Stelleratenoids A-F, macrocyclic daphnane orthoesters with anti-HIV activity from the roots of Stellera chamaejasme L.

Article Chemistry, Medicinal

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

Jelena Popovic-Djordjevic et al.

Summary: This article reviews the latest information on the anti-HIV activity of natural and synthetic compounds, including their history, mechanism of action, and the role of plants and their bioactive compounds as a source of new anti-HIV drugs.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Medicinal

Chamaejasnoids A-E, a 2,3-seco-guaiane sesquiterpenoid with a 5/6/7 bridged ring system and related metabolites from Stellera chamaejasme L.

Maobo Wu et al.

Summary: Sixteen guaiane-type sesquiterpenoids were isolated from Stellera chamaejasme L., including five new compounds. A plausible biosynthetic pathway for one compound was proposed, and it exhibited selective cytotoxicity against HCT8 cell line.

FITOTERAPIA (2022)

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Review Plant Sciences

Ethnopharmacology, phytochemistry, pharmacology, clinical applications and toxicology of the genus Stellera Linn.: A review

Nuan Zhang et al.

Summary: The Stellera genus, which consists of several species of perennial herbs and shrubs mainly found in temperate regions of East Asia to West Asia, has been traditionally used for treating various ailments. The plants contain chemical constituents with potential pharmacological activities, but caution is needed due to their toxic nature. Further research is required to fully understand the medical applications, chemical constituents, pharmacological properties, clinical uses, and toxicology of the Stellera genus.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Guaiane-type sesquiterpenoids from the roots of Stellera chamaejasme L. and their neuroprotective activities

Zhuo-Yang Cheng et al.

Summary: Nine undescribed guaiane-type sesquiterpenoids, known as stelleraterpenoids A-I, were isolated from the roots of Stellera chamaejasme L. along with seven reported congeners. The compounds showed neuroprotective effects on H2O2-induced damage in human neuroblastoma SH-SY5Y cells. Stelleraguaianone B exhibited the best activity in inhibiting cell apoptosis compared to the positive control Trolox.

PHYTOCHEMISTRY (2021)

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Article Immunology

Reflections on 40 Years of AIDS

Kevin M. De Cock et al.

Summary: The 40th anniversary of AIDS marks a milestone in the ongoing battle against the disease, with lessons learned from past epidemics like Ebola and the ongoing COVID-19 pandemic. While progress has been made, challenges remain in ending the AIDS epidemic, especially in the context of emerging health threats and the need for enhanced preparedness.

EMERGING INFECTIOUS DISEASES (2021)

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Article Chemistry, Organic