期刊
PHYSICAL REVIEW LETTERS
卷 130, 期 21, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.130.218401
关键词
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Previous computer simulations have shown that existing models of action potential wave propagation in the heart do not match observed wave propagation behavior. However, we have found that this discrepancy can be resolved by introducing ephaptic coupling as a primary factor in wave front propagation. This not only provides support for the importance of ephaptic coupling in normal wave propagation, but also helps to explain the discordant alternans patterns observed in experiments.
Previous computer simulations have suggested that existing models of action potential wave propagation in the heart are not consistent with observed wave propagation behavior. Specifically, computer models cannot simultaneously reproduce the rapid wave speeds and small spatial scales of discordant alternans patterns measured experimentally in the same simulation. The discrepancy is important, because discordant alternans can be a key precursor to the development of abnormal and dangerous rapid rhythms in the heart. In this Letter, we show that this paradox can be resolved by allowing so-called ephaptic coupling to play a primary role in wave front propagation in place of conventional gap-junction coupling. With this modification, physiological wave speeds and small discordant alternans spatial scales both occur with gap-junction resistance values that are more in line with those observed in experiments. Our theory thus also provides support to the hypothesis that ephaptic coupling plays an important role in normal wave propagation.
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