期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 378, 期 1877, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2022.0055
关键词
adaptation; mutation; prediction; theory; population genetics
类别
Predicting evolutionary outcomes is crucial, and current focus is on adaptive processes mainly through selection. However, adaptive processes rely on new mutations, which are influenced by predictable biases. This article provides an overview of existing theory and evidence for mutation-biased adaptation, discussing its implications for prediction in various fields. The authors argue that with improving knowledge on mutational biases, short-term prediction challenges can be addressed effectively.
Predicting evolutionary outcomes is an important research goal in a diversity of contexts. The focus of evolutionary forecasting is usually on adaptive processes, and efforts to improve prediction typically focus on selection. However, adaptive processes often rely on new mutations, which can be strongly influenced by predictable biases in mutation. Here, we provide an overview of existing theory and evidence for such mutation-biased adaptation and consider the implications of these results for the problem of prediction, in regard to topics such as the evolution of infectious diseases, resistance to biochemical agents, as well as cancer and other kinds of somatic evolution. We argue that empirical knowledge of mutational biases is likely to improve in the near future, and that this knowledge is readily applicable to the challenges of short-term prediction.This article is part of the theme issue 'Interdisciplinary approaches to predicting evolutionary biology'.
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