respiratory clinics in the United States, approximately half of asthma patients have inadequately controlled disease, leading to more respiratory illnesses, comorbidities, poorer quality of life, increased exacerbations, and higher healthcare resource utilization.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2021)

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Article Chemistry, Analytical

Integrated metabolomics and network pharmacology approach to reveal immunomodulatory mechanisms of Yupingfeng granules

Moying Li et al.

Summary: Systems biology is a method that combines Chinese herbal formula regulation with molecular-level analysis, and in this study, the immunomodulatory mechanisms of YPFG were investigated using metabolomics and network pharmacology methods. The study showed that YPFG's immunomodulatory effects may be related to lipid metabolism and bile acid metabolism, and flavonoid and saponin were identified as major active ingredients. These components may regulate abnormal bile acid metabolism by enhancing the expression of FXR and LXR alpha, providing a scientific basis for precise clinical medication.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

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Article Cell Biology

PI3K/AKT/mTOR and TLR4/MyD88/NF-κB Signaling Inhibitors Attenuate Pathological Mechanisms of Allergic Asthma

Baowei Ma et al.

Summary: This study demonstrates that targeting the imbalance of Th1/Th2 and Th17/Treg with signaling molecules like mTOR, PI3K, Akt, and MyD88 can control asthma attacks. Treatment of asthma patients with compounds such as ketamine, metformin, triciribine, LY294002, and torin2 can significantly reduce inflammation and symptoms.

INFLAMMATION (2021)

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Review Allergy

Pharmacological Rationale for Targeting IL-17 in Asthma

Siti Farah Rahmawati et al.

Summary: IL-17 plays a significant role in asthma and its interaction with the Th2 pathway provides a rationale for therapeutic targeting of the IL-17 pathway. Experimental models suggest that targeting the IL-17 pathway may be beneficial in asthma. Moreover, increased activation of the Th17/IL-17 axis is correlated with reduced inhaled corticosteroids sensitivity, suggesting that targeting the IL-17 pathway might reverse ICS unresponsiveness.

FRONTIERS IN ALLERGY (2021)

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Article Pharmacology & Pharmacy

A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence

Kaifan Bao et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Mechanism of YuPingFeng in the Treatment of COPD Based on Network Pharmacology

Yunhong Yin et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

Potential therapeutic and pharmacological effects of Wogonin: an updated review

Do Luong Huynh et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Biochemistry & Molecular Biology

Quercetin Inhibits the Production of IL-1β-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-κB Signaling Pathways

Shu-Chen Cheng et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Defining Bronchial Asthma with Phosphoinositide 3-Kinase Delta Activation: Towards Endotype-Driven Management

Jae Seok Jeong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

TNF activity and T cells

Amit K. Mehta et al.

CYTOKINE (2018)

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Review Medicine, General & Internal

Asthma

Alberto Papi et al.

LANCET (2018)

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Article Cardiac & Cardiovascular Systems

Chinese herbal medicine formula for acute asthma: A multi-center, randomized, double-blind, proof-of-concept trial

Hong Ping Zhang et al.

RESPIRATORY MEDICINE (2018)

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Review Allergy

Inhaled Corticosteroids Safety and Adverse Effects in Patients with Asthma

Enrico Heffler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2018)

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Article Chemistry, Medicinal

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

Anroop Nair et al.

DRUG DEVELOPMENT RESEARCH (2018)

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Article Pharmacology & Pharmacy

Yupingfeng San Inhibits NLRP3 Inflammasome to Attenuate the Inflammatory Response in Asthma Mice

Xue Liu et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Review Biochemistry & Molecular Biology

Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches

Edwin J. Yoo et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

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Article Anatomy & Morphology

Baicalein, wogonin, and Scutellaria baicalensis ethanol extract alleviate ovalbumin-induced allergic airway inflammation and mast cell-mediated anaphylactic shock by regulation of Th1/Th2 imbalance and histamine release

Thi Tho Bui et al.

ANATOMY & CELL BIOLOGY (2017)

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Article Critical Care Medicine

Wogonin Induces Eosinophil Apoptosis and Attenuates Allergic Airway Inflammation

Christopher D. Lucas et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Article Nutrition & Dietetics

Wogonin, a plant flavone from Scutellariae radix, attenuated ovalbumin-induced airway inflammation in mouse model of asthma via the suppression of IL-4/STAT6 signaling

Eun Kyung Ryu et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2015)

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Article Medicine, General & Internal

Risk factors for asthma: is prevention possible?

Richard Beasley et al.

LANCET (2015)

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Article Multidisciplinary Sciences

Systems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease

Jiansheng Li et al.

SCIENTIFIC REPORTS (2015)

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Review Respiratory System

Asthma and respiratory physiology: Putting lung function into perspective

Giuseppe Francesco Sferrazza Papa et al.

RESPIROLOGY (2014)

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Review Immunology

Regulation of NF-κB by TNF family cytokines

Matthew S. Hayden et al.

SEMINARS IN IMMUNOLOGY (2014)

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Article Chemistry, Multidisciplinary

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

Jinlong Ru et al.

JOURNAL OF CHEMINFORMATICS (2014)

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Article Pharmacology & Pharmacy

Bradykinin-induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways

Federica Sabatini et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2013)

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Article Integrative & Complementary Medicine

A Network Pharmacology Approach to Evaluating the Efficacy of Chinese Medicine Using Genome-Wide Transcriptional Expression Data

Leihong Wu et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

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Article Biochemistry & Molecular Biology

A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

Xue Xu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

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Article Nutrition & Dietetics

Kaempferol Suppresses Eosionphil Infiltration and Airway Inflammation in Airway Epithelial Cells and in Mice with Allergic Asthma

Ju-Hyun Gong et al.

JOURNAL OF NUTRITION (2012)

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Article Chemistry, Medicinal

GPU Accelerated Chemical Similarity Calculation for Compound Library Comparison

Chao Ma et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)

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Article Pharmacology & Pharmacy

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

Carol Kilkenny et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

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Letter Allergy

T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma

Wisam Al-Ramli et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Pharmacology & Pharmacy

TNF-α in asthma

Mike Berry et al.

CURRENT OPINION IN PHARMACOLOGY (2007)

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Review Allergy

Severe asthma: Lessons from the Severe Asthma Research Program

Sally E. Wenzel et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Article Biochemistry & Molecular Biology

Cyclooxygenase enzymes in allergic inflammation and asthma

MA Carey et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2003)

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Article Critical Care Medicine

Cigarette smoke-induced airway hyperresponsiveness is not dependent on elevated immunoglobulin and eosinophilic inflammation in a mouse model of allergic airway disease

EG Barrett et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)

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A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment

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